PMID- 29258393
OWN - NLM
STAT- MEDLINE
DCOM- 20180905
LR  - 20200225
IS  - 1938-2723 (Electronic)
IS  - 1076-0296 (Print)
IS  - 1076-0296 (Linking)
VI  - 24
IP  - 4
DP  - 2018 May
TI  - Postoperative Changes in the Systemic Inflammatory Milieu in Older Surgical 
      Patients.
PG  - 583-588
LID - 10.1177/1076029617747412 [doi]
AB  - Dysregulated inflammation is a central component of wound healing following 
      surgery. We prospectively enrolled older patients (n = 25, age 65 +/- 7 years) 
      undergoing elective total knee arthroplasty or total hip arthroplasty secondary 
      to advanced osteoarthritis (OA) and healthy controls (n = 48). Inflammatory, 
      proangiogenic (vascular endothelial growth factor [VEGF], monocyte 
      chemoattractant protein-1 [MCP-1], and interleukin-8 [IL-8]), and antiangiogenic 
      (interferon gamma [IFN-gamma] and IL-4) factors were measured using a high-sensitivity 
      biochip. Patients with OA had significantly higher baseline VEGF (10.5 +/- 1.2 
      pg/mL vs 4.8 +/- 0.2 pg/mL, P < .001), MCP-1 (130.6 +/- 7.7 pg/mL vs 88.6 +/- 3.9 
      pg/mL, P < .0001), and IL-8 (4.0 +/- 0.5 pg/mL vs 2.6 +/- 0.1 pg/mL, P < .05). 
      Postoperatively, the levels of VEGF (10.5 +/- 1.2 pg/mL vs 18.8 +/- 1.5 pg/mL, P < 
      .001) and MCP-1 (130.6 +/- 7.7 pg/mL vs 153.1 +/- 11.5 pg/mL, P < .05) increased 
      significantly. Baseline and postoperative MCP-1 levels correlated positively and 
      significantly with age. The levels of IFN-gamma and IL-4 (which has anti-inflammatory 
      properties) did not significantly differ at baseline in patients with OA compared 
      to controls and did not significantly rise postoperatively. We conclude that 
      systemic levels of pro-inflammatory and angiogenic proteins are increased in 
      patients with OA and rise further postoperatively, while proteins that restrain 
      inflammation and angiogenesis do not coordinately rise. These findings implicate 
      imbalance in inflammatory pathways in OA that may contribute to its pathobiology.
FAU - Shih, Lauren
AU  - Shih L
AD  - 1 Molecular Medicine Program, University of Utah, Salt Lake City, UT, USA.
AD  - 2 Department of Internal Medicine, University of Washington, Seattle, WA, USA.
FAU - Guler, Nil
AU  - Guler N
AD  - 3 Department of Pathology, Loyola University Medical Center, Maywood, IL, USA.
FAU - Syed, Daneyal
AU  - Syed D
AD  - 3 Department of Pathology, Loyola University Medical Center, Maywood, IL, USA.
FAU - Hopkinson, William
AU  - Hopkinson W
AD  - 3 Department of Pathology, Loyola University Medical Center, Maywood, IL, USA.
FAU - McComas, Kyra N
AU  - McComas KN
AD  - 1 Molecular Medicine Program, University of Utah, Salt Lake City, UT, USA.
FAU - Walborn, Amanda
AU  - Walborn A
AD  - 3 Department of Pathology, Loyola University Medical Center, Maywood, IL, USA.
FAU - Hoppensteadt, Debra
AU  - Hoppensteadt D
AD  - 3 Department of Pathology, Loyola University Medical Center, Maywood, IL, USA.
FAU - Fareed, Jawed
AU  - Fareed J
AD  - 3 Department of Pathology, Loyola University Medical Center, Maywood, IL, USA.
FAU - Rondina, Matthew T
AU  - Rondina MT
AD  - 1 Molecular Medicine Program, University of Utah, Salt Lake City, UT, USA.
AD  - 4 Department of Pathology, George E. Wahlen VAMC Geriatric Research, Education 
      and Clinical Center, Salt Lake City, UT, USA.
AD  - 5 Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA.
LA  - eng
GR  - U54 HL112311/HL/NHLBI NIH HHS/United States
GR  - R01 AG048022/AG/NIA NIH HHS/United States
GR  - UL1 TR001067/TR/NCATS NIH HHS/United States
GR  - R01 HL130541/HL/NHLBI NIH HHS/United States
GR  - R01 HL126547/HL/NHLBI NIH HHS/United States
PT  - Journal Article
DEP - 20171219
PL  - United States
TA  - Clin Appl Thromb Hemost
JT  - Clinical and applied thrombosis/hemostasis : official journal of the 
      International Academy of Clinical and Applied Thrombosis/Hemostasis
JID - 9508125
RN  - 0 (Angiogenesis Inhibitors)
SB  - IM
MH  - Aged
MH  - Angiogenesis Inhibitors/pharmacology/*therapeutic use
MH  - Female
MH  - Humans
MH  - Inflammation/*etiology/pathology
MH  - Male
MH  - Osteoarthritis/*etiology/pathology
MH  - Postoperative Period
PMC - PMC6714708
OTO - NOTNLM
OT  - aging
OT  - angiogenesis
OT  - inflammation
OT  - obesity
OT  - surgery
COIS- Declaration of Conflicting Interests: The author(s) declared no potential 
      conflict of interest with respect to the research, authorship, and/or publication 
      of this article.
EDAT- 2017/12/21 06:00
MHDA- 2018/09/06 06:00
PMCR- 2017/12/19
CRDT- 2017/12/21 06:00
PHST- 2017/12/21 06:00 [pubmed]
PHST- 2018/09/06 06:00 [medline]
PHST- 2017/12/21 06:00 [entrez]
PHST- 2017/12/19 00:00 [pmc-release]
AID - 10.1177_1076029617747412 [pii]
AID - 10.1177/1076029617747412 [doi]
PST - ppublish
SO  - Clin Appl Thromb Hemost. 2018 May;24(4):583-588. doi: 10.1177/1076029617747412. 
      Epub 2017 Dec 19.