PMID- 29274843
OWN - NLM
STAT- MEDLINE
DCOM- 20180816
LR  - 20181202
IS  - 1532-2785 (Electronic)
IS  - 0143-4179 (Linking)
VI  - 67
DP  - 2018 Feb
TI  - Oxaliplatin-induced changes in expression of transient receptor potential 
      channels in the dorsal root ganglion as a neuropathic mechanism for cold 
      hypersensitivity.
PG  - 95-101
LID - S0143-4179(17)30226-3 [pii]
LID - 10.1016/j.npep.2017.12.002 [doi]
AB  - Transient receptor potential (TRP) receptors are involved in the development of 
      chemotherapy-induced peripheral neuropathic pain, which is a common side effect 
      of selected chemotherapeutic agents such as oxaliplatin. However, the precise 
      contribution of TRPs to this condition remains unknown. Cold hypersensitivity is 
      the hallmark of oxaliplatin-induced neuropathy, so we used a preclinical model of 
      oxaliplatin-induced cold hypersensitivity in rats to determine the effects of 
      oxaliplatin on TRP channels. To this end, immunohistochemistry was used to 
      examine TRP vanilloid 1 (TRPV1), TRP ankyrin 1 (TRPA1), and TRP melastatin 8 
      (TRPM8) expression in the rat dorsal root ganglion (DRG) after 4days of 
      oxaliplatin treatment. Behavioral assessment using the acetone spray test showed 
      that oxaliplatin significantly increased acute cold hypersensitivity after 4days 
      of treatment. Double-staining immunohistochemistry showed that 4days after 
      oxaliplatin treatment, there was increased co-expression of TRPA1 and TRPV1 in 
      isolectin B4-positive small-sized DRG neurons, as well as a significant increase 
      in the co-localization of TRPM8 and neurofilament 200 in medium-sized DRG 
      neurons. In addition, in situ hybridization revealed that TRPV1 protein was 
      co-expressed with TRPA1 mRNA on day 4 after oxaliplatin administration. Thus, at 
      an early stage following oxaliplatin treatment there is an increased expression 
      of TRPA1 and TRPV1 in small-sized DRG neurons and of TRPM8 in medium-sized DRG 
      neurons. Collectively, these changes may contribute to the development of 
      oxaliplatin-induced peripheral neuropathic pain.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Chukyo, Akiko
AU  - Chukyo A
AD  - Department of Pharmacy and Neurology, Juntendo University Hospital, 3-1-3 Hongo, 
      Bunkyo, Tokyo 113-8431, Japan.
FAU - Chiba, Terumasa
AU  - Chiba T
AD  - Faculty of Pharmaceutical Sciences, Nihon Pharmaceutical University, 10281 
      Komuro, Ina-machi, Kitaadachi-gun, Saitama 362-0806, Japan.
FAU - Kambe, Toshie
AU  - Kambe T
AD  - Department of Pharmacology, Showa Pharmaceutical University, Machida, Tokyo 
      194-8543, Japan.
FAU - Yamamoto, Ken
AU  - Yamamoto K
AD  - Department of Education and Research Center for Clinical Pharmacy, Showa 
      Pharmaceutical University, Machida, Tokyo 194-8543, Japan.
FAU - Kawakami, Kazuyoshi
AU  - Kawakami K
AD  - Department of Pharmacy, Cancer Institute Hospital, 3-10-6 Ariake, Koto-Ku, Tokyo 
      135-8550, Japan.
FAU - Taguchi, Kyoji
AU  - Taguchi K
AD  - Department of Medicinal Pharmacology, Showa Pharmaceutical University, Machida, 
      Tokyo 194-8543, Japan.
FAU - Abe, Kenji
AU  - Abe K
AD  - Faculty of Pharmaceutical Sciences, Nihon Pharmaceutical University, 10281 
      Komuro, Ina-machi, Kitaadachi-gun, Saitama 362-0806, Japan. Electronic address: 
      k-abe@nichiyaku.ac.jp.
LA  - eng
PT  - Journal Article
DEP - 20171215
PL  - Netherlands
TA  - Neuropeptides
JT  - Neuropeptides
JID - 8103156
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Organoplatinum Compounds)
RN  - 0 (TRPV Cation Channels)
RN  - 0 (TRPV1 receptor)
RN  - 0 (Transient Receptor Potential Channels)
RN  - 04ZR38536J (Oxaliplatin)
RN  - Cold Hypersensitivity
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/*pharmacology
MH  - Cold Temperature
MH  - Cryopyrin-Associated Periodic Syndromes/physiopathology
MH  - Ganglia, Spinal/*drug effects/metabolism
MH  - Hyperalgesia/chemically induced
MH  - Male
MH  - Neuralgia/chemically induced
MH  - Neurons/drug effects/metabolism
MH  - Organoplatinum Compounds/*pharmacology
MH  - Oxaliplatin
MH  - Rats, Wistar
MH  - TRPV Cation Channels/drug effects
MH  - Transient Receptor Potential Channels/*drug effects/metabolism
OTO - NOTNLM
OT  - Acute cold hypersensitivity
OT  - Dorsal root ganglion
OT  - Oxaliplatin
OT  - Transient receptor potential channels
EDAT- 2017/12/25 06:00
MHDA- 2018/08/17 06:00
CRDT- 2017/12/25 06:00
PHST- 2017/08/15 00:00 [received]
PHST- 2017/11/24 00:00 [revised]
PHST- 2017/12/09 00:00 [accepted]
PHST- 2017/12/25 06:00 [pubmed]
PHST- 2018/08/17 06:00 [medline]
PHST- 2017/12/25 06:00 [entrez]
AID - S0143-4179(17)30226-3 [pii]
AID - 10.1016/j.npep.2017.12.002 [doi]
PST - ppublish
SO  - Neuropeptides. 2018 Feb;67:95-101. doi: 10.1016/j.npep.2017.12.002. Epub 2017 Dec 
      15.