PMID- 29264566
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2472-1972 (Print)
IS  - 2472-1972 (Electronic)
IS  - 2472-1972 (Linking)
VI  - 1
IP  - 9
DP  - 2017 Sep 1
TI  - Insulinoma and Tuberous Sclerosis: A Possible Mechanistic Target of Rapamycin 
      (mTOR) Pathway Abnormality?
PG  - 1120-1123
LID - 10.1210/js.2017-00160 [doi]
AB  - A 23-year-old New Zealand Maori male with tuberous sclerosis (TSC) and associated 
      neurocognitive abnormalities presented with altered behavior and increasing 
      seizure frequency. Endogenous hyperinsulinemia from an underlying insulinoma was 
      confirmed and this was managed surgically. This case represents only the sixth 
      description of insulinoma in TSC to date. The role of the hamartin-tuberin 
      complex in regulation of the mechanistic target of rapamycin pathway provides a 
      plausible pathogenetic mechanism between insulinoma and TSC. This rare disease 
      association should be considered in TSC patients who present with otherwise 
      unexplained worsening neurocognitive symptoms.
FAU - Kang, Michael Yoon
AU  - Kang MY
AD  - Department of General Medicine, Middlemore Hospital, Auckland 2104, New Zealand.
FAU - Yeoh, Joey
AU  - Yeoh J
AD  - Department of General Medicine, Middlemore Hospital, Auckland 2104, New Zealand.
AD  - Department of Endocrinology, Middlemore Hospital, Auckland 2104, New Zealand.
FAU - Pondicherry, Ashwini
AU  - Pondicherry A
AD  - Department of General Surgery, Middlemore Hospital, Auckland 2104, New Zealand.
FAU - Rahman, Habib
AU  - Rahman H
AD  - Department of General Surgery, Middlemore Hospital, Auckland 2104, New Zealand.
FAU - Dissanayake, Ajith
AU  - Dissanayake A
AD  - Department of Endocrinology, Middlemore Hospital, Auckland 2104, New Zealand.
LA  - eng
PT  - Case Reports
DEP - 20170717
PL  - United States
TA  - J Endocr Soc
JT  - Journal of the Endocrine Society
JID - 101697997
PMC - PMC5686638
OTO - NOTNLM
OT  - insulinoma
OT  - mTOR pathway
OT  - neoplasia
OT  - tuberous sclerosis
EDAT- 2017/12/22 06:00
MHDA- 2017/12/22 06:01
PMCR- 2017/07/17
CRDT- 2017/12/22 06:00
PHST- 2017/04/07 00:00 [received]
PHST- 2017/07/12 00:00 [accepted]
PHST- 2017/12/22 06:00 [entrez]
PHST- 2017/12/22 06:00 [pubmed]
PHST- 2017/12/22 06:01 [medline]
PHST- 2017/07/17 00:00 [pmc-release]
AID - JS_201700160 [pii]
AID - 10.1210/js.2017-00160 [doi]
PST - epublish
SO  - J Endocr Soc. 2017 Jul 17;1(9):1120-1123. doi: 10.1210/js.2017-00160. eCollection 
      2017 Sep 1.