PMID- 29275796
OWN - NLM
STAT- MEDLINE
DCOM- 20180604
LR  - 20180604
IS  - 2093-8152 (Electronic)
IS  - 2005-2901 (Linking)
VI  - 10
IP  - 6
DP  - 2017 Dec
TI  - Antidepressant Effects of Pharmacopuncture on Behavior and Brain-Derived 
      Neurotrophic Factor (BDNF) Expression in Chronic Stress Model of Mice.
PG  - 402-408
LID - S2005-2901(17)30113-9 [pii]
LID - 10.1016/j.jams.2017.08.007 [doi]
AB  - OBJECTIVES: The present study aimed to investigate the antidepressant effect of 
      the traditional Korean medical pharmacopuncture, Liver Qi Depression (HJ11), in a 
      mouse model of depression induced by exposure to chronic immobilization stress 
      (CIS). METHODS: Mice were subjected to 2 hours of immobilization stress daily for 
      14 days. They were also injected with distilled water (DW) (CIS + DW) or HJ11 at 
      the acupoints HT7, SP6, and GV20 (CIS + HJ11) an hour before stress. The positive 
      control group (CIS + paroxetine) was intraperitoneally injected with paroxetine 
      (10 mg/kg, 14 days). The tail suspension test and the forced swimming test were 
      performed to assess depression-like behaviors. Western blotting was also 
      conducted to seek the change in brain. RESULTS: CIS + DW mice showed 
      significantly longer immobile times in the tail suspension test and forced 
      swimming test than sham mice that did not go through daily restraint. Immobility 
      of CIS + HJ11 and that of CIS + paroxetine mice was significantly decreased 
      compared with immobility of CIS + DW mice. Immunoblotting showed that HJ11 
      increased the expression of brain-derived neurotrophic factor both in the 
      hippocampus and the amygdala. CONCLUSION: HJ11 improves depressive-like behaviors 
      in the stress-induced mouse model of depression, and the results indicate that 
      the neuroprotective effect of HJ11, identified by brain-derived neurotrophic 
      factor expression, may play a critical role in its antidepressant effect.
CI  - Copyright (c) 2017. Published by Elsevier B.V.
FAU - Kim, Yunna
AU  - Kim Y
AD  - Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, 
      Seoul, South Korea; College of Korean Medicine, Kyung Hee University, Seoul, 
      South Korea; Research Group of Neuroscience, East-West Medical Research 
      Institute, WHO Collaborating Center, Kyung Hee University, Seoul, South Korea.
FAU - Lee, Hwa-Young
AU  - Lee HY
AD  - College of Korean Medicine, Kyung Hee University, Seoul, South Korea; Research 
      Group of Neuroscience, East-West Medical Research Institute, WHO Collaborating 
      Center, Kyung Hee University, Seoul, South Korea.
FAU - Cho, Seung-Hun
AU  - Cho SH
AD  - College of Korean Medicine, Kyung Hee University, Seoul, South Korea; Research 
      Group of Neuroscience, East-West Medical Research Institute, WHO Collaborating 
      Center, Kyung Hee University, Seoul, South Korea. Electronic address: 
      chosh@khmc.or.kr.
LA  - eng
PT  - Journal Article
DEP - 20170830
PL  - Korea (South)
TA  - J Acupunct Meridian Stud
JT  - Journal of acupuncture and meridian studies
JID - 101490763
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - *Acupuncture Points
MH  - Animals
MH  - Antidepressive Agents/*administration & dosage
MH  - Behavior, Animal/drug effects
MH  - Brain/drug effects/metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Depression/*drug therapy/metabolism/physiopathology/psychology
MH  - Disease Models, Animal
MH  - Hindlimb Suspension
MH  - Hippocampus/metabolism
MH  - Humans
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Stress, Psychological
OTO - NOTNLM
OT  - amygdala
OT  - brain-derived neurotrophic factor
OT  - chronic immobilization stress
OT  - depression
OT  - hippocampus
OT  - pharmacopuncture
EDAT- 2017/12/26 06:00
MHDA- 2018/06/05 06:00
CRDT- 2017/12/26 06:00
PHST- 2017/06/12 00:00 [received]
PHST- 2017/08/22 00:00 [revised]
PHST- 2017/08/24 00:00 [accepted]
PHST- 2017/12/26 06:00 [entrez]
PHST- 2017/12/26 06:00 [pubmed]
PHST- 2018/06/05 06:00 [medline]
AID - S2005-2901(17)30113-9 [pii]
AID - 10.1016/j.jams.2017.08.007 [doi]
PST - ppublish
SO  - J Acupunct Meridian Stud. 2017 Dec;10(6):402-408. doi: 
      10.1016/j.jams.2017.08.007. Epub 2017 Aug 30.