PMID- 29272818
OWN - NLM
STAT- MEDLINE
DCOM- 20180831
LR  - 20211204
IS  - 1878-1705 (Electronic)
IS  - 1567-5769 (Linking)
VI  - 55
DP  - 2018 Feb
TI  - Isorhamnetin, the active constituent of a Chinese herb Hippophae rhamnoides L, is 
      a potent suppressor of dendritic-cell maturation and trafficking.
PG  - 216-222
LID - S1567-5769(17)30487-3 [pii]
LID - 10.1016/j.intimp.2017.12.014 [doi]
AB  - Dendritic cells (DCs) have been recognized as major targets of immunosuppressive 
      therapies for their significant roles in connecting innate and adaptive immunity. 
      Isorhamnetin (Iso), one of the most common flavonoid compounds extracted from the 
      Chinese herb Hippophae rhamnoides L, has been proved to have anti-inflammatory, 
      anticarcinogenic, and antioxidant activities in many chronic inflammatory 
      conditions, but the effects of Iso on DCs have rarely been reported before. Here 
      we investigated the functions and the mechanisms of Iso on bone marrow-derived 
      DCs (BMDCs) including maturation, phagocytosis, and trafficking. Our data showed 
      that Iso effectively inhibited the maturation of lipopolysaccharide (LPS)-treated 
      BMDCs by down regulation of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, 
      IL-1beta and IL-12p70, up regulation of IL-10, and depression of costimulatory 
      molecules CD40, CD80, and CD86, while had no effects on phagocytosis. 
      Furthermore, Iso inhibited the migration of LPS-treated BMDCs, which may be due 
      to its inhibition on chemokine receptor 7 (CCR7) expression. These findings 
      strongly suggest that Iso is a potent immunosuppressive agent by inhibiting DC 
      activation and trafficking, and may be used to prevent or treat chronic 
      inflammation, autoimmune diseases, and graft rejections.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Shi, Hui
AU  - Shi H
AD  - Department of Rheumatology and Immunology, The Third Affiliated Hospital of 
      Southern Medical University, NO.183, Zhongshan Avenue West, Tianhe District, 
      Guangzhou, Guangdong 510630, China; Department of Rheumatology and Immunology, 
      The Third Affiliated Hospital of Inner Mongolia Medical University (Inner 
      Mongolia BaoGang Hospital), NO.20, Shaoxian Road, Kun District, Baotou, Inner 
      Mongolia 014010, China.
FAU - He, Juan
AU  - He J
AD  - Department of Rheumatology and Immunology, The Third Affiliated Hospital of 
      Southern Medical University, NO.183, Zhongshan Avenue West, Tianhe District, 
      Guangzhou, Guangdong 510630, China.
FAU - Li, Xing
AU  - Li X
AD  - Department of Rheumatology and Immunology, The Third Affiliated Hospital of 
      Southern Medical University, NO.183, Zhongshan Avenue West, Tianhe District, 
      Guangzhou, Guangdong 510630, China.
FAU - Han, Jiaochan
AU  - Han J
AD  - Department of Rheumatology and Immunology, The Third Affiliated Hospital of 
      Southern Medical University, NO.183, Zhongshan Avenue West, Tianhe District, 
      Guangzhou, Guangdong 510630, China.
FAU - Wu, Riga
AU  - Wu R
AD  - Department of Radiology, The Third Affiliated Hospital of Inner Mongolia Medical 
      University (Inner Mongolia BaoGang Hospital), NO.20, Shaoxian Road, Kun District, 
      Baotou, Inner Mongolia 014010,China.
FAU - Wang, Dantong
AU  - Wang D
AD  - Department of Rheumatology and Immunology, The Third Affiliated Hospital of Inner 
      Mongolia Medical University (Inner Mongolia BaoGang Hospital), NO.20, Shaoxian 
      Road, Kun District, Baotou, Inner Mongolia 014010, China.
FAU - Yang, Fangyuan
AU  - Yang F
AD  - Department of Rheumatology and Immunology, The Third Affiliated Hospital of 
      Southern Medical University, NO.183, Zhongshan Avenue West, Tianhe District, 
      Guangzhou, Guangdong 510630, China.
FAU - Sun, Erwei
AU  - Sun E
AD  - Department of Rheumatology and Immunology, The Third Affiliated Hospital of 
      Southern Medical University, NO.183, Zhongshan Avenue West, Tianhe District, 
      Guangzhou, Guangdong 510630, China. Electronic address: sunew@smu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20171222
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 (CD40 Antigens)
RN  - 0 (Cytokines)
RN  - 0 (Immunologic Factors)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Lipopolysaccharides)
RN  - 07X3IB4R4Z (3-methylquercetin)
RN  - 9IKM0I5T1E (Quercetin)
SB  - IM
MH  - Animals
MH  - Bone Marrow Cells/physiology
MH  - CD40 Antigens/metabolism
MH  - Cell Differentiation
MH  - Cell Movement
MH  - Cells, Cultured
MH  - Cytokines/metabolism
MH  - Dendritic Cells/*physiology
MH  - Hippophae/immunology
MH  - Immunologic Factors/*therapeutic use
MH  - Immunosuppression Therapy
MH  - Inflammation Mediators/metabolism
MH  - Lipopolysaccharides/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Phagocytosis
MH  - Quercetin/*analogs & derivatives/therapeutic use
OTO - NOTNLM
OT  - Dendritic cells
OT  - Isorhamnetin
OT  - Maturation
OT  - Trafficking
EDAT- 2017/12/23 06:00
MHDA- 2018/09/01 06:00
CRDT- 2017/12/23 06:00
PHST- 2017/07/19 00:00 [received]
PHST- 2017/12/12 00:00 [revised]
PHST- 2017/12/12 00:00 [accepted]
PHST- 2017/12/23 06:00 [pubmed]
PHST- 2018/09/01 06:00 [medline]
PHST- 2017/12/23 06:00 [entrez]
AID - S1567-5769(17)30487-3 [pii]
AID - 10.1016/j.intimp.2017.12.014 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2018 Feb;55:216-222. doi: 10.1016/j.intimp.2017.12.014. Epub 
      2017 Dec 22.