PMID- 29272887
OWN - NLM
STAT- MEDLINE
DCOM- 20180716
LR  - 20220316
IS  - 1943-7722 (Electronic)
IS  - 0002-9173 (Print)
IS  - 0002-9173 (Linking)
VI  - 149
IP  - 1
DP  - 2017 Dec 20
TI  - The 11q-Gain/Loss Aberration Occurs Recurrently in MYC-Negative Burkitt-like 
      Lymphoma With 11q Aberration, as Well as MYC-Positive Burkitt Lymphoma and 
      MYC-Positive High-Grade B-Cell Lymphoma, NOS.
PG  - 17-28
LID - 10.1093/ajcp/aqx139 [doi]
AB  - OBJECTIVES: The latest revision of lymphoma's World Health Organization 
      classification describes the new provisional entity "Burkitt-like lymphoma with 
      11q aberration" (BLL, 11q) as lacking MYC rearrangement, but harboring the 
      specific11q-gain/loss aberration. We report genetic characteristics of 11 
      lymphoma cases with this aberration. METHODS: Classical cytogenetics, 
      fluorescence in situ hybridization (FISH), and single nucleotide 
      polymorphism/array comparative genomic hybridization. RESULTS: The 11q 
      aberrations were described as duplication, inversion, and deletion. Array 
      comparative genomic hybridization showed two types of duplication: bigger than 50 
      megabase pairs (Mbp) and smaller than 20 Mbp, which were associated with bulky 
      tumor larger than 20 cm and amplification of the 11q23.3 region, including KMT2A. 
      Six cases revealed a normal FISH status of MYC and were diagnosed as BLL,11q. 
      Five cases showed MYC rearrangement and were diagnosed as Burkitt lymphoma (BL) 
      or high-grade B-cell lymphoma, not otherwise specified (HGBL, NOS). CONCLUSIONS: 
      The 11q-gain/loss is not specific for BLL, 11q, but occurs recurrently in 
      MYC-positive BL and MYC-positive HGBL.
CI  - (c) American Society for Clinical Pathology, 2017.
FAU - Grygalewicz, Beata
AU  - Grygalewicz B
AD  - Cytogenetic Laboratory, Maria Sklodowska-Curie Institute Oncology Center, Warsaw, 
      Poland.
FAU - Woroniecka, Renata
AU  - Woroniecka R
AD  - Cytogenetic Laboratory, Maria Sklodowska-Curie Institute Oncology Center, Warsaw, 
      Poland.
FAU - Rymkiewicz, Grzegorz
AU  - Rymkiewicz G
AD  - Cytogenetic Laboratory, Maria Sklodowska-Curie Institute Oncology Center, Warsaw, 
      Poland.
AD  - Flow Cytometry Laboratory, Pathology and Laboratory Diagnostics Department, Maria 
      Sklodowska-Curie Institute Oncology Center, Warsaw, Poland.
FAU - Rygier, Jolanta
AU  - Rygier J
AD  - Cytogenetic Laboratory, Maria Sklodowska-Curie Institute Oncology Center, Warsaw, 
      Poland.
FAU - Borkowska, Klaudia
AU  - Borkowska K
AD  - Cytogenetic Laboratory, Maria Sklodowska-Curie Institute Oncology Center, Warsaw, 
      Poland.
FAU - Kotyl, Aleksandra
AU  - Kotyl A
AD  - Cytogenetic Laboratory, Maria Sklodowska-Curie Institute Oncology Center, Warsaw, 
      Poland.
FAU - Blachnio, Katarzyna
AU  - Blachnio K
AD  - Flow Cytometry Laboratory, Pathology and Laboratory Diagnostics Department, Maria 
      Sklodowska-Curie Institute Oncology Center, Warsaw, Poland.
FAU - Bystydzienski, Zbigniew
AU  - Bystydzienski Z
AD  - Flow Cytometry Laboratory, Pathology and Laboratory Diagnostics Department, Maria 
      Sklodowska-Curie Institute Oncology Center, Warsaw, Poland.
FAU - Nowakowska, Beata
AU  - Nowakowska B
AD  - Department of Medical Genetics, Mother and Child Institute, Warsaw, Poland.
FAU - Pienkowska-Grela, Barbara
AU  - Pienkowska-Grela B
AD  - Cytogenetic Laboratory, Maria Sklodowska-Curie Institute Oncology Center, Warsaw, 
      Poland.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
RN  - 0 (MYC protein, human)
RN  - 0 (Proto-Oncogene Proteins c-myc)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Burkitt Lymphoma/classification/diagnosis/*genetics/pathology
MH  - Chromosomes, Human, Pair 11/*genetics
MH  - Comparative Genomic Hybridization
MH  - Gene Rearrangement, B-Lymphocyte/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, B-Cell/classification/diagnosis/*genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Proto-Oncogene Proteins c-myc/*genetics
MH  - Young Adult
PMC - PMC5848380
OTO - NOTNLM
OT  - 11q-gain/loss
OT  - Burkitt-like lymphoma with 11q aberration
OT  - High-grade B-cell lymphoma
OT  - KMT2A
OT  - MYC
EDAT- 2017/12/23 06:00
MHDA- 2018/07/17 06:00
PMCR- 2017/12/20
CRDT- 2017/12/23 06:00
PHST- 2017/12/23 06:00 [entrez]
PHST- 2017/12/23 06:00 [pubmed]
PHST- 2018/07/17 06:00 [medline]
PHST- 2017/12/20 00:00 [pmc-release]
AID - 4768236 [pii]
AID - aqx139 [pii]
AID - 10.1093/ajcp/aqx139 [doi]
PST - ppublish
SO  - Am J Clin Pathol. 2017 Dec 20;149(1):17-28. doi: 10.1093/ajcp/aqx139.