PMID- 29266345
OWN - NLM
STAT- MEDLINE
DCOM- 20190916
LR  - 20221207
IS  - 1440-1681 (Electronic)
IS  - 0305-1870 (Linking)
VI  - 45
IP  - 6
DP  - 2018 Jun
TI  - Hyperuricaemia and development of type 2 diabetes mellitus in Asian population.
PG  - 499-506
LID - 10.1111/1440-1681.12911 [doi]
AB  - Recently, meta-analysis studies reported that hyperuricaemia is associated with 
      higher incidence of type 2 diabetes mellitus (T2DM), however, there are limited 
      data on the Asian population. The aim of this observational study is to estimate 
      the long-term impact of hyperuricaemia on the new-onset T2DM and cardiovascular 
      events. This study is based on a single-centre, all-comers, and large 
      retrospective cohort. Subjects that visited from January 2004 to February 2014 
      were enrolled using the electronic database of Korea University Guro Hospital. A 
      total of 10 505 patients without a history of T2DM were analyzed for uric acid, 
      fasting glucose and haemoglobin (Hb) A1c level. Inclusion criteria included both 
      Hb A1c <5.7% and fasting glucose level <100 mg/dL without T2DM. Hyperuricaemia 
      was defined as a uric acid level >/=7.0 mg/dL in men, and >/=6.5 mg/dL in women. To 
      adjust baseline confounders, a propensity score matching (PSM) analysis was 
      performed. The impact of hyperuricaemia on the new-onset T2DM and cardiovascular 
      events were compared with the non-hyperuricaemia during the 5-year clinical 
      follow-up. After PSM, baseline characteristics of both groups were balanced. In a 
      5-year follow-up, the hyperuricaemia itself was a strong independent predictor of 
      the incidence of new-onset T2DM (HR, 1.78; 95% CI, 1.12 to 2.8). Hyperuricaemia 
      was a strong independent predictor of new-onset T2DM, which suggests a 
      substantial implication for a correlation between uric acid concentration and 
      insulin resistance (or insulin sensitivity). Also, hyperuricaemia is 
      substantially implicated in cardiovascular risks and the further long-term 
      cardiovascular events in the crude population, but it is not an independent 
      predictor of long-term cardiovascular mortality in the matched population.
CI  - (c) 2017 John Wiley & Sons Australia, Ltd.
FAU - Choi, Byoung Geol
AU  - Choi BG
AD  - Department of Medicine, Korea University Graduate School, Seoul, Korea.
FAU - Kim, Dae Jin
AU  - Kim DJ
AD  - Department of Integrated Biomedical and Life Sciences, Korea University Graduate 
      School, Seoul, Korea.
FAU - Baek, Man Jong
AU  - Baek MJ
AD  - Department of Thoracic and Cardiovascular Surgery, Guro Hospital, Seoul, Korea.
FAU - Ryu, Yang Gi
AU  - Ryu YG
AD  - Department of Thoracic and Cardiovascular Surgery, Guro Hospital, Seoul, Korea.
FAU - Kim, Suhng Wook
AU  - Kim SW
AD  - Department of Integrated Biomedical and Life Sciences, Korea University Graduate 
      School, Seoul, Korea.
FAU - Lee, Min Woo
AU  - Lee MW
AD  - Department of Integrated Biomedical and Life Sciences, Korea University Graduate 
      School, Seoul, Korea.
FAU - Park, Ji Young
AU  - Park JY
AD  - Division of Cardiology, Nown Eulji Hospital, Eulji University, Seoul, Korea.
FAU - Noh, Yung-Kyun
AU  - Noh YK
AD  - School of Mechanical & Aerospace Engineering, Seoul National University, Seoul, 
      Korea.
FAU - Choi, Se Yeon
AU  - Choi SY
AD  - Department of Medicine, Korea University Graduate School, Seoul, Korea.
FAU - Byun, Jae Kyeong
AU  - Byun JK
AD  - Department of Medicine, Korea University Graduate School, Seoul, Korea.
FAU - Shim, Min Suk
AU  - Shim MS
AD  - Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea.
FAU - Mashaly, Ahmed
AU  - Mashaly A
AD  - Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea.
FAU - Li, Hu
AU  - Li H
AD  - Department of Medicine, Korea University Graduate School, Seoul, Korea.
FAU - Park, Yoonjee
AU  - Park Y
AD  - Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea.
FAU - Jang, Won Young
AU  - Jang WY
AD  - Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea.
FAU - Kim, Woohyeun
AU  - Kim W
AD  - Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea.
FAU - Kang, Jun Hyuk
AU  - Kang JH
AD  - Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea.
FAU - Choi, Jah Yeon
AU  - Choi JY
AD  - Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea.
FAU - Park, Eun Jin
AU  - Park EJ
AD  - Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea.
FAU - Park, Sung-Hun
AU  - Park SH
AD  - Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea.
FAU - Lee, Sunki
AU  - Lee S
AD  - Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea.
FAU - Na, Jin Oh
AU  - Na JO
AD  - Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea.
FAU - Choi, Cheol Ung
AU  - Choi CU
AD  - Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea.
FAU - Kim, Eung Ju
AU  - Kim EJ
AD  - Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea.
FAU - Park, Chang Gyu
AU  - Park CG
AD  - Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea.
FAU - Seo, Hong Seog
AU  - Seo HS
AD  - Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea.
FAU - Oh, Dong Joo
AU  - Oh DJ
AD  - Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea.
FAU - Rha, Seung-Woon
AU  - Rha SW
AUID- ORCID: 0000-0001-9456-9852
AD  - Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea.
LA  - eng
PT  - Journal Article
DEP - 20180204
PL  - Australia
TA  - Clin Exp Pharmacol Physiol
JT  - Clinical and experimental pharmacology & physiology
JID - 0425076
SB  - IM
CIN - Clin Exp Pharmacol Physiol. 2018 Aug;45(8):870. PMID: 29570819
MH  - Aged
MH  - Asian People/*statistics & numerical data
MH  - Diabetes Mellitus, Type 2/*complications/epidemiology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hyperuricemia/*complications
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
OTO - NOTNLM
OT  - diabetes mellitus
OT  - hyperuricaemia
OT  - risk factors
OT  - uric acid
EDAT- 2017/12/22 06:00
MHDA- 2019/09/17 06:00
CRDT- 2017/12/22 06:00
PHST- 2017/03/13 00:00 [received]
PHST- 2017/12/04 00:00 [revised]
PHST- 2017/12/06 00:00 [accepted]
PHST- 2017/12/22 06:00 [pubmed]
PHST- 2019/09/17 06:00 [medline]
PHST- 2017/12/22 06:00 [entrez]
AID - 10.1111/1440-1681.12911 [doi]
PST - ppublish
SO  - Clin Exp Pharmacol Physiol. 2018 Jun;45(6):499-506. doi: 10.1111/1440-1681.12911. 
      Epub 2018 Feb 4.