PMID- 29276151
OWN - NLM
STAT- MEDLINE
DCOM- 20181226
LR  - 20231213
IS  - 2213-6711 (Electronic)
IS  - 2213-6711 (Linking)
VI  - 10
IP  - 1
DP  - 2018 Jan 9
TI  - BMAL1 Deficiency Contributes to Mandibular Dysplasia by Upregulating MMP3.
PG  - 180-195
LID - S2213-6711(17)30524-6 [pii]
LID - 10.1016/j.stemcr.2017.11.017 [doi]
AB  - Skeletal mandibular hypoplasia (SMH), one of the common types of craniofacial 
      deformities, seriously affects appearance, chewing, pronunciation, and breathing. 
      Moreover, SMH is prone to inducing obstructive sleep apnea syndrome. We found 
      that brain and muscle ARNT-like 1 (BMAL1), the core component of the molecular 
      circadian oscillator, was significantly decreased in mandibles of juvenile SMH 
      patients. Accordingly, SMH was observed in circadian-rhythm-disrupted or 
      BMAL1-deficient mice. RNA sequencing and protein chip analyses suggested that 
      matrix metallopeptidase 3 (MMP3) is the potential target of BMAL1. Interestingly, 
      in juvenile SMH patients, we observed that MMP3 was obviously increased. 
      Consistently, MMP3 was upregulated during the whole growth period of 3-10 weeks 
      in Bmal1(-/-) mice. Given these findings, we set out to characterize the 
      underlying mechanism and found BMAL1 deficiency enhanced Mmp3 transcription 
      through activating p65 phosphorylation. Together, our results provide insight 
      into the mechanism by which BMAL1 is implicated in the pathogenesis of SMH.
CI  - Copyright (c) 2017 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Zhao, Jiajia
AU  - Zhao J
AD  - Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430022, China.
FAU - Zhou, Xin
AU  - Zhou X
AD  - Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430022, China.
FAU - Tang, Qingming
AU  - Tang Q
AD  - Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430022, China.
FAU - Yu, Ran
AU  - Yu R
AD  - Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430022, China.
FAU - Yu, Shaoling
AU  - Yu S
AD  - Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430022, China.
FAU - Long, Yanlin
AU  - Long Y
AD  - Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430022, China.
FAU - Cao, Cen
AU  - Cao C
AD  - Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430022, China.
FAU - Han, Jun
AU  - Han J
AD  - Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430022, China.
FAU - Shi, Anbing
AU  - Shi A
AD  - Department of Biochemistry and Molecular Biology, School of Basic Medicine and 
      the Collaborative Innovation Center for Brain Science, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan 430030, China.
FAU - Mao, Jeremy J
AU  - Mao JJ
AD  - Center for Craniofacial Regeneration, College of Dental Medicine, Columbia 
      University Medical Center, New York, NY 10032, USA.
FAU - Chen, Xiong
AU  - Chen X
AD  - Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430022, China.
FAU - Chen, Lili
AU  - Chen L
AD  - Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430022, China. Electronic address: 
      lily-c1030@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171221
PL  - United States
TA  - Stem Cell Reports
JT  - Stem cell reports
JID - 101611300
RN  - 0 (ARNTL Transcription Factors)
RN  - 0 (BMAL1 protein, human)
RN  - 0 (Bmal1 protein, mouse)
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
RN  - EC 3.4.24.17 (Mmp3 protein, mouse)
SB  - IM
MH  - ARNTL Transcription Factors/*deficiency
MH  - Animals
MH  - Child
MH  - Female
MH  - *Gene Expression Regulation, Enzymologic
MH  - Humans
MH  - Male
MH  - Mandibular Diseases/genetics/*metabolism/pathology
MH  - Matrix Metalloproteinase 3/*biosynthesis/genetics
MH  - Mice
MH  - Mice, Knockout
MH  - *Up-Regulation
PMC - PMC5768965
OTO - NOTNLM
OT  - BMAL1
OT  - circadian clock gene
OT  - circadian rhythm
OT  - metallopeptidase 3
OT  - p65
OT  - skeletal mandibular hypoplasia
EDAT- 2017/12/26 06:00
MHDA- 2018/12/27 06:00
PMCR- 2017/12/21
CRDT- 2017/12/26 06:00
PHST- 2017/04/16 00:00 [received]
PHST- 2017/11/23 00:00 [revised]
PHST- 2017/11/24 00:00 [accepted]
PHST- 2017/12/26 06:00 [pubmed]
PHST- 2018/12/27 06:00 [medline]
PHST- 2017/12/26 06:00 [entrez]
PHST- 2017/12/21 00:00 [pmc-release]
AID - S2213-6711(17)30524-6 [pii]
AID - 10.1016/j.stemcr.2017.11.017 [doi]
PST - ppublish
SO  - Stem Cell Reports. 2018 Jan 9;10(1):180-195. doi: 10.1016/j.stemcr.2017.11.017. 
      Epub 2017 Dec 21.