PMID- 29279060
OWN - NLM
STAT- MEDLINE
DCOM- 20190204
LR  - 20190215
IS  - 1539-6304 (Electronic)
IS  - 1088-5412 (Print)
IS  - 1088-5412 (Linking)
VI  - 39
IP  - 1
DP  - 2018 Jan 1
TI  - Heterogeneity of asthma and the risk of celiac disease in children.
PG  - 51-58
LID - 10.2500/aap.2018.39.4100 [doi]
AB  - BACKGROUND: Although human leukocyte antigen (HLA)-DR and HLA-DQ genes and gluten 
      play crucial roles in developing celiac disease (CD), most patients with these 
      risk factors still do not develop CD, which indicates additional unrecognized 
      risk factors. OBJECTIVE: To determine the association between asthma and the risk 
      of CD in children. METHODS: We conducted a population-based retrospective 
      case-control study in children who resided in Olmsted County, Minnesota. We 
      identified children with CD (cases) between January 1, 1997, and December 31, 
      2014, and compared these with children without CD (controls) (1:2 matching). 
      Asthma status was ascertained by using the predetermined asthma criteria (PAC) 
      and the asthma predictive index (API). Data analysis included conditional 
      logistic regression models and an unsupervised network analysis by using an 
      independent phenome-wide association scan (PheWAS) data set. RESULTS: Although 
      asthma status as determined by using PAC was not associated with the risk of CD 
      (odds ratio [OR] 1.4 [95% confidence interval CI, 0.8-2.5]; p = 0.2), asthma 
      status by using the API was significantly associated (OR 2.8 [95% CI, 1.3-6.0]; p 
      = 0.008). A subgroup analysis indicated that children with both asthma as 
      determined by using PAC and a family history of asthma had an increased risk of 
      CD compared with those without asthma (OR 2.28 [95% CI, 1.11-4.67]; p = 0.024). 
      PheWAS data showed a cluster of asthma single nucleotide polymorphisms and 
      patients with CD. CONCLUSION: A subgroup of children with asthma who also had a 
      family history of asthma seemed to be at an increased risk of CD, and, thus, the 
      third factor that underlies the risk of CD might be related to genetic factors 
      for asthma. Heterogeneity of asthma plays a role in determining the risk of 
      asthma-related comorbidity.
FAU - Patel, Bhavisha
AU  - Patel B
FAU - Wi, Chung-Il
AU  - Wi CI
FAU - Hasassri, M Earth
AU  - Hasassri ME
FAU - Divekar, Rohit
AU  - Divekar R
FAU - Absah, Imad
AU  - Absah I
FAU - Almallouhi, Eyad
AU  - Almallouhi E
FAU - Ryu, Euijung
AU  - Ryu E
FAU - King, Katherine
AU  - King K
FAU - Juhn, Young J
AU  - Juhn YJ
LA  - eng
GR  - R01 AG034676/AG/NIA NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
SB  - IM
MH  - Adolescent
MH  - Asthma/complications/epidemiology/*genetics
MH  - Case-Control Studies
MH  - Celiac Disease/*etiology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Medical History Taking
MH  - Polymorphism, Single Nucleotide
MH  - Retrospective Studies
MH  - Risk Factors
PMC - PMC5743845
COIS- Y.J. Juhn is the principal investigator of the Innovative Methods to Improve 
      Asthma Disease Management Award supported from Genentech, which has no 
      relationship with the work presented in this article. The remaining authors have 
      no conflicts of interest pertaining to this article
EDAT- 2017/12/28 06:00
MHDA- 2019/02/05 06:00
PMCR- 2018/01/01
CRDT- 2017/12/28 06:00
PHST- 2017/12/28 06:00 [entrez]
PHST- 2017/12/28 06:00 [pubmed]
PHST- 2019/02/05 06:00 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - AAP120-17 [pii]
AID - 10.2500/aap.2018.39.4100 [doi]
PST - ppublish
SO  - Allergy Asthma Proc. 2018 Jan 1;39(1):51-58. doi: 10.2500/aap.2018.39.4100.