PMID- 29262334
OWN - NLM
STAT- MEDLINE
DCOM- 20180720
LR  - 20220129
IS  - 2211-1247 (Electronic)
VI  - 21
IP  - 12
DP  - 2017 Dec 19
TI  - Modulation of SF1 Neuron Activity Coordinately Regulates Both Feeding Behavior 
      and Associated Emotional States.
PG  - 3559-3572
LID - S2211-1247(17)31756-4 [pii]
LID - 10.1016/j.celrep.2017.11.089 [doi]
AB  - Feeding requires the integration of homeostatic drives with emotional states 
      relevant to food procurement in potentially hostile environments. The 
      ventromedial hypothalamus (VMH) regulates feeding and anxiety, but how these are 
      controlled in a concerted manner remains unclear. Using pharmacogenetic, 
      optogenetic, and calcium imaging approaches with a battery of behavioral assays, 
      we demonstrate that VMH steroidogenic factor 1 (SF1) neurons constitute a 
      nutritionally sensitive switch, modulating the competing motivations of feeding 
      and avoidance of potentially dangerous environments. Acute alteration of SF1 
      neuronal activity alters food intake via changes in appetite and feeding-related 
      behaviors, including locomotion, exploration, anxiety, and valence. In turn, 
      intrinsic SF1 neuron activity is low during feeding and increases with both 
      feeding termination and stress. Our findings identify SF1 neurons as a key part 
      of the neurocircuitry that controls both feeding and related affective states, 
      giving potential insights into the relationship between disordered eating and 
      stress-associated psychological disorders in humans.
CI  - Copyright (c) 2017 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Viskaitis, Paulius
AU  - Viskaitis P
AD  - MRC London Institute of Medical Sciences, Du Cane Road, London W12 0NN, UK; 
      Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, Du 
      Cane Road, London W12 0NN, UK.
FAU - Irvine, Elaine E
AU  - Irvine EE
AD  - MRC London Institute of Medical Sciences, Du Cane Road, London W12 0NN, UK; 
      Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, Du 
      Cane Road, London W12 0NN, UK.
FAU - Smith, Mark A
AU  - Smith MA
AD  - MRC London Institute of Medical Sciences, Du Cane Road, London W12 0NN, UK; 
      Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, Du 
      Cane Road, London W12 0NN, UK.
FAU - Choudhury, Agharul I
AU  - Choudhury AI
AD  - MRC London Institute of Medical Sciences, Du Cane Road, London W12 0NN, UK; 
      Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, Du 
      Cane Road, London W12 0NN, UK.
FAU - Alvarez-Curto, Elisa
AU  - Alvarez-Curto E
AD  - Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems 
      Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, 
      Glasgow G12 8QQ, UK.
FAU - Glegola, Justyna A
AU  - Glegola JA
AD  - MRC London Institute of Medical Sciences, Du Cane Road, London W12 0NN, UK; 
      Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, Du 
      Cane Road, London W12 0NN, UK.
FAU - Hardy, Darran G
AU  - Hardy DG
AD  - MRC London Institute of Medical Sciences, Du Cane Road, London W12 0NN, UK; 
      Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, Du 
      Cane Road, London W12 0NN, UK.
FAU - Pedroni, Silvia M A
AU  - Pedroni SMA
AD  - MRC London Institute of Medical Sciences, Du Cane Road, London W12 0NN, UK; 
      Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, Du 
      Cane Road, London W12 0NN, UK.
FAU - Paiva Pessoa, Maria R
AU  - Paiva Pessoa MR
AD  - MRC London Institute of Medical Sciences, Du Cane Road, London W12 0NN, UK; 
      Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, Du 
      Cane Road, London W12 0NN, UK.
FAU - Fernando, Anushka B P
AU  - Fernando ABP
AD  - MRC London Institute of Medical Sciences, Du Cane Road, London W12 0NN, UK; 
      Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, Du 
      Cane Road, London W12 0NN, UK.
FAU - Katsouri, Loukia
AU  - Katsouri L
AD  - MRC London Institute of Medical Sciences, Du Cane Road, London W12 0NN, UK; 
      Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, Du 
      Cane Road, London W12 0NN, UK.
FAU - Sardini, Alessandro
AU  - Sardini A
AD  - MRC London Institute of Medical Sciences, Du Cane Road, London W12 0NN, UK; 
      Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, Du 
      Cane Road, London W12 0NN, UK.
FAU - Ungless, Mark A
AU  - Ungless MA
AD  - MRC London Institute of Medical Sciences, Du Cane Road, London W12 0NN, UK; 
      Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, Du 
      Cane Road, London W12 0NN, UK.
FAU - Milligan, Graeme
AU  - Milligan G
AD  - Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems 
      Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, 
      Glasgow G12 8QQ, UK.
FAU - Withers, Dominic J
AU  - Withers DJ
AD  - MRC London Institute of Medical Sciences, Du Cane Road, London W12 0NN, UK; 
      Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, Du 
      Cane Road, London W12 0NN, UK. Electronic address: d.withers@imperial.ac.uk.
LA  - eng
GR  - BB/K019864/1/BB_/Biotechnology and Biological Sciences Research Council/United 
      Kingdom
GR  - MC_U120085816/MRC_/Medical Research Council/United Kingdom
GR  - MC_U120097114/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PL  - United States
TA  - Cell Rep
JT  - Cell reports
JID - 101573691
RN  - 0 (RNA Splicing Factors)
RN  - 0 (Sf1 protein, mouse)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Anxiety/metabolism/*physiopathology
MH  - Appetite
MH  - Calcium/metabolism
MH  - *Emotions
MH  - Exploratory Behavior
MH  - *Feeding Behavior
MH  - Female
MH  - Hypothalamus/cytology/metabolism/*physiology
MH  - Locomotion
MH  - Male
MH  - Mice
MH  - Neurons/metabolism/*physiology
MH  - RNA Splicing Factors/genetics/metabolism
PMC - PMC5746599
OTO - NOTNLM
OT  - Ventromedial hypothalamus
OT  - affective state
OT  - chemogenetics
OT  - feeding
OT  - optogenetics
OT  - steroidogenic factor 1
OT  - stress response
EDAT- 2017/12/21 06:00
MHDA- 2018/07/22 06:00
PMCR- 2017/12/19
CRDT- 2017/12/21 06:00
PHST- 2017/07/26 00:00 [received]
PHST- 2017/10/18 00:00 [revised]
PHST- 2017/11/27 00:00 [accepted]
PHST- 2017/12/21 06:00 [entrez]
PHST- 2017/12/21 06:00 [pubmed]
PHST- 2018/07/22 06:00 [medline]
PHST- 2017/12/19 00:00 [pmc-release]
AID - S2211-1247(17)31756-4 [pii]
AID - 10.1016/j.celrep.2017.11.089 [doi]
PST - ppublish
SO  - Cell Rep. 2017 Dec 19;21(12):3559-3572. doi: 10.1016/j.celrep.2017.11.089.