PMID- 29272791
OWN - NLM
STAT- MEDLINE
DCOM- 20180827
LR  - 20220330
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 228
DP  - 2018 Mar 1
TI  - Disrupted functional connectivity of the amygdala is associated with depressive 
      mood in type 2 diabetes patients.
PG  - 207-215
LID - S0165-0327(17)31493-3 [pii]
LID - 10.1016/j.jad.2017.12.012 [doi]
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) and mood disorders share 
      pathophysiological commonalities in the central nervous system. The purpose of 
      this study was to investigate the alterations in amygdala-based emotional 
      processing circuits in T2DM patients with depressive mood using resting-state 
      functional magnetic resonance imaging (rs-fMRI). METHODS: T2DM patients with 
      depressive mood (n = 25), T2DM patients without depressive mood (n = 28) and 
      matched healthy controls (n = 25) underwent neuropsychological testing and 
      rs-fMRI scanning. A seed-based correlation analysis was conducted to reveal the 
      altered functional connectivity (FC) of the amygdala. The bilateral amygdala FC 
      was compared among the three groups. Pearson correlation analyses were performed 
      in a voxel-wise manner to investigate the relationship between amygdala FC and 
      the clinical characteristics. RESULTS: The depressed T2DM patients exhibited the 
      worst performance on the neuropsychological tests among the three groups. 
      Compared to the non-depressed T2DM patients, the depressed T2DM patients showed 
      decreased amygdala FC in the cingulate cortex, inferior frontal gyrus, fusiform 
      gyrus, and precentral gyrus. Moreover, the amygdala FC in the cingulate cortex 
      was associated with the Self-Rating Depression Scale (SDS) score in the T2DM 
      patients. LIMITATIONS: Cross-sectional design. CONCLUSIONS: The current study 
      revealed the cognitive changes and alterations in the amygdala-cingulate 
      functional disconnections in T2DM patients with depressive mood, which will 
      advance the understanding of the neural mechanisms underlying depression in T2DM 
      patients.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Xia, Wenqing
AU  - Xia W
AD  - Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, 
      No. 68, Changle Road, Nanjing 210006, China.
FAU - Luo, Yong
AU  - Luo Y
AD  - Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, 
      No. 68, Changle Road, Nanjing 210006, China.
FAU - Chen, Yu-Chen
AU  - Chen YC
AD  - Department of Radiology, Nanjing First Hospital, Nanjing Medical University, No. 
      68, Changle Road, Nanjing 210006, China.
FAU - Zhang, Danfeng
AU  - Zhang D
AD  - Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, 
      No. 68, Changle Road, Nanjing 210006, China.
FAU - Bo, Fan
AU  - Bo F
AD  - Department of Radiology, Nanjing First Hospital, Nanjing Medical University, No. 
      68, Changle Road, Nanjing 210006, China.
FAU - Zhou, Peihua
AU  - Zhou P
AD  - Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, 
      No. 68, Changle Road, Nanjing 210006, China.
FAU - Chen, Huiyou
AU  - Chen H
AD  - Department of Radiology, Nanjing First Hospital, Nanjing Medical University, No. 
      68, Changle Road, Nanjing 210006, China.
FAU - Wang, Fang
AU  - Wang F
AD  - Department of Radiology, Nanjing First Hospital, Nanjing Medical University, No. 
      68, Changle Road, Nanjing 210006, China.
FAU - Yin, Xindao
AU  - Yin X
AD  - Department of Radiology, Nanjing First Hospital, Nanjing Medical University, No. 
      68, Changle Road, Nanjing 210006, China. Electronic address: y.163yy@163.com.
FAU - Ma, Jianhua
AU  - Ma J
AD  - Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, 
      No. 68, Changle Road, Nanjing 210006, China. Electronic address: 
      majianhua@china.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171207
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
SB  - IM
MH  - Adult
MH  - Amygdala/diagnostic imaging/*physiopathology
MH  - Brain Mapping
MH  - Cross-Sectional Studies
MH  - Depression/physiopathology
MH  - Diabetes Mellitus, Type 2/*physiopathology
MH  - Emotions/physiology
MH  - Female
MH  - Frontal Lobe/physiopathology
MH  - Gyrus Cinguli/diagnostic imaging/physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Middle Aged
MH  - Mood Disorders/diagnostic imaging/*physiopathology
MH  - Neural Pathways/diagnostic imaging/*physiopathology
MH  - Neuropsychological Tests
MH  - Prefrontal Cortex/physiopathology
MH  - Temporal Lobe/diagnostic imaging/physiopathology
OTO - NOTNLM
OT  - Amygdala
OT  - Depression
OT  - Functional connectivity
OT  - Resting-state fMRI
OT  - Type 2 diabetes mellitus
EDAT- 2017/12/23 06:00
MHDA- 2018/08/28 06:00
CRDT- 2017/12/23 06:00
PHST- 2017/07/20 00:00 [received]
PHST- 2017/11/18 00:00 [revised]
PHST- 2017/12/06 00:00 [accepted]
PHST- 2017/12/23 06:00 [pubmed]
PHST- 2018/08/28 06:00 [medline]
PHST- 2017/12/23 06:00 [entrez]
AID - S0165-0327(17)31493-3 [pii]
AID - 10.1016/j.jad.2017.12.012 [doi]
PST - ppublish
SO  - J Affect Disord. 2018 Mar 1;228:207-215. doi: 10.1016/j.jad.2017.12.012. Epub 
      2017 Dec 7.