PMID- 29260547
OWN - NLM
STAT- MEDLINE
DCOM- 20180215
LR  - 20181202
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 66
IP  - 1
DP  - 2018 Jan 10
TI  - Cognitive Improving Effects by Highbush Blueberry (Vaccinium crymbosum L.) 
      Vinegar on Scopolamine-Induced Amnesia Mice Model.
PG  - 99-107
LID - 10.1021/acs.jafc.7b03965 [doi]
AB  - The present study aimed to evaluate the preventive effects of highbush blueberry 
      (Vaccinium corymbosum L.) vinegar (BV) on cognitive functions in a scopolamine 
      (Sco)-induced amnesia model in mice. In this study, Sco (1 mg/kg, intraperitoneal 
      injection) was used to induce amnesia. ICR mice were orally administered 
      donepezil (5 mg/kg), blueberry extract (120 mg/kg), and BV (120 mg/kg) for 7 
      days. After inducing cognitive impairment by Sco, a behavioral assessment using 
      behavior tests (i.e., Y-maze and passive avoidance tests) was performed. The BV 
      group showed significantly restored cognitive function in the behavioral tests. 
      BV facilitated cholinergic activity by inhibiting acetylcholinesterase activity, 
      and enhanced antioxidant enzyme activity. Furthermore, BV was found to be 
      rehabilitated in the cornu ammonis 1 neurons of hippocampus. In our study, we 
      demonstrated that the memory protection conferred by BV was linked to activation 
      of brain-derived neurotrophic factor (BDNF)/cAMP response element binding protein 
      (CREB)/serine-threonine kinase (AKT) signaling.
FAU - Hong, Seong Min
AU  - Hong SM
AD  - BK21PLUS Glocal Education Program of Nutraceuticals Development, Konkuk 
      University , Chungju-si, Chungcheongbuk-do 27478, Republic of Korea.
FAU - Soe, Kyong Hee
AU  - Soe KH
AD  - Department of Applied Life Science, College of Biomedical and Health Science, 
      Konkuk University , Chungju-si, Chungcheongbuk-do 27478, Republic of Korea.
FAU - Lee, Taek Hwan
AU  - Lee TH
AD  - Institute of Biomedical and Health Science, Kunkuk University , Chungju-si, 
      Chungcheongbuk-do 27478, Republic of Korea.
AD  - Ahn-Gook Health., LTD. , Seoul 07445, Republic of Korea.
FAU - Kim, In Sook
AU  - Kim IS
AD  - Institute of Biomedical and Health Science, Kunkuk University , Chungju-si, 
      Chungcheongbuk-do 27478, Republic of Korea.
FAU - Lee, Young Min
AU  - Lee YM
AD  - Department of Applied Life Science, College of Biomedical and Health Science, 
      Konkuk University , Chungju-si, Chungcheongbuk-do 27478, Republic of Korea.
FAU - Lim, Beong Ou
AU  - Lim BO
AUID- ORCID: 0000-0002-9618-5956
AD  - Research Institute of Inflammatory Diseases, Kunkuk University , Chungju-si, 
      Chungcheongbuk-do 27478, Republic of Korea.
AD  - Department of Life Science, College of Biomedical and Health Science, Konkuk 
      University , 268 Chungwondaero, Chungju-si, Chungcheongbuk-do 27478, Republic of 
      Korea.
LA  - eng
PT  - Journal Article
DEP - 20171220
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Plant Extracts)
RN  - DL48G20X8X (Scopolamine)
RN  - EC 3.1.1.7 (Acetylcholinesterase)
RN  - N9YNS0M02X (Acetylcholine)
SB  - IM
MH  - Acetylcholine/metabolism
MH  - Acetylcholinesterase/metabolism
MH  - Amnesia/chemically induced/*drug therapy
MH  - Animals
MH  - Avoidance Learning/drug effects
MH  - Blueberry Plants/*chemistry
MH  - Cerebral Cortex/drug effects/metabolism
MH  - Cognition/*drug effects
MH  - Disease Models, Animal
MH  - Hippocampus/drug effects/metabolism
MH  - Maze Learning
MH  - Mice, Inbred ICR
MH  - Neuroprotective Agents/*pharmacology
MH  - Plant Extracts/chemistry/*pharmacology
MH  - Scopolamine/toxicity
OTO - NOTNLM
OT  - AChE activity
OT  - BDNF/CREB/AKT pathway
OT  - amnesia
OT  - behavior tests
OT  - blueberry vinegar
OT  - scopolamine
EDAT- 2017/12/21 06:00
MHDA- 2018/02/16 06:00
CRDT- 2017/12/21 06:00
PHST- 2017/12/21 06:00 [pubmed]
PHST- 2018/02/16 06:00 [medline]
PHST- 2017/12/21 06:00 [entrez]
AID - 10.1021/acs.jafc.7b03965 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2018 Jan 10;66(1):99-107. doi: 10.1021/acs.jafc.7b03965. Epub 
      2017 Dec 20.