PMID- 29272011
OWN - NLM
STAT- MEDLINE
DCOM- 20191219
LR  - 20191219
IS  - 2284-0729 (Electronic)
IS  - 1128-3602 (Linking)
VI  - 21
IP  - 24
DP  - 2017 Dec
TI  - The non-motor symptoms of Parkinson's disease of different motor types in early 
      stage.
PG  - 5745-5750
LID - 14021 [pii]
LID - 10.26355/eurrev_201712_14021 [doi]
AB  - OBJECTIVE: We aimed to compare the different non-motor symptoms of different 
      motor phenotype Parkinson's disease (PD) at an early stage. PATIENTS AND METHODS: 
      From January 2013 to November 2016, 120 cases of PD patients who were 
      hospitalized in Neurology Department of the First Hospital of Huai'an in Jiangsu 
      Province and 120 cases of healthy controls with matched age and gender, were 
      included into the research. PD patients were administered with Non-Motor symptom 
      questionnaire (NMSQuest), the Unified Parkinson's Disease Rating Scale III 
      (UPDRS-III), the Mini-Mental State Examination score (MMSE), the Hoehn-Yahr 
      classification, the MoCA, and GDS-15. The relationship between NMS burden and PD 
      subtypes, age, gender and disease severity were examined using linear regression 
      models. The prevalence of each NMS among different PD motor subtypes was analyzed 
      using x2 test. RESULTS: Compared with the healthy controls, PD patients had a 
      higher number of NMS. The prevalence of NMS in postural instability gait 
      difficulty (PIGD) group is higher than that in tremor dominant (TD) group. There 
      is no significant correlation between age, gender, MMSE scores, MoCA scores and 
      the number of NMS. PD patients with higher UPDRS-III scores and a longer course 
      of disease had a higher prevalence of NMS. CONCLUSIONS: NMS is also common in PD 
      patients at an early stage. The PIGD group who have more axial injuries and more 
      severe motor symptoms, have a higher risk of NMS burden than PD patients in TD 
      group.
FAU - Zhong, L-L
AU  - Zhong LL
AD  - Department of Neurology, Huai'an First People's Hospital, Nanjing Medical 
      University, Huai'an, Jiangsu, P.R. China. liangyu163mail@163.com.
FAU - Song, Y-Q
AU  - Song YQ
FAU - Cao, H
AU  - Cao H
FAU - Ju, K-J
AU  - Ju KJ
FAU - Yu, L
AU  - Yu L
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Eur Rev Med Pharmacol Sci
JT  - European review for medical and pharmacological sciences
JID - 9717360
SB  - IM
MH  - Female
MH  - Gait
MH  - Humans
MH  - Male
MH  - *Parkinson Disease/diagnosis
MH  - Postural Balance
MH  - Severity of Illness Index
MH  - Surveys and Questionnaires
MH  - Tremor
EDAT- 2017/12/23 06:00
MHDA- 2019/12/20 06:00
CRDT- 2017/12/23 06:00
PHST- 2017/12/23 06:00 [entrez]
PHST- 2017/12/23 06:00 [pubmed]
PHST- 2019/12/20 06:00 [medline]
AID - 14021 [pii]
AID - 10.26355/eurrev_201712_14021 [doi]
PST - ppublish
SO  - Eur Rev Med Pharmacol Sci. 2017 Dec;21(24):5745-5750. doi: 
      10.26355/eurrev_201712_14021.