PMID- 29258531
OWN - NLM
STAT- MEDLINE
DCOM- 20180730
LR  - 20181113
IS  - 1746-1596 (Electronic)
IS  - 1746-1596 (Linking)
VI  - 12
IP  - 1
DP  - 2017 Dec 19
TI  - Malignant rhabdoid tumor in the renal allograft of an adult transplant recipient: 
      a unique case of a rare tumor.
PG  - 86
LID - 10.1186/s13000-017-0677-5 [doi]
LID - 86
AB  - BACKGROUND: Renal transplant recipients have increased risk for developing 
      malignant diseases because of immunosuppression or donor-to-recipient 
      transmission. Malignant rhabdoid tumor (MRT) is a rare, highly aggressive and 
      lethal tumor primarily affecting the kidney of infants and young children. MRT 
      has not been reported in the renal allograft of an adult recipient after kidney 
      transplantation. CASE PRESENTATION: In this report, a 47-year-old woman who 
      received a kidney transplantation from an infant donor and developed a mass in 
      the transplanted kidney is presented. Pathological examinations revealed a 
      malignant tumor with rhabdoid cells morphologically and the loss of INI1 
      expression immunohistochemically. The diagnosis of malignant rhabdoid tumor in 
      the transplanted kidney was made. We confirmed that donor-to-recipient malignancy 
      transmission was the cause of MRT in the transplanted kidney by fluorescence in 
      situ hybridization (FISH) and short tandem repeat (STR) analysis. CONCLUSION: To 
      our knowledge, this is the first case of MRT in an adult renal allograft 
      recipient. This report highlights the importance of the criteria for selection of 
      donors to screen possible malignant tumors transmission.
FAU - Xiong, Jing
AU  - Xiong J
AD  - Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030, 
      People's Republic of China.
FAU - Su, Tiefen
AU  - Su T
AD  - Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030, 
      People's Republic of China.
AD  - Department of Pathology, School of Basic Medical Science, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, 430030, People's Republic 
      of China.
FAU - Zhu, Pengcheng
AU  - Zhu P
AD  - Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030, 
      People's Republic of China. zhupengcheng@hust.edu.cn.
AD  - Department of Pathology, School of Basic Medical Science, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, 430030, People's Republic 
      of China. zhupengcheng@hust.edu.cn.
FAU - Ao, Qilin
AU  - Ao Q
AD  - Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030, 
      People's Republic of China.
AD  - Department of Pathology, School of Basic Medical Science, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, 430030, People's Republic 
      of China.
FAU - Ruan, Qiurong
AU  - Ruan Q
AD  - Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030, 
      People's Republic of China.
AD  - Department of Pathology, School of Basic Medical Science, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, 430030, People's Republic 
      of China.
FAU - Wang, Guoping
AU  - Wang G
AD  - Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030, 
      People's Republic of China.
AD  - Department of Pathology, School of Basic Medical Science, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, 430030, People's Republic 
      of China.
LA  - eng
GR  - 81502296/National Natural Science Foundation of China/
PT  - Case Reports
PT  - Journal Article
DEP - 20171219
PL  - England
TA  - Diagn Pathol
JT  - Diagnostic pathology
JID - 101251558
SB  - IM
MH  - Allografts/*pathology
MH  - Female
MH  - Humans
MH  - Kidney Neoplasms/*pathology
MH  - *Kidney Transplantation
MH  - Middle Aged
MH  - Rhabdoid Tumor/*pathology
MH  - Transplant Recipients
PMC - PMC5738181
OTO - NOTNLM
OT  - Donor-to-recipient malignancy transmission
OT  - Kidney transplantation
OT  - Malignant rhabdoid tumor (MRT)
OT  - SMARCB1/INI1
COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: This study was approved by the Ethics 
      committee of Tongji Hospital, Tongji Medical College, Huazhong University of 
      Science and Technology. CONSENT FOR PUBLICATION: Written informed consent for 
      publication of the clinical details and/or clinical images was obtained from a 
      relative of the patient. A copy of the consent form is available for review by 
      the Editor of this journal. COMPETING INTERESTS: The authors declare that they 
      have no competing interests. PUBLISHER'S NOTE: Springer Nature remains neutral 
      with regard to jurisdictional claims in published maps and institutional 
      affiliations.
EDAT- 2017/12/21 06:00
MHDA- 2018/07/31 06:00
PMCR- 2017/12/19
CRDT- 2017/12/21 06:00
PHST- 2017/06/27 00:00 [received]
PHST- 2017/12/08 00:00 [accepted]
PHST- 2017/12/21 06:00 [entrez]
PHST- 2017/12/21 06:00 [pubmed]
PHST- 2018/07/31 06:00 [medline]
PHST- 2017/12/19 00:00 [pmc-release]
AID - 10.1186/s13000-017-0677-5 [pii]
AID - 677 [pii]
AID - 10.1186/s13000-017-0677-5 [doi]
PST - epublish
SO  - Diagn Pathol. 2017 Dec 19;12(1):86. doi: 10.1186/s13000-017-0677-5.