PMID- 29265684 OWN - NLM STAT- MEDLINE DCOM- 20180817 LR - 20181113 IS - 1526-9914 (Electronic) IS - 1526-9914 (Linking) VI - 19 IP - 1 DP - 2018 Jan TI - Investigation of the radiation dose from cone-beam CT for image-guided radiotherapy: A comparison of methodologies. PG - 174-183 LID - 10.1002/acm2.12239 [doi] AB - Four methodologies were evaluated for quantifying kilovoltage cone-beam computed tomography (CBCT) dose: the Cone-Beam Dose Index (CBDI), IAEA Report 5 recommended methodology (IAEA), the AAPM Task Group 111 methodology (TG111), and the current dose metric; the Computed Tomography Dose Index (CTDI) on two commercial Varian cone-beam CT imaging systems; the Clinac iX On-Board Imager (OBI); and the TrueBeam X-ray Imaging system (XI). The TG111 methodology measured the highest overall dose (21.199 +/- 0.035 mGy OBI and 22.420 +/- 0.002 XI for pelvis imaging) due to the full scatter of the TG111 phantom and was within 5% of CTDI measurements taken using a full scatter TG111 phantom and 30-cm film strips. CBDI measured the second highest overall dose, within 10% of the TG111, with IAEA measuring the third highest dose. For head CBCT protocols, CBDI measured the highest dose, followed by IAEA. The CTDI method measured lowest across all scan modes highlighting its limitations for CBCT dosimetry. The XI imaging system delivered lower doses for head and thorax scan modes and similar doses to the OBI system for pelvis scan modes due to additional beam hardening filtration in the XI system. The TG111 method measured the highest dose in the center of a CBCT scan during image guidance procedures; however, CBDI provided a good approximation to TG111 with existing CTDI equipment and may be more applicable clinically. CI - (c) 2017 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine. FAU - Buckley, Jarryd G AU - Buckley JG AD - School of Physics, Centre for Medical and Radiation Physics, University of Wollongong, Wollongong, Australia. FAU - Wilkinson, Dean AU - Wilkinson D AD - Illawarra Cancer Care Centre, Wollongong Hospital, Wollongong, Australia. FAU - Malaroda, Alessandra AU - Malaroda A AD - School of Physics, Centre for Medical and Radiation Physics, University of Wollongong, Wollongong, Australia. FAU - Metcalfe, Peter AU - Metcalfe P AD - School of Physics, Centre for Medical and Radiation Physics, University of Wollongong, Wollongong, Australia. LA - eng PT - Comparative Study PT - Journal Article DEP - 20171219 PL - United States TA - J Appl Clin Med Phys JT - Journal of applied clinical medical physics JID - 101089176 SB - IM MH - Cone-Beam Computed Tomography/*methods MH - Head/diagnostic imaging MH - Humans MH - Image Processing, Computer-Assisted/methods MH - Neoplasms/*radiotherapy MH - Organs at Risk/radiation effects MH - Pelvis/diagnostic imaging MH - *Phantoms, Imaging MH - Radiography, Thoracic MH - Radiotherapy Dosage MH - Radiotherapy Planning, Computer-Assisted/*methods MH - Radiotherapy, Image-Guided/*methods MH - Radiotherapy, Intensity-Modulated/*methods PMC - PMC5768018 OTO - NOTNLM OT - computed tomography dose index OT - cone beam computed tomography OT - gafchromic film OT - image guided radiotherapy OT - radiotherapy EDAT- 2017/12/22 06:00 MHDA- 2018/08/18 06:00 PMCR- 2017/12/19 CRDT- 2017/12/22 06:00 PHST- 2017/09/21 00:00 [received] PHST- 2017/10/31 00:00 [revised] PHST- 2017/11/03 00:00 [accepted] PHST- 2017/12/22 06:00 [pubmed] PHST- 2018/08/18 06:00 [medline] PHST- 2017/12/22 06:00 [entrez] PHST- 2017/12/19 00:00 [pmc-release] AID - ACM212239 [pii] AID - 10.1002/acm2.12239 [doi] PST - ppublish SO - J Appl Clin Med Phys. 2018 Jan;19(1):174-183. doi: 10.1002/acm2.12239. Epub 2017 Dec 19.