PMID- 29258854
OWN - NLM
STAT- MEDLINE
DCOM- 20180813
LR  - 20201209
IS  - 1872-7573 (Electronic)
IS  - 0378-8741 (Linking)
VI  - 214
DP  - 2018 Mar 25
TI  - Ameliorative effects of Juniperus rigida fruit on oxazolone- and 
      2,4-dinitrochlorobenzene-induced atopic dermatitis in mice.
PG  - 160-167
LID - S0378-8741(17)31995-5 [pii]
LID - 10.1016/j.jep.2017.12.022 [doi]
AB  - ETHNOPHARMACOLOGICAL RELEVANCE: The fruits of Juniperus rigida have been used in 
      Korean traditional medicine for the treatment of inflammatory diseases in humans 
      such as rheumatoid arthritis. AIM OF THE STUDY: This study aimed to investigate 
      the anti-atopic properties of J. rigida fruit in in vivo murine atopic dermatitis 
      (AD) models. METHODS AND RESULTS: BALB/c mouse ears ad SKH-1 hairless mice 
      stimulated with oxazolone (4 weeks) and DNCB (3 weeks), respectively, were 
      treated with the 1% Juniperus rigida fruit EtOH extract (JFE). The JFE improved 
      AD symptoms in both oxazolone- and DNCB-induced AD mice by accelerating skin 
      barrier recovery function and suppressing the overproduction of serum 
      immunoglobulin E (IgE) and interleukin 4 (IL-4). The JFE was found to contain 
      isoscutellarein-7-O-beta-xylopyranoside, cupressuflavone, podocarpusflavone A, and 
      hinokiflavone as major components based on phytochemical analysis. Eight 
      flavonoids were isolated from JFE, and of those, cupressuflavone and 
      isoscutellarein-7-O-beta-xylopyranoside strongly down-regulated IL-4 expression and 
      beta-hexosaminidase release in RBL-2H3 cells. CONCLUSION: Therapeutic attempts with 
      J. rigida fruit and its active components might be useful in treating AD and 
      related skin inflammatory diseases.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Lee, Sullim
AU  - Lee S
AD  - Natural Products Research Institute, Korea Institute of Science and Technology, 
      Gangneung 25451, Republic of Korea. Electronic address: sullimlee@kist.re.kr.
FAU - Park, No-June
AU  - Park NJ
AD  - Natural Products Research Institute, Korea Institute of Science and Technology, 
      Gangneung 25451, Republic of Korea. Electronic address: 115519@kist.re.kr.
FAU - Bong, Sim-Kyu
AU  - Bong SK
AD  - Natural Products Research Institute, Korea Institute of Science and Technology, 
      Gangneung 25451, Republic of Korea. Electronic address: 115044@kist.re.kr.
FAU - Jegal, Jonghwan
AU  - Jegal J
AD  - College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea. 
      Electronic address: jhjegal@pusan.ac.kr.
FAU - Park, Sang-A
AU  - Park SA
AD  - College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea. 
      Electronic address: sapark@live.co.kr.
FAU - Kim, Su-Nam
AU  - Kim SN
AD  - Natural Products Research Institute, Korea Institute of Science and Technology, 
      Gangneung 25451, Republic of Korea. Electronic address: snkim@kist.re.kr.
FAU - Yang, Min Hye
AU  - Yang MH
AD  - College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea. 
      Electronic address: mhyang@pusan.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20171216
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Dinitrochlorobenzene)
RN  - 0 (Plant Extracts)
RN  - 15646-46-5 (Oxazolone)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 3.2.1.52 (beta-N-Acetylhexosaminidases)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/chemistry/isolation & purification/*pharmacology
MH  - Cell Line, Tumor
MH  - Dermatitis, Atopic/blood/chemically induced/immunology/*prevention & control
MH  - *Dinitrochlorobenzene
MH  - Disease Models, Animal
MH  - Female
MH  - Fruit/chemistry
MH  - Immunoglobulin E/blood
MH  - Interleukin-4/blood
MH  - *Juniperus/chemistry
MH  - Mice, Hairless
MH  - Mice, Inbred BALB C
MH  - *Oxazolone
MH  - Phytotherapy
MH  - Plant Extracts/chemistry/isolation & purification/*pharmacology
MH  - Plants, Medicinal
MH  - Rats
MH  - Skin/*drug effects/immunology/metabolism
MH  - beta-N-Acetylhexosaminidases/metabolism
OTO - NOTNLM
OT  - Atopic dermatitis
OT  - Cupressuflavone
OT  - Interleukin 4
OT  - Isoscutellarein-7-O-beta-xylopyranoside
OT  - Juniperus rigida fruit
OT  - Skin barrier function
EDAT- 2017/12/21 06:00
MHDA- 2018/08/14 06:00
CRDT- 2017/12/21 06:00
PHST- 2017/05/22 00:00 [received]
PHST- 2017/12/12 00:00 [revised]
PHST- 2017/12/14 00:00 [accepted]
PHST- 2017/12/21 06:00 [pubmed]
PHST- 2018/08/14 06:00 [medline]
PHST- 2017/12/21 06:00 [entrez]
AID - S0378-8741(17)31995-5 [pii]
AID - 10.1016/j.jep.2017.12.022 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2018 Mar 25;214:160-167. doi: 10.1016/j.jep.2017.12.022. Epub 
      2017 Dec 16.