PMID- 29259418
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1445-5781 (Print)
IS  - 1447-0578 (Electronic)
IS  - 1445-5781 (Linking)
VI  - 15
IP  - 1
DP  - 2016 Jan
TI  - Preimplantation genetic diagnosis/screening by comprehensive molecular testing.
PG  - 13-19
LID - 10.1007/s12522-015-0216-6 [doi]
AB  - Although embryo screening by preimplantation genetic diagnosis (PGD) has become 
      the standard technique for the treatment of recurrent pregnancy loss in couples 
      with a balanced gross chromosomal rearrangement, the implantation and pregnancy 
      rates of PGD using conventional fluorescence in situ hybridization (FISH) remain 
      suboptimal. Comprehensive molecular testing, such as array comparative genomic 
      hybridization and next-generation sequencing, can improve these rates, but 
      amplification bias in the whole genome amplification method remains an obstacle 
      to accurate diagnosis. Recent advances in amplification procedures combined with 
      improvements in the microarray platform and analytical method have overcome the 
      amplification bias, and the data accuracy of the comprehensive PGD method has 
      reached the level of clinical laboratory testing. Currently, comprehensive PGD is 
      also applied to recurrent pregnancy loss due to recurrent fetal aneuploidy or 
      infertility with recurrent implantation failure, known as preimplantation genetic 
      screening. However, there are still numerous problems to be solved, including 
      misdiagnosis due to somatic mosaicism, cell cycle-related background noise, and 
      difficulty in diagnosis of polyploidy. The technology for comprehensive PGD also 
      requires further improvement.
FAU - Kurahashi, Hiroki
AU  - Kurahashi H
AD  - Division of Molecular Genetics, Institute for Comprehensive Medical Science 
      Fujita Health University 1-98 Dengakugakubo, Kutsukake-cho 470-1192 Toyoake Aichi 
      Japan.
AD  - Genome and Transcriptome Analysis Center Fujita Health University 470-1192 
      Toyoake Aichi Japan.
FAU - Kato, Takema
AU  - Kato T
AD  - Division of Molecular Genetics, Institute for Comprehensive Medical Science 
      Fujita Health University 1-98 Dengakugakubo, Kutsukake-cho 470-1192 Toyoake Aichi 
      Japan.
FAU - Miyazaki, Jun
AU  - Miyazaki J
AD  - Division of Molecular Genetics, Institute for Comprehensive Medical Science 
      Fujita Health University 1-98 Dengakugakubo, Kutsukake-cho 470-1192 Toyoake Aichi 
      Japan.
AD  - Department of Obstetrics and Gynecology Fujita Health University School of 
      Medicine 470-1192 Toyoake Aichi Japan.
FAU - Nishizawa, Haruki
AU  - Nishizawa H
AD  - Department of Obstetrics and Gynecology Fujita Health University School of 
      Medicine 470-1192 Toyoake Aichi Japan.
FAU - Nishio, Eiji
AU  - Nishio E
AD  - Department of Obstetrics and Gynecology Fujita Health University School of 
      Medicine 470-1192 Toyoake Aichi Japan.
FAU - Furukawa, Hiroshi
AU  - Furukawa H
AD  - Department of Laboratory Medicine Fujita Health University Hospital 470-1192 
      Toyoake Aichi Japan.
FAU - Miyamura, Hironori
AU  - Miyamura H
AD  - Department of Obstetrics and Gynecology Fujita Health University School of 
      Medicine 470-1192 Toyoake Aichi Japan.
FAU - Ito, Mayuko
AU  - Ito M
AD  - Department of Obstetrics and Gynecology Fujita Health University School of 
      Medicine 470-1192 Toyoake Aichi Japan.
FAU - Endo, Toshiaki
AU  - Endo T
AD  - Department of Obstetrics and Gynecology Sapporo Medical University 060-8543 
      Sapporo Hokkaido Japan.
FAU - Ouchi, Yuya
AU  - Ouchi Y
AD  - Genome and Transcriptome Analysis Center Fujita Health University 470-1192 
      Toyoake Aichi Japan.
FAU - Inagaki, Hidehito
AU  - Inagaki H
AD  - Division of Molecular Genetics, Institute for Comprehensive Medical Science 
      Fujita Health University 1-98 Dengakugakubo, Kutsukake-cho 470-1192 Toyoake Aichi 
      Japan.
AD  - Genome and Transcriptome Analysis Center Fujita Health University 470-1192 
      Toyoake Aichi Japan.
FAU - Fujii, Takuma
AU  - Fujii T
AD  - Department of Obstetrics and Gynecology Fujita Health University School of 
      Medicine 470-1192 Toyoake Aichi Japan.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20150714
PL  - Japan
TA  - Reprod Med Biol
JT  - Reproductive medicine and biology
JID - 101213278
PMC - PMC5715840
OTO - NOTNLM
OT  - Microarray
OT  - Next-generation sequencing
OT  - Preimplantation genetic diagnosis
OT  - Recurrent pregnancy loss
OT  - Translocation
COIS- Hiroki Kurahashi, Takema Kato, Jun Miyazaki, Haruki Nishizawa, Eiji Nishio, 
      Hiroshi Furukawa, Hironori Miyamura, Mayuko Ito, Toshiaki Endo, Yuya Ouchi, 
      Hidehito Inagaki, and Takuma Fujii declare that they have no conflict of 
      interest.
EDAT- 2015/07/14 00:00
MHDA- 2015/07/14 00:01
PMCR- 2015/07/14
CRDT- 2017/12/21 06:00
PHST- 2015/05/26 00:00 [received]
PHST- 2015/07/01 00:00 [accepted]
PHST- 2017/12/21 06:00 [entrez]
PHST- 2015/07/14 00:00 [pubmed]
PHST- 2015/07/14 00:01 [medline]
PHST- 2015/07/14 00:00 [pmc-release]
AID - RMB20216 [pii]
AID - 10.1007/s12522-015-0216-6 [doi]
PST - epublish
SO  - Reprod Med Biol. 2015 Jul 14;15(1):13-19. doi: 10.1007/s12522-015-0216-6. 
      eCollection 2016 Jan.