PMID- 29277119
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20181211
IS  - 1744-4160 (Electronic)
IS  - 1381-3455 (Linking)
VI  - 124
IP  - 5
DP  - 2018 Dec
TI  - Brain-derived neurotropic factor (BDNF) heterozygous mice are more susceptible to 
      synaptic protein loss in cerebral cortex during high fat diet.
PG  - 442-447
LID - 10.1080/13813455.2017.1420666 [doi]
AB  - In this study we aimed to investigate whether reduced BDNF levels aggravate the 
      susceptibility of the brain to hazardous effects of high fat diet. For this 
      purpose, we fed BDNF heterozygous mice and wild type littermates with normal and 
      high fat diet for 16 weeks. Concentrations of two synaptic proteins (SNAP-25 and 
      PSD-95) and oxidative stress parameters (MDA, SOD, CAT) were evaluated in the 
      cortex after diet period. Interestingly, body weights of BDNF heterozygous groups 
      fed with control diet were higher than their littermates and heterozygous mice 
      fed with HFD were the heaviest in all experimental groups. MDA levels were 
      significantly elevated in both HFD groups (wild type and BDNF(+/-)). Synaptic 
      markers PSD-95 and SNAP-25 markedly decreased in BDNF(+/-) group fed with HFD 
      compared to other groups. In conclusion, we suggest that endogenous BDNF has an 
      important and possibly protective role in diet-induced changes in the cortex.
FAU - Abidin, Ismail
AU  - Abidin I
AD  - a Department of Biophysics, Faculty of Medicine , Karadeniz Technical University 
      , Trabzon , Turkey.
FAU - Aydin-Abidin, Selcen
AU  - Aydin-Abidin S
AD  - a Department of Biophysics, Faculty of Medicine , Karadeniz Technical University 
      , Trabzon , Turkey.
FAU - Bodur, Akin
AU  - Bodur A
AD  - b Department of Medical Biochemistry, Faculty of Medicine , Karadeniz Technical 
      University , Trabzon , Turkey.
FAU - Ince, Imran
AU  - Ince I
AD  - b Department of Medical Biochemistry, Faculty of Medicine , Karadeniz Technical 
      University , Trabzon , Turkey.
FAU - Alver, Ahmet
AU  - Alver A
AD  - b Department of Medical Biochemistry, Faculty of Medicine , Karadeniz Technical 
      University , Trabzon , Turkey.
LA  - eng
PT  - Journal Article
DEP - 20171225
PL  - England
TA  - Arch Physiol Biochem
JT  - Archives of physiology and biochemistry
JID - 9510153
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Disks Large Homolog 4 Protein)
RN  - 0 (Dlg4 protein, mouse)
RN  - 0 (Snap25 protein, mouse)
RN  - 0 (Synaptosomal-Associated Protein 25)
SB  - IM
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Cerebral Cortex/enzymology/*metabolism/pathology
MH  - Crosses, Genetic
MH  - Diet, High-Fat/*adverse effects
MH  - Disease Susceptibility
MH  - Disks Large Homolog 4 Protein/metabolism
MH  - Heterozygote
MH  - Lipid Peroxidation
MH  - Male
MH  - Mice, Knockout
MH  - Neurons/enzymology/metabolism/pathology
MH  - *Neuroprotection
MH  - Overweight/etiology/*metabolism/pathology
MH  - *Oxidative Stress
MH  - Reproducibility of Results
MH  - Synapses/enzymology/*metabolism/pathology
MH  - Synaptosomal-Associated Protein 25/metabolism
MH  - Weight Gain
OTO - NOTNLM
OT  - BDNF
OT  - High fat diet
OT  - mice cortex
OT  - oxidative stress
OT  - synaptic proteins
EDAT- 2017/12/27 06:00
MHDA- 2018/12/12 06:00
CRDT- 2017/12/27 06:00
PHST- 2017/12/27 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2017/12/27 06:00 [entrez]
AID - 10.1080/13813455.2017.1420666 [doi]
PST - ppublish
SO  - Arch Physiol Biochem. 2018 Dec;124(5):442-447. doi: 
      10.1080/13813455.2017.1420666. Epub 2017 Dec 25.