PMID- 29275426 OWN - NLM STAT- MEDLINE DCOM- 20180702 LR - 20181202 IS - 1434-4726 (Electronic) IS - 0937-4477 (Linking) VI - 275 IP - 2 DP - 2018 Feb TI - Platelet-to-lymphocyte ratio predicts long-term survival in laryngeal cancer. PG - 553-559 LID - 10.1007/s00405-017-4849-4 [doi] AB - OBJECTIVES: Although the survival rate of laryngeal cancer is relatively high, some patients with laryngeal squamous cell carcinoma (LSCC) show the least benefit from laryngectomy, owing to few determining diagnostic tools. We aimed to identify high-risk patients according to a preoperatively determined signature of the platelet-to-lymphocyte ratio (PLR) of > 193.55, as an indicator of poor treatment outcome in LSCC patients. METHODS: We retrospectively evaluated 899 patients who underwent laryngectomy for LSCC. The patients were stratified by PLR into three subgroups: low ( 119.55 and 193.55). Kaplan-Meier curves were plotted to compare the intergroup cancer-specific survival (CSS). RESULTS: Patients with high PLR had significantly worse survival outcomes (5-year CSS, low vs. moderate vs. high: 75.3 vs. 68.4 vs. 53.9%; 10-year CSS, low vs. moderate vs. high: 65.0 vs. 56.0 vs. 38.6%, P < 0.001). Patients with PLR > 193.55 represented malnutrition and more advanced cancer stage.. CONCLUSION: Patients with PLR > 193.55 experience poor outcomes and represent malnutrition, more advanced cancer stage. FAU - Mao, Yize AU - Mao Y AD - Department of Hepatobiliary Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, No. 651 Dongfeng Road East, Guangzhou, 510060, China. FAU - Fu, Yan AU - Fu Y AD - Department of Head and Neck Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, No. 651 Dongfeng Road East, Guangzhou, 510060, China. FAU - Gao, Yunfei AU - Gao Y AD - Department of Otolaryngology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai City, 519020, Guangdong Province, China. FAU - Yang, Ankui AU - Yang A AD - Department of Head and Neck Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, No. 651 Dongfeng Road East, Guangzhou, 510060, China. FAU - Zhang, Quan AU - Zhang Q AUID- ORCID: 0000-0003-4908-1190 AD - Department of Head and Neck Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, No. 651 Dongfeng Road East, Guangzhou, 510060, China. zhangquansysucc@163.com. LA - eng PT - Journal Article DEP - 20171223 PL - Germany TA - Eur Arch Otorhinolaryngol JT - European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery JID - 9002937 SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Carcinoma, Squamous Cell/*blood/mortality/surgery MH - Female MH - Humans MH - Kaplan-Meier Estimate MH - Laryngeal Neoplasms/*blood/mortality/surgery MH - *Laryngectomy MH - *Lymphocyte Count MH - Male MH - Middle Aged MH - Neoplasm Staging MH - *Platelet Count MH - Prognosis MH - Retrospective Studies MH - Survival Rate MH - Treatment Outcome MH - Young Adult OTO - NOTNLM OT - Cancer-specific survival OT - Laryngeal squamous cell carcinoma OT - Platelet-to-lymphocyte ratio EDAT- 2017/12/25 06:00 MHDA- 2018/07/03 06:00 CRDT- 2017/12/25 06:00 PHST- 2017/08/01 00:00 [received] PHST- 2017/12/15 00:00 [accepted] PHST- 2017/12/25 06:00 [pubmed] PHST- 2018/07/03 06:00 [medline] PHST- 2017/12/25 06:00 [entrez] AID - 10.1007/s00405-017-4849-4 [pii] AID - 10.1007/s00405-017-4849-4 [doi] PST - ppublish SO - Eur Arch Otorhinolaryngol. 2018 Feb;275(2):553-559. doi: 10.1007/s00405-017-4849-4. Epub 2017 Dec 23.