PMID- 29273135
OWN - NLM
STAT- MEDLINE
DCOM- 20190111
LR  - 20190131
IS  - 1534-4436 (Electronic)
IS  - 1081-1206 (Linking)
VI  - 120
IP  - 1
DP  - 2018 Jan
TI  - Complex relationships between vitamin D and allergic sensitization among Puerto 
      Rican 2-year-old children.
PG  - 84-89
LID - S1081-1206(17)31194-8 [pii]
LID - 10.1016/j.anai.2017.10.027 [doi]
AB  - BACKGROUND: In the United States, Puerto Ricans have a higher prevalence of 
      asthma than other Latino ethnicities. Low vitamin D levels for children living in 
      northern climates could be a factor. OBJECTIVE: To assess serum 25-hydroxyvitamin 
      D [25(OH)D] distributions (a marker of vitamin D) and associations among vitamin 
      D, allergic sensitization, early wheeze, and home/demographic factors. METHODS: 
      Puerto Rican infants born in New York City, with a maternal history of atopy, 
      were enrolled in a birth cohort. Blood was collected at age 2 years (n = 154; 82 
      males and 72 females). Serum 25(OH)D and immunoglobulin E (IgE) (indoor 
      allergen-specific and total) were determined using immunoassays. Home/demographic 
      characteristics and respiratory symptoms were assessed by questionnaire. RESULTS: 
      The median concentration of 25(OH)D was 22.6 ng/mL; 32% were at risk of 
      deficiency or inadequacy (<12 or 12-19 ng/mL). Serum 25(OH)D levels were lower in 
      the heating (a surrogate for less sun exposure in colder months) compared with 
      nonheating (26.1 vs 22.7 ng/mL, P = .02) season, but were not associated with 
      allergen-specific IgE levels or with level of acculturation (measured by maternal 
      birthplace). However, low 25(OH)D levels (below median) were associated with high 
      total IgE >100 IU/mL (P = .01). Also, 25(OH)D concentrations differed between 
      children who attended daycare and those who did not (21.8 vs 24.5 ng/mL; t test, 
      P = .02). Serum 25(OH)D was not associated with wheeze or asthma by 2 years of 
      age (P = .43). CONCLUSION: Vitamin D deficiency, possibly linked with allergic 
      pathways, may partially explain the trajectory for disproportionate asthma burden 
      among Puerto Ricans, especially those born and raised in colder climates.
CI  - Copyright (c) 2017 American College of Allergy, Asthma & Immunology. All rights 
      reserved.
FAU - Kannan, Srimathi
AU  - Kannan S
AD  - Department of Nutrition, School of Public Health and Health Sciences, University 
      of Massachusetts, Amherst, Massachusetts; Department of Food and Nutrition, 
      Southern Illinois University, Carbondale, Illinois. Electronic address: 
      srimathik@gmail.com.
FAU - Perzanowski, Matthew S
AU  - Perzanowski MS
AD  - Department of Environmental Health Sciences, Mailman School of Public Health, 
      Columbia University, New York, New York.
FAU - Ganguri, Harish B
AU  - Ganguri HB
AD  - Department of Computer Science, Southern Illinois University, Carbondale, 
      Illinois; Kronsys, Inc, Raleigh, North Carolina.
FAU - Acevedo-Garcia, Dolores
AU  - Acevedo-Garcia D
AD  - The Heller School for Social Policy and Management, Brandeis University, Waltham, 
      Massachusetts.
FAU - Acosta, Luis M
AU  - Acosta LM
AD  - Department of Environmental Health Sciences, Mailman School of Public Health, 
      Columbia University, New York, New York.
FAU - Spatcher, Molly
AU  - Spatcher M
AD  - Department of Nutrition, School of Public Health and Health Sciences, University 
      of Massachusetts, Amherst, Massachusetts; Eye and Lasik Center, Greenfield, 
      Massachusetts.
FAU - Divjan, Adnan
AU  - Divjan A
AD  - Department of Environmental Health Sciences, Mailman School of Public Health, 
      Columbia University, New York, New York.
FAU - Chew, Ginger L
AU  - Chew GL
AD  - Department of Environmental Health Sciences, Mailman School of Public Health, 
      Columbia University, New York, New York.
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ann Allergy Asthma Immunol
JT  - Annals of allergy, asthma & immunology : official publication of the American 
      College of Allergy, Asthma, & Immunology
JID - 9503580
RN  - 1406-16-2 (Vitamin D)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - A288AR3C9H (25-hydroxyvitamin D)
SB  - IM
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Follow-Up Studies
MH  - Humans
MH  - Hypersensitivity/*epidemiology
MH  - Immunoglobulin E/blood
MH  - Infant
MH  - Infant, Newborn
MH  - New York City/epidemiology
MH  - Puerto Rico/ethnology
MH  - Respiratory Sounds
MH  - Risk
MH  - Seasons
MH  - Vitamin D/*analogs & derivatives/blood
MH  - Vitamin D Deficiency/*epidemiology
EDAT- 2017/12/24 06:00
MHDA- 2019/01/12 06:00
CRDT- 2017/12/24 06:00
PHST- 2017/08/04 00:00 [received]
PHST- 2017/09/25 00:00 [revised]
PHST- 2017/10/18 00:00 [accepted]
PHST- 2017/12/24 06:00 [entrez]
PHST- 2017/12/24 06:00 [pubmed]
PHST- 2019/01/12 06:00 [medline]
AID - S1081-1206(17)31194-8 [pii]
AID - 10.1016/j.anai.2017.10.027 [doi]
PST - ppublish
SO  - Ann Allergy Asthma Immunol. 2018 Jan;120(1):84-89. doi: 
      10.1016/j.anai.2017.10.027.