PMID- 29267510
OWN - NLM
STAT- MEDLINE
DCOM- 20181009
LR  - 20220408
IS  - 2238-0019 (Electronic)
IS  - 2237-6089 (Linking)
VI  - 39
IP  - 4
DP  - 2017 Oct-Dec
TI  - Clinical and familial profile of bipolar disorder with and without 
      obsessive-compulsive disorder: an Indian study.
PG  - 270-275
LID - S2237-60892017000400270 [pii]
LID - 10.1590/2237-6089-2017-0061 [doi]
AB  - INTRODUCTION: Comorbid obsessive-compulsive disorder (OCD) is common in bipolar 
      disorder (BD). Clinical characteristics, functionality and familial pattern of 
      this comorbidity are largely understudied. OBJECTIVE: To assess clinical profile, 
      familial loading of psychiatric disorders and level of functioning in remitted BD 
      patients who have comorbid OCD and to compare results with those of remitted BD 
      patients without OCD. METHODS: Remitted BD-I subjects were assessed using the 
      Structured Clinical Interview for DSM-IV Axis I Disorders, Global Assessment of 
      Functioning Scale (GAF), Hamilton Depression Rating Scale (HDRS), Young Mania 
      Rating Scale (YMRS), Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) and Family 
      Interview for Genetic Studies (FIGS). BD patients with and without OCD were 
      compared. Group differences were analyzed using the chi-square test and the 
      independent samples t test. Values <0.05 were considered statistically 
      significant. RESULTS: Of the 90 remitted BD-I patients, 35.5% (n=32) had 
      obsessive-compulsive symptoms/OCD. The BD-OCD group showed significantly lower 
      GAF scores, higher rates of suicidal attempts, hospitalizations, manic and 
      depressive episodes compared to the group with BD only (p<0.05). In addition, 
      first and second-degree relatives had higher rates of BD-OCD and OCD, but not of 
      BD. CONCLUSIONS: BD-OCD is characterized by more severe BD, more dysfunction and 
      higher familial loading of BD-OCD and OCD. Larger studies involving relatives of 
      probands will help to confirm our findings and to delineate nosological status of 
      BD-OCD comorbidity.
FAU - Kazhungil, Firoz
AU  - Kazhungil F
AD  - Department of Psychiatry, Government Medical College, Kozhikode, Kerala, India.
FAU - Cholakottil, Ajitha
AU  - Cholakottil A
AD  - Department of Psychiatry, Government Medical College, Manjeri, Kerala, India.
FAU - Kattukulathil, Shihab
AU  - Kattukulathil S
AD  - Department of Psychiatry, Government Medical College, Manjeri, Kerala, India.
FAU - Kottelassal, Abdurazak
AU  - Kottelassal A
AD  - Department of Psychiatry, Government Medical College, Manjeri, Kerala, India.
FAU - Vazhakalayil, Rajeesh
AU  - Vazhakalayil R
AD  - Department of Psychiatry, Government Medical College, Manjeri, Kerala, India.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Brazil
TA  - Trends Psychiatry Psychother
JT  - Trends in psychiatry and psychotherapy
JID - 101610695
SB  - IM
MH  - Adult
MH  - Bipolar Disorder/*complications/*epidemiology/psychology/therapy
MH  - Comorbidity
MH  - Cost of Illness
MH  - Family
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Hospitalization
MH  - Humans
MH  - Interview, Psychological
MH  - Male
MH  - Obsessive-Compulsive Disorder/*complications/*epidemiology/psychology/therapy
MH  - Prevalence
MH  - Psychiatric Status Rating Scales
MH  - Suicide, Attempted
EDAT- 2017/12/22 06:00
MHDA- 2018/10/10 06:00
CRDT- 2017/12/22 06:00
PHST- 2017/05/13 00:00 [received]
PHST- 2017/07/30 00:00 [accepted]
PHST- 2017/12/22 06:00 [entrez]
PHST- 2017/12/22 06:00 [pubmed]
PHST- 2018/10/10 06:00 [medline]
AID - S2237-60892017000400270 [pii]
AID - 10.1590/2237-6089-2017-0061 [doi]
PST - ppublish
SO  - Trends Psychiatry Psychother. 2017 Oct-Dec;39(4):270-275. doi: 
      10.1590/2237-6089-2017-0061.