PMID- 29274088
OWN - NLM
STAT- MEDLINE
DCOM- 20180822
LR  - 20180822
IS  - 1439-0507 (Electronic)
IS  - 0933-7407 (Linking)
VI  - 61
IP  - 4
DP  - 2018 Apr
TI  - Autopsy and biopsy study of paracoccidioidomycosis and 
      neuroparacoccidioidomycosis with and without HIV co-infection.
PG  - 237-244
LID - 10.1111/myc.12737 [doi]
AB  - Paracoccidioidomycosis (PCM) is a systemic mycosis prevalent among 
      immunocompetent patients in Latin America. This study aimed to describe the 
      frequency, demographics and clinical characteristics of central nervous system 
      PCM (NPCM) and PCM in an endemic region, and the impact of human 
      immunosuppression virus (HIV) co-infection. This was a retrospective study of 
      autopsy and biopsy reports from the Medical Pathology Section of the Hospital de 
      Clinicas, UFPR, Curitiba, Southern Brazil, between 1951 and 2014. PCM was present 
      in 0.1% of 378,323 cases examined, with 5.7% being NPCM. Infection was prevalent 
      in working-age men, agricultural workers and rural residents. Numbers of HIV 
      autopsy cases increased over time, while those of PCM cases decreased. Prevalence 
      of co-infection of HIV/PCM and HIV/NPCM was 1.6%, and 0.4%, respectively. 
      Adrenals were affected more frequently in the NPCM group compared with the PCM 
      group. Mortality was higher on NPCM group. The clinical course of PCM in HIV 
      patients resembles an acute/sub-acute infection. Association of NPCM and HIV is 
      rare, while diagnosis of NPCM is difficult, it should be considered a 
      differential diagnosis in HIV patients who live in, or have visited, endemic 
      areas and present with neurological symptoms.
CI  - (c) 2017 Blackwell Verlag GmbH.
FAU - de Almeida, Sergio Monteiro
AU  - de Almeida SM
AUID- ORCID: 0000-0001-5690-105X
AD  - Medical Patology Departament, Medicine School, Universidade Federal do Parana, 
      Curitiba, Brazil.
AD  - Virology Laboratory, Hospital de Clinicas, Universidade Federal do Parana, 
      Curitiba, Brazil.
AD  - Faculdades Pequeno Principe, Curitiba, Brazil.
AD  - Instituto de Pesquisa Pele Pequeno Principe, Curitiba, Brazil.
FAU - Roza, Thiago Henrique
AU  - Roza TH
AD  - Medical Patology Departament, Medicine School, Universidade Federal do Parana, 
      Curitiba, Brazil.
FAU - Salvador, Gabriel L O
AU  - Salvador GLO
AD  - Medical Patology Departament, Medicine School, Universidade Federal do Parana, 
      Curitiba, Brazil.
FAU - Izycki, Luis Felipe
AU  - Izycki LF
AD  - Medical Patology Departament, Medicine School, Universidade Federal do Parana, 
      Curitiba, Brazil.
FAU - Locatelli, Giuliana
AU  - Locatelli G
AD  - Medical Patology Departament, Medicine School, Universidade Federal do Parana, 
      Curitiba, Brazil.
FAU - Santos, Isaias Dos
AU  - Santos ID
AD  - Medical Patology Departament, Medicine School, Universidade Federal do Parana, 
      Curitiba, Brazil.
FAU - Aragao, Afonso
AU  - Aragao A
AD  - Medical Patology Departament, Medicine School, Universidade Federal do Parana, 
      Curitiba, Brazil.
FAU - Torres, Luis Fernando Bleggi
AU  - Torres LFB
AD  - Medical Patology Departament, Medicine School, Universidade Federal do Parana, 
      Curitiba, Brazil.
AD  - Faculdades Pequeno Principe, Curitiba, Brazil.
AD  - Instituto de Pesquisa Pele Pequeno Principe, Curitiba, Brazil.
FAU - de Noronha, Lucia Helena
AU  - de Noronha LH
AD  - Medical Patology Departament, Medicine School, Universidade Federal do Parana, 
      Curitiba, Brazil.
AD  - Laboratorio de Patologia Experimental, Escola de Medicina- Pontificia 
      Universidade Catolica do Parana, Curitiba, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20180123
PL  - Germany
TA  - Mycoses
JT  - Mycoses
JID - 8805008
SB  - IM
MH  - Adult
MH  - Autopsy
MH  - Biopsy
MH  - Brazil/epidemiology
MH  - Central Nervous System Fungal Infections/epidemiology/mortality/*pathology
MH  - Coinfection/epidemiology/*pathology
MH  - Female
MH  - HIV Infections/*complications
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Occupational Exposure
MH  - Paracoccidioidomycosis/epidemiology/mortality/*pathology
MH  - Prevalence
MH  - Retrospective Studies
MH  - Survival Analysis
OTO - NOTNLM
OT  - HIV
OT  - Paracoccidioides brasiliensis
OT  - autopsy
OT  - central nervous system
OT  - necropsy
OT  - paracoccidioidomycosis
EDAT- 2017/12/24 06:00
MHDA- 2018/08/23 06:00
CRDT- 2017/12/24 06:00
PHST- 2017/11/16 00:00 [received]
PHST- 2017/12/13 00:00 [revised]
PHST- 2017/12/16 00:00 [accepted]
PHST- 2017/12/24 06:00 [pubmed]
PHST- 2018/08/23 06:00 [medline]
PHST- 2017/12/24 06:00 [entrez]
AID - 10.1111/myc.12737 [doi]
PST - ppublish
SO  - Mycoses. 2018 Apr;61(4):237-244. doi: 10.1111/myc.12737. Epub 2018 Jan 23.