PMID- 29258957
OWN - NLM
STAT- MEDLINE
DCOM- 20181003
LR  - 20181202
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 112
DP  - 2018 Feb
TI  - Decreased macrophage phagocytic function due to xenobiotic exposures in vitro, 
      difference in sensitivity between various macrophage models.
PG  - 86-96
LID - S0278-6915(17)30766-4 [pii]
LID - 10.1016/j.fct.2017.12.024 [doi]
AB  - Both autoimmune disease prevalence and exposure to immunotoxic chemicals have 
      increased the last decades. As a first screening of immunotoxic chemicals 
      possibly affecting development of autoimmunity through attenuated macrophage 
      function, we demonstrate a promising model measuring macrophage function in 
      isolated peritoneal macrophages (PCM) from Wistar rats and C57Bl/6 mice. 
      Immunotoxic effects of bisphenol A (BPA) and a selection of perfluoroalkyl acids 
      (PFAAs) were analysed in vitro assessing phagocytic function of macrophages from 
      different sources. Phagocytosis was reduced in PCM of C57Bl/6 mice and Wistar 
      rats after BPA and perfluoroundecanoic acid (PFUnDA) exposure, but not in 
      macrophages derived from human and rat monocyte derived macrophages (MDM). On the 
      other hand, in vitro exposure to mixtures of persistent organic pollutants (POPs) 
      showed similar reductions in rat PCM and rat and human MDM phagocytosis. Reduced 
      phagocytosis was partly due to cytotoxicity. PCM isolated from non-obese diabetic 
      (NOD) mice, interleukin 1alpha/beta knockout (IL-1KO) mice and new-born rats were less 
      sensitive to the xenobiotics than PCM from adult wild type rodents. Finally, in 
      vivo studies with NOD mice verified that POP exposure also decreased the number 
      of pancreatic macrophages in pancreatic islets, reflecting early signs of 
      autoimmunity development, similarly as previously described for BPA.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Berntsen, Hanne Friis
AU  - Berntsen HF
AD  - Norwegian University of Life Sciences, Faculty of Veterinary Medicine, Oslo, 
      Norway; Department of Administration, Lab Animal Unit, National Institute of 
      Occupational Health, Oslo, Norway.
FAU - Bolling, Anette Kocbach
AU  - Bolling AK
AD  - Department of Air and Noise, Norwegian Institute of Public Health, Oslo, Norway.
FAU - Bjorklund, Cesilie Granum
AU  - Bjorklund CG
AD  - Norwegian University of Life Sciences, Faculty of Veterinary Medicine, Oslo, 
      Norway.
FAU - Zimmer, Karin
AU  - Zimmer K
AD  - Norwegian University of Life Sciences, Faculty of Veterinary Medicine, Oslo, 
      Norway.
FAU - Ropstad, Erik
AU  - Ropstad E
AD  - Norwegian University of Life Sciences, Faculty of Veterinary Medicine, Oslo, 
      Norway.
FAU - Zienolddiny, Shanbeh
AU  - Zienolddiny S
AD  - Department of Biological and Chemical Work Environment, National Institute of 
      Occupational Health, Oslo, Norway.
FAU - Becher, Rune
AU  - Becher R
AD  - Department of Air and Noise, Norwegian Institute of Public Health, Oslo, Norway.
FAU - Holme, Jorn A
AU  - Holme JA
AD  - Department of Air and Noise, Norwegian Institute of Public Health, Oslo, Norway.
FAU - Dirven, Hubert
AU  - Dirven H
AD  - Department of Toxicology and Risk Assessment, Norwegian Institute of Public 
      Health, Oslo, Norway.
FAU - Nygaard, Unni Cecilie
AU  - Nygaard UC
AD  - Department of Toxicology and Risk Assessment, Norwegian Institute of Public 
      Health, Oslo, Norway.
FAU - Bodin, Johanna
AU  - Bodin J
AD  - Department of Toxicology and Risk Assessment, Norwegian Institute of Public 
      Health, Oslo, Norway; Department of Infectious Immunology, Norwegian Institute of 
      Public Health, Oslo, Norway. Electronic address: johanna.bodin@fhi.no.
LA  - eng
PT  - Journal Article
DEP - 20171216
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fatty Acids)
RN  - 0 (Fluorocarbons)
RN  - 0 (Interleukin-1)
RN  - 0 (Phenols)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Xenobiotics)
RN  - 0 (perfluoroundecanoic acid)
RN  - MLT3645I99 (bisphenol A)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Benzhydryl Compounds/toxicity
MH  - Cell Survival/drug effects
MH  - Cells, Cultured
MH  - Environmental Pollutants/toxicity
MH  - Fatty Acids/toxicity
MH  - Female
MH  - Fluorocarbons/toxicity
MH  - Humans
MH  - Interleukin-1/genetics
MH  - Macrophages/*drug effects/immunology
MH  - Macrophages, Peritoneal/*drug effects/immunology/metabolism
MH  - Male
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred NOD
MH  - Mice, Knockout
MH  - Phagocytosis/*drug effects
MH  - Phenols/toxicity
MH  - Rats, Wistar
MH  - Tumor Necrosis Factor-alpha/metabolism
MH  - Xenobiotics/*toxicity
OTO - NOTNLM
OT  - Bisphenol A
OT  - Macrophage phagocytosis
OT  - PFOS
OT  - PFUnDA
OT  - POPs
OT  - Per- and polyfluoralkyl substances
EDAT- 2017/12/21 06:00
MHDA- 2018/10/04 06:00
CRDT- 2017/12/21 06:00
PHST- 2017/06/21 00:00 [received]
PHST- 2017/08/24 00:00 [revised]
PHST- 2017/12/15 00:00 [accepted]
PHST- 2017/12/21 06:00 [pubmed]
PHST- 2018/10/04 06:00 [medline]
PHST- 2017/12/21 06:00 [entrez]
AID - S0278-6915(17)30766-4 [pii]
AID - 10.1016/j.fct.2017.12.024 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2018 Feb;112:86-96. doi: 10.1016/j.fct.2017.12.024. Epub 2017 
      Dec 16.