PMID- 29266595
OWN - NLM
STAT- MEDLINE
DCOM- 20190326
LR  - 20190326
IS  - 1098-1063 (Electronic)
IS  - 1050-9631 (Linking)
VI  - 28
IP  - 3
DP  - 2018 Mar
TI  - Differential modulation of CA1 impulse flow by endogenous serotonin along the 
      hippocampal longitudinal axis.
PG  - 217-225
LID - 10.1002/hipo.22825 [doi]
AB  - The hippocampus is functionally differentiated along its longitudinal axis, with 
      the dorsal and ventral segments preferentially involved in cognitive and 
      emotional processing, respectively. Serotonergic modulation of hippocampal 
      function has been extensively studied, but its relation to the dorsoventral axis 
      has remained largely unknown. To examine the modulation of hippocampal output 
      along the dorsoventral axis by endogenous serotonin (5-HT) we compared the effect 
      of the 5-HT/noradrenaline (NA)-releaser, 3,4-methylenedioxymethamphetamine 
      (MDMA), in transversal slices encompassing the entire rat hippocampus. Co-release 
      of 5-HT and NA by MDMA resulted in a gradient of effects on evoked population 
      spikes in the CA1 area along the dorsoventral axis of the hippocampus. Selective 
      5-HT release decreased population spike amplitude in slices from dorsal 
      hippocampus, whereas an increase was produced in the ventral hippocampus, 
      indicating differential modulation of CA1 impulse flow along the dorsoventral 
      axis by endogenous 5-HT. Selective NA release increased population spike 
      amplitude with no gradient indicating facilitatory effect of endogenous NA along 
      the entire dorsoventral axis. Blockade of 5-HT(1A) receptors prevented the 
      inhibitory component of MDMA action and the emergence of the gradient, indicating 
      that activation of 5-HT(1A) receptors is required for differential modulation of 
      CA1 impulse flow by endogenous 5-HT. These findings suggest that a dorsoventral 
      shift in CA1 output level may represent an integral component of 5-HT action on 
      hippocampal information processing. Given the preferential role of ventral 
      hippocampus in emotional and anxiety-related behavior, it can be proposed that 
      serotonin tone encodes the emotional salience of the signal processed by 
      hippocampus.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Mlinar, Boris
AU  - Mlinar B
AUID- ORCID: 0000-0001-9082-0827
AD  - Department of Neuroscience, Psychology, Drug Research and Child Health, 
      University of Florence, Florence, Italy.
FAU - Corradetti, Renato
AU  - Corradetti R
AUID- ORCID: 0000-0002-2588-0484
AD  - Department of Neuroscience, Psychology, Drug Research and Child Health, 
      University of Florence, Florence, Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180110
PL  - United States
TA  - Hippocampus
JT  - Hippocampus
JID - 9108167
RN  - 0 (Adrenergic Uptake Inhibitors)
RN  - 0 (Piperazines)
RN  - 0 (Pyridines)
RN  - 0 (Serotonin Agents)
RN  - 112692-38-3 (Receptor, Serotonin, 5-HT1A)
RN  - 333DO1RDJY (Serotonin)
RN  - 71IH826FEG 
      (N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Adrenergic Uptake Inhibitors/pharmacology
MH  - Animals
MH  - Hippocampus/drug effects/*metabolism
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/pharmacology
MH  - Norepinephrine/metabolism
MH  - Piperazines/pharmacology
MH  - Pyridines/pharmacology
MH  - Rats, Wistar
MH  - Receptor, Serotonin, 5-HT1A/metabolism
MH  - Serotonin/*metabolism
MH  - Serotonin Agents/pharmacology
MH  - Synaptic Transmission/drug effects/physiology
MH  - Tissue Culture Techniques
OTO - NOTNLM
OT  - 5-HT1A receptor
OT  - MDMA
OT  - noradrenaline
OT  - population spike
OT  - rat (RRID:RGD_68115)
EDAT- 2017/12/22 06:00
MHDA- 2019/03/27 06:00
CRDT- 2017/12/22 06:00
PHST- 2017/04/22 00:00 [received]
PHST- 2017/12/11 00:00 [revised]
PHST- 2017/12/14 00:00 [accepted]
PHST- 2017/12/22 06:00 [pubmed]
PHST- 2019/03/27 06:00 [medline]
PHST- 2017/12/22 06:00 [entrez]
AID - 10.1002/hipo.22825 [doi]
PST - ppublish
SO  - Hippocampus. 2018 Mar;28(3):217-225. doi: 10.1002/hipo.22825. Epub 2018 Jan 10.