PMID- 29271292
OWN - NLM
STAT- MEDLINE
DCOM- 20180702
LR  - 20240324
IS  - 1753-9455 (Electronic)
IS  - 1753-9447 (Print)
IS  - 1753-9447 (Linking)
VI  - 12
IP  - 2
DP  - 2018 Feb
TI  - Chronic limb-threatening ischemia could benefit from growth hormone therapy for 
      wound healing and limb salvage.
PG  - 53-72
LID - 10.1177/1753944717745494 [doi]
AB  - Revascularization for chronic limb-threatening ischemia (CLTI) is necessary to 
      alleviate symptoms and wound healing. When it fails or is not possible, there are 
      few alternatives to avoid limb amputation in these patients. Although 
      experimental studies with stem cells and growth factors have shown promise, 
      clinical trials have demonstrated inconsistent results because CLTI patients 
      generally need arteriogenesis rather than angiogenesis. Moreover, in addition to 
      the perfusion of the limb, there is the need to improve the neuropathic response 
      for wound healing, especially in diabetic patients. Growth hormone (GH) is a 
      pleiotropic hormone capable of boosting the aforementioned processes and adds 
      special benefits for the redox balance. This hormone has the potential to 
      mitigate symptoms in ischemic patients with no other options and improves the 
      cardiovascular complications associated with the disease. Here, we discuss the 
      pros and cons of using GH in such patients, focus on its effects on peripheral 
      arteries, and analyze the possible benefits of treating CLTI with this hormone.
FAU - Caicedo, Diego
AU  - Caicedo D
AUID- ORCID: 0000-0002-9599-7047
AD  - Department of Angiology and Vascular Surgery, Complexo Hospitalario Universitario 
      de Pontevedra, Avda. de Mourente, s/n; 36071-Pontevedra, Spain.
AD  - Scientific Direction, Medical Center Foltra. Travesia Montouto, 24; 15710-Teo, A 
      Coruna, 15886, Spain.
FAU - Devesa, Pablo
AU  - Devesa P
AD  - Research and Development Medical Center Foltra, Teo, Spain.
AD  - Scientific Direction, Medical Center Foltra. Travesia Montouto, 24; 15710-Teo, A 
      Coruna, 15886, Spain.
FAU - Arce, Victor M
AU  - Arce VM
AD  - Department of Physiology, Santiago University School of Medicine, Spain.
AD  - Scientific Direction, Medical Center Foltra. Travesia Montouto, 24; 15710-Teo, A 
      Coruna, 15886, Spain.
FAU - Requena, Julia
AU  - Requena J
AD  - Department of Angiology and Vascular Surgery, Complexo Hospitalario Universitario 
      de Pontevedra, Spain.
AD  - Scientific Direction, Medical Center Foltra. Travesia Montouto, 24; 15710-Teo, A 
      Coruna, 15886, Spain.
FAU - Devesa, Jesus
AU  - Devesa J
AD  - Scientific Direction, Medical Center Foltra. Travesia Montouto, 24; 15710-Teo, A 
      Coruna, 15886, Spain.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20171222
PL  - England
TA  - Ther Adv Cardiovasc Dis
JT  - Therapeutic advances in cardiovascular disease
JID - 101316343
RN  - 0 (Angiogenesis Inducing Agents)
RN  - 12629-01-5 (Human Growth Hormone)
SB  - IM
MH  - Angiogenesis Inducing Agents/adverse effects/*therapeutic use
MH  - Animals
MH  - Chronic Disease
MH  - Computed Tomography Angiography
MH  - Human Growth Hormone/adverse effects/*therapeutic use
MH  - Humans
MH  - Ischemia/diagnostic imaging/*drug therapy/physiopathology
MH  - Limb Salvage/adverse effects/*methods
MH  - Lower Extremity/*blood supply
MH  - Neovascularization, Physiologic/*drug effects
MH  - Peripheral Arterial Disease/diagnostic imaging/*drug therapy/physiopathology
MH  - Regional Blood Flow
MH  - Treatment Outcome
MH  - Wound Healing/*drug effects
PMC - PMC5772430
OTO - NOTNLM
OT  - angiogenesis
OT  - arteriogenesis
OT  - chronic limb-threatening ischemia
OT  - growth hormone
OT  - neuropathic response
OT  - redox balance
OT  - wound healing
COIS- Conflict of interest statement: The authors declare that there is no conflict of 
      interest.
EDAT- 2017/12/23 06:00
MHDA- 2018/07/03 06:00
PMCR- 2018/02/01
CRDT- 2017/12/23 06:00
PHST- 2017/12/23 06:00 [pubmed]
PHST- 2018/07/03 06:00 [medline]
PHST- 2017/12/23 06:00 [entrez]
PHST- 2018/02/01 00:00 [pmc-release]
AID - 10.1177_1753944717745494 [pii]
AID - 10.1177/1753944717745494 [doi]
PST - ppublish
SO  - Ther Adv Cardiovasc Dis. 2018 Feb;12(2):53-72. doi: 10.1177/1753944717745494. 
      Epub 2017 Dec 22.