PMID- 29275589
OWN - NLM
STAT- MEDLINE
DCOM- 20180629
LR  - 20181202
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 97
IP  - 45
DP  - 2017 Dec 5
TI  - [Characteristics of cognitive impairment and the resting state functional MRI in 
      patients with leukoaraiosis].
PG  - 3529-3533
LID - 10.3760/cma.j.issn.0376-2491.2017.45.003 [doi]
AB  - Objective: To investigate the features of cognitive impairment and potential 
      physiopathologic mechanism using neuropsychological assessment and resting state 
      functional magnetic resonance imaging (rs-fMRI) in patients with leukoaraiosis 
      (LA). Methods: A total of 13 patients with LA (LA group) and 13 healthy controls 
      (NC group) from Shanxi Provincial People's Hospital between January and June 2016 
      were recruited. The two groups were matched for age, sex, education, and vascular 
      risk factors. All the subjects underwent neuropsychological assessment and the 
      scan of rs-fMRI. The neuropsychological scores and the brain areas had 
      significant differences of cerebral spontaneous activity in resting state of the 
      two groups were compared, and the relationship between the scores and the 
      amplitude of low frequency fluctuation (ALFF) were evaluated in these areas. 
      Results: LA group was associated with comprehensive cognitive impairment, 
      including minimum mental state examination (MMSE) (LA group: 23.3+/-10.7 vs NC 
      group: 29.7+/-0.6), montreal cognitive assessment (MoCA) (22.7+/-10.7 vs 29.5+/-0.7), 
      digit span test (DS) forwards (6.5+/-3.2 vs 8.7+/-1.1) and backwards (4.2+/-2.2 vs 
      6.2+/-0.9), trail making test (TMT) part A (168+/-136 vs 47+/-10), immediate memory 
      (6.1+/-3.5 vs 11.0+/-2.2) and delayed memory (4.7+/-2.8 vs 11.0+/-2.4) of auditory verbal 
      learning test (AVLT), Stroop B (60+/-34 vs 32+/-7) and C (127+/-72 vs 48+/-12), verbal 
      similarity test (16.5+/-8.1 vs 23.1+/-2.5) (all P<0.05). Compared with the NC group, 
      patients with LA showed decreased ALFF in areas of the right posterior cingulate 
      cortex (PCC), precuneus_R, cuneus, postcentral_R, precentral_R, calcarine_R (all 
      P<0.05). After adjustment for the influences of age, sex and education, the 
      correlation analysis showed that right PCC, precuneus_R, cuneus, postcentral_R, 
      etc, were closely related with cognitive impairment. Conclusions: Patients with 
      LA exhibits significant cognitive impairment, such as executive function, memory, 
      attention and information processing speed. And cognitive impairment of LA is 
      related to abnormal cerebral spontaneous activity, especially in areas of right 
      PCC, precuneus_R, cuneus, etc.
FAU - Li, Q
AU  - Li Q
AD  - Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan 030012, 
      China.
FAU - Zhao, L Q
AU  - Zhao LQ
FAU - Hu, F Y
AU  - Hu FY
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
SB  - IM
MH  - Brain/*pathology
MH  - Cognitive Dysfunction/*etiology
MH  - Female
MH  - Humans
MH  - Leukoaraiosis/*complications
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Neuropsychological Tests
OTO - NOTNLM
OT  - Amplitude of low frequency fluctuation
OT  - Cognitive impairment
OT  - Leukoaraiosis
OT  - Magnetic resonance imaging
EDAT- 2017/12/26 06:00
MHDA- 2018/06/30 06:00
CRDT- 2017/12/26 06:00
PHST- 2017/12/26 06:00 [entrez]
PHST- 2017/12/26 06:00 [pubmed]
PHST- 2018/06/30 06:00 [medline]
AID - 10.3760/cma.j.issn.0376-2491.2017.45.003 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2017 Dec 5;97(45):3529-3533. doi: 
      10.3760/cma.j.issn.0376-2491.2017.45.003.