PMID- 29261145 OWN - NLM STAT- MEDLINE DCOM- 20180601 LR - 20181202 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 14 IP - 12 DP - 2017 Dec 20 TI - Maternal Exposure to Air Pollutants and Risk of Gestational Diabetes Mellitus in Taiwan. LID - 10.3390/ijerph14121604 [doi] LID - 1604 AB - Mounting evidence has shown an increased risk of gestational diabetes mellitus (GDM) in association with elevated exposure to air pollution. However, limited evidence is available concerning the effect of specific air pollutant(s) on GDM incidence. We conducted this case-control study on 6717 mothers with GDM diagnosed in 2006-2013 and 6717 age- and year of delivery-matched controls to further address the risk of GDM in relation to specific air pollutant. Both cases and controls were selected from a cohort of 1-million beneficiaries of Taiwan's National Health Insurance program registered in 2005. Maternal exposures to mean daily air pollutant concentration, derived from 76 fixed air quality monitoring stations within the 12-week period prior to pregnancy and during the 1st and 2nd trimesters, were assessed by the spatial analyst method (i.e., ordinary kriging) with the ArcGIS software. After controlling for potential confounders and other air pollutants, an increase in pre-pregnancy exposure of 1 inter-quartile range (IQR) for PM(2.5) and SO(2) was found to associate with a significantly elevated odds ratio (OR) of GDM at 1.10 (95% confidence interval (CI) 1.03-1.18 and 1.37 (95% CI 1.30-1.45), respectively. Exposures to PM(2.5) and SO(2) during the 1st and 2nd trimesters were also associated with significantly increased ORs, which were 1.09 (95% CI 1.02-1.17) and 1.07 (95% CI 1.01-1.14) for PM(2.5), and 1.37 (95% CI 1.30-1.45) and 1.38 (95% CI 1.31-1.46) for SO(2). It was concluded that higher pre- and post-pregnancy exposures to PM(2.5) and SO(2) for mothers were associated with a significantly but modestly elevated risk of GDM. FAU - Shen, Hsiu-Nien AU - Shen HN AD - Department of Intensive Care Medicine, Chi Mei Medical Center, Yong-Kang District, Tainan City, Taiwan. hsiunian@gmail.com. FAU - Hua, Sheng-Yuan AU - Hua SY AD - Department of Public Health, College of Medicine, National Cheng Kung University, Tainan City, Taiwan. azureluno@hotmail.com. FAU - Chiu, Chang-Ta AU - Chiu CT AD - Department of Dentistry, An Nan Hospital, China Medical University, Tainan City, Taiwan. cyli@ntunhs.edu.tw. FAU - Li, Chung-Yi AU - Li CY AD - Department of Public Health, College of Medicine, National Cheng Kung University, Tainan City, Taiwan. cyli99@mail.ncku.edu.tw. AD - Department of Public Health, College of Public Health, China Medical University, Taichung City, Taiwan. cyli99@mail.ncku.edu.tw. LA - eng PT - Journal Article DEP - 20171220 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 RN - 0 (Air Pollutants) SB - IM MH - Adult MH - Air Pollutants/*adverse effects MH - Case-Control Studies MH - Diabetes, Gestational/epidemiology MH - Female MH - Humans MH - Incidence MH - Maternal Exposure/*adverse effects MH - Pregnancy MH - Risk MH - Taiwan/epidemiology MH - Young Adult PMC - PMC5751021 OTO - NOTNLM OT - air pollution OT - dose-response relationship OT - gestational diabetes mellitus OT - nested case-control study COIS- The authors declare no conflict of interest. EDAT- 2017/12/21 06:00 MHDA- 2018/06/02 06:00 PMCR- 2017/12/01 CRDT- 2017/12/21 06:00 PHST- 2017/10/22 00:00 [received] PHST- 2017/11/26 00:00 [revised] PHST- 2017/12/15 00:00 [accepted] PHST- 2017/12/21 06:00 [entrez] PHST- 2017/12/21 06:00 [pubmed] PHST- 2018/06/02 06:00 [medline] PHST- 2017/12/01 00:00 [pmc-release] AID - ijerph14121604 [pii] AID - ijerph-14-01604 [pii] AID - 10.3390/ijerph14121604 [doi] PST - epublish SO - Int J Environ Res Public Health. 2017 Dec 20;14(12):1604. doi: 10.3390/ijerph14121604.