PMID- 29262661
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 8
IP  - 61
DP  - 2017 Nov 28
TI  - Resting-state functional magnetic resonance imaging shows altered brain network 
      topology in Type 2 diabetic patients without cognitive impairment.
PG  - 104560-104570
LID - 10.18632/oncotarget.21282 [doi]
AB  - We analyzed topology of brain functional networks in type 2 diabetes mellitus 
      (T2DM) patients without mild cognitive impairment. We recruited T2DM patients 
      without mild cognitive impairment (4 males and 8 females) and healthy control 
      subjects (8 males and 16 females) to undergo cognitive testing and resting-state 
      functional magnetic resonance imaging. Graph theoretical analysis of functional 
      brain networks revealed abnormal small-world architecture in T2DM patients as 
      compared to control subjects. The functional brain networks of T2DM patients 
      showed increased path length, decreased global efficiency and disrupted 
      long-distance connections. Moreover, reduced nodal characteristics were 
      distributed in the frontal, parietal and temporal lobes, while increased nodal 
      characteristics were distributed in the frontal, occipital lobes, and basal 
      ganglia in the T2DM patients. The disrupted topological properties correlated 
      with cognitive performance of T2DM patients. These findings demonstrate altered 
      topological organization of functional brain networks in T2DM patients without 
      mild cognitive impairment.
FAU - Chen, Guan-Qun
AU  - Chen GQ
AD  - Department of Neurology, XuanWu Hospital, Capital Medical University, Beijing, 
      China.
AD  - Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, 
      China.
AD  - National Clinical Research Center for Geriatric Disorders, Beijing, China.
FAU - Zhang, Xin
AU  - Zhang X
AD  - Department of Radiology, Tangdu Hospital, The Fourth Military Medical University, 
      Xi'an, China.
FAU - Xing, Yue
AU  - Xing Y
AD  - Radiological Sciences, Division of Clinical Neuroscience, Queen's Medical Centre, 
      University of Nottingham, Nottingham, United Kingdom.
AD  - Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, 
      Nottingham, United Kingdom.
FAU - Wen, Dong
AU  - Wen D
AD  - School of Information Science and Engineering, Yanshan University, Qinhuangdao, 
      China.
AD  - The Key Laboratory of Software Engineering of Hebei Province, Yanshan University, 
      Qinhuangdao, China.
FAU - Cui, Guang-Bin
AU  - Cui GB
AD  - Department of Radiology, Tangdu Hospital, The Fourth Military Medical University, 
      Xi'an, China.
FAU - Han, Ying
AU  - Han Y
AD  - Department of Neurology, XuanWu Hospital, Capital Medical University, Beijing, 
      China.
AD  - Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, 
      China.
AD  - National Clinical Research Center for Geriatric Disorders, Beijing, China.
AD  - Beijing Institute of Geriatrics, Beijing, China.
AD  - PKUCare Rehabilitation Hospital, Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20170927
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
PMC - PMC5732827
OTO - NOTNLM
OT  - brain network
OT  - cognitive dysfunction
OT  - functional connectivity
OT  - resting-state functional magnetic resonance imaging
OT  - type 2 diabetes mellitus
COIS- CONFLICTS OF INTEREST The authors declare that there are no conflicts of 
      interest.
EDAT- 2017/12/22 06:00
MHDA- 2017/12/22 06:01
PMCR- 2017/11/28
CRDT- 2017/12/22 06:00
PHST- 2017/02/18 00:00 [received]
PHST- 2017/08/25 00:00 [accepted]
PHST- 2017/12/22 06:00 [entrez]
PHST- 2017/12/22 06:00 [pubmed]
PHST- 2017/12/22 06:01 [medline]
PHST- 2017/11/28 00:00 [pmc-release]
AID - 21282 [pii]
AID - 10.18632/oncotarget.21282 [doi]
PST - epublish
SO  - Oncotarget. 2017 Sep 27;8(61):104560-104570. doi: 10.18632/oncotarget.21282. 
      eCollection 2017 Nov 28.