PMID- 29262559
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240318
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 8
IP  - 61
DP  - 2017 Nov 28
TI  - MiR-129 blocks estrogen induction of NOTCH signaling activity in breast cancer 
      stem-like cells.
PG  - 103261-103273
LID - 10.18632/oncotarget.21143 [doi]
AB  - Stem-like cells in tumor group featured the major role in the chemotherapy 
      resistance of breast cancer, and the reduction of stem-like cells helped to 
      perish the tumor when receiving chemotherapy. Smaller stem cells number indicated 
      better therapeutic effect in vitro and in clinics, but how did miR-129 and Notch 
      signaling function in breast cancer stem-like cells (BrCSCs) were unclear yet. 
      Through using sphere forming assay and FACS sorting, we found that miR-129 
      decreased the proportion of stem-like cells in breast cancer cells. Results 
      further indicated that miR-129 degraded the Estrogen Receptor 1 (ESR1) mRNA 
      through a post-translational manner and contributed to the decline of stem-like 
      cells number, preventing tumor regeneration. Cyclin d1 and DICER 1 were proved to 
      promote Let-7 maturation, and in present study, we proved that miR-129 exhibited 
      inhibition on ESR1 and halted the cyclin d1/DICER 1 sustaining of Let-7, which 
      consequently released the Let-7 degradation of NUMB. The restoration of 
      suppressive NUMB by upregulating miR-129 resulted in NOTCH signaling inhibition. 
      In conclusion, we demonstrated the negative regulation of miR-129 on NOTCH 
      signaling activation in BrCSCs' renewal, which was achieved via continuous 
      suppression on cyclin d1/DICER1 sustaining of Let-7 level, and eventually rescued 
      the targeted inhibition of NUMB. The miR-129/ESR1 signaling played pivotal role 
      in controlling DICER1/Let-7/NOTCH cascade via cyclin d1, revealing the novel 
      mechanism of dual Let-7 in non-coding genes network.
FAU - Xiao, Guodong
AU  - Xiao G
AD  - Department of Thoracic Surgery and Oncology, The Second Department of Thoracic 
      Surgery, Cancer Center, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an 710061, China.
FAU - Li, Xiang
AU  - Li X
AD  - Department of Thoracic Surgery and Oncology, The Second Department of Thoracic 
      Surgery, Cancer Center, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an 710061, China.
FAU - Li, Gang
AU  - Li G
AD  - Department of Thoracic Surgery and Oncology, The Second Department of Thoracic 
      Surgery, Cancer Center, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an 710061, China.
FAU - Zhang, Boxiang
AU  - Zhang B
AD  - Department of Thoracic Surgery and Oncology, The Second Department of Thoracic 
      Surgery, Cancer Center, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an 710061, China.
FAU - Xu, Chongwen
AU  - Xu C
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of Xi'an 
      Jiaotong University, Xi'an 710061, China.
FAU - Qin, Sida
AU  - Qin S
AD  - Department of Thoracic Surgery and Oncology, The Second Department of Thoracic 
      Surgery, Cancer Center, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an 710061, China.
FAU - Du, Ning
AU  - Du N
AD  - Department of Thoracic Surgery and Oncology, The Second Department of Thoracic 
      Surgery, Cancer Center, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an 710061, China.
FAU - Wang, Jichang
AU  - Wang J
AD  - Department of Vascular and Endovascular Surgery, The First Affiliated Hospital of 
      Xi'an Jiaotong University, Xi'an 710061, China.
FAU - Tang, Shou-Ching
AU  - Tang SC
AD  - Breast Cancer Program and Interdisciplinary Translational Research Team, Georgia 
      Regents University Cancer Center, Augusta, Georgia 30912, United States.
AD  - Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
FAU - Zhang, Jing
AU  - Zhang J
AD  - Department of Thoracic Surgery and Oncology, The Second Department of Thoracic 
      Surgery, Cancer Center, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an 710061, China.
FAU - Ren, Hong
AU  - Ren H
AD  - Department of Thoracic Surgery and Oncology, The Second Department of Thoracic 
      Surgery, Cancer Center, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an 710061, China.
FAU - Chen, Ke
AU  - Chen K
AD  - Department of Urology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430022, China.
FAU - Sun, Xin
AU  - Sun X
AD  - Department of Thoracic Surgery and Oncology, The Second Department of Thoracic 
      Surgery, Cancer Center, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an 710061, China.
LA  - eng
PT  - Journal Article
DEP - 20170921
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
PMC - PMC5732725
OTO - NOTNLM
OT  - DICER1
OT  - ESR1
OT  - Let-7
OT  - NOTCH signaling
OT  - miR-129
COIS- CONFLICTS OF INTEREST All co-authors implicated in this research approved this 
      article to be published. All authors implicated in this research declared that 
      there are no conflicts of interest.
EDAT- 2017/12/22 06:00
MHDA- 2017/12/22 06:01
PMCR- 2017/11/28
CRDT- 2017/12/22 06:00
PHST- 2017/03/24 00:00 [received]
PHST- 2017/08/08 00:00 [accepted]
PHST- 2017/12/22 06:00 [entrez]
PHST- 2017/12/22 06:00 [pubmed]
PHST- 2017/12/22 06:01 [medline]
PHST- 2017/11/28 00:00 [pmc-release]
AID - 21143 [pii]
AID - 10.18632/oncotarget.21143 [doi]
PST - epublish
SO  - Oncotarget. 2017 Sep 21;8(61):103261-103273. doi: 10.18632/oncotarget.21143. 
      eCollection 2017 Nov 28.