PMID- 29257902
OWN - NLM
STAT- MEDLINE
DCOM- 20180816
LR  - 20180816
IS  - 1532-4311 (Electronic)
IS  - 0882-0139 (Linking)
VI  - 47
IP  - 2
DP  - 2018 Feb
TI  - Association between the polymorphism of HLA and ESRD in Dalian Han population 
      located in north of China.
PG  - 212-219
LID - 10.1080/08820139.2017.1416397 [doi]
AB  - BACKGROUND: End-stage renal disease (ESRD), the last stage of chronic renal 
      failure, is a global health problem. The number of ESRD patients worldwide is 
      increasing faster than the number of kidneys available per year for renal 
      transplantation. Most of the ESRD patients are awaiting renal transplantation. 
      The immune response to the transplanted kidney is directed mainly against 
      mismatched human leukocyte antigen (HLA) glycoproteins expressed on donor 
      tissues. Thus, the analysis of HLA allele and haplotype polymorphisms is valuable 
      not only for identifying ESRD susceptibility factors but also to improve graft 
      survival. METHODS: In this study, 163 Han ESRD patients were recruited to 
      participate. The blood samples were genotyped by sequence-specific 
      oligonucleotide method. A group of 14,529 healthy Chinese Han individuals 
      registered at the Dalian Blood Center as bone marrow donors, living in the same 
      region and of the same ethnicity, were used as controls. RESULTS: We found that 
      only one allele, HLA-DRB1*12, showed a positive association with ESRD (p = 0.004, 
      p(c) = 0.028, odds ratio = 1.530, 95% confidence interval = 1.147-2.041); 
      A*02-B*40-DRB1*09, A*02-B*40-DRB1*12, A*24-B*15-DRB1*12, and B*40-DRB1*12 were 
      significantly more frequent in ESRD patients after Bonferroni correction 
      (p(c) < 0.05). CONCLUSION: They were potentially valuable predictors for 
      evaluating the risk of ESRD in the Dalian Han population.
FAU - Shao, Lin-Nan
AU  - Shao LN
AD  - a Blood Group Research Department, Dalian Blood Center , Dalian , Liaoning , 
      China.
FAU - Yang, Yang
AU  - Yang Y
AD  - b The Third Department of Urology (Renal Transplant) , Dalian Friendship Hospital 
      , Dalian , Liaoning , China.
FAU - Zhang, Shu-Ting
AU  - Zhang ST
AD  - a Blood Group Research Department, Dalian Blood Center , Dalian , Liaoning , 
      China.
FAU - Zhou, Shi-Hang
AU  - Zhou SH
AD  - a Blood Group Research Department, Dalian Blood Center , Dalian , Liaoning , 
      China.
FAU - Duan, Ying
AU  - Duan Y
AD  - a Blood Group Research Department, Dalian Blood Center , Dalian , Liaoning , 
      China.
FAU - Meng, Qing-Li
AU  - Meng QL
AD  - a Blood Group Research Department, Dalian Blood Center , Dalian , Liaoning , 
      China.
FAU - Liang, Xiao-Hua
AU  - Liang XH
AD  - a Blood Group Research Department, Dalian Blood Center , Dalian , Liaoning , 
      China.
FAU - Yu, Wei-Jian
AU  - Yu WJ
AD  - a Blood Group Research Department, Dalian Blood Center , Dalian , Liaoning , 
      China.
LA  - eng
PT  - Journal Article
DEP - 20171219
PL  - England
TA  - Immunol Invest
JT  - Immunological investigations
JID - 8504629
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*12:01:01 antigen)
SB  - IM
MH  - Adult
MH  - China
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - *Genotype
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Humans
MH  - Kidney Failure, Chronic/*genetics
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Population Groups
MH  - Risk
MH  - Young Adult
OTO - NOTNLM
OT  - Human leukocyte antigens
OT  - end-stage renal disease
OT  - polymorphism
OT  - susceptibility
EDAT- 2017/12/20 06:00
MHDA- 2018/08/17 06:00
CRDT- 2017/12/20 06:00
PHST- 2017/12/20 06:00 [pubmed]
PHST- 2018/08/17 06:00 [medline]
PHST- 2017/12/20 06:00 [entrez]
AID - 10.1080/08820139.2017.1416397 [doi]
PST - ppublish
SO  - Immunol Invest. 2018 Feb;47(2):212-219. doi: 10.1080/08820139.2017.1416397. Epub 
      2017 Dec 19.