PMID- 29279061
OWN - NLM
STAT- MEDLINE
DCOM- 20190204
LR  - 20190215
IS  - 1539-6304 (Electronic)
IS  - 1088-5412 (Linking)
VI  - 39
IP  - 1
DP  - 2018 Jan 1
TI  - Characteristics of beef allergy in schoolchildren in Turkey.
PG  - 59-65
LID - 10.2500/aap.2018.39.4098 [doi]
AB  - BACKGROUND: The prevalence of immunoglobulin E (IgE) mediated beef allergy in 
      childhood is unknown. We investigated the prevalence and characteristics of 
      IgE-mediated beef allergy in urban schoolchildren. METHODS: This cross-sectional 
      study recruited 6000 randomly selected urban schoolchildren ages 6-17 years from 
      the city center of Giresun in the eastern Black Sea region of Turkey during 2013. 
      Children with suspected IgE-mediated beef allergy, determined by a 
      self-administered questionnaire, after providing written consent, were skin-prick 
      tested with commercial beef and cow's milk solutions and prick-prick tested with 
      raw, boiled, and fried beef. Levels of serum-specific IgE to beef specific IgE 
      and serum-specific IgE to cow's milk were determined by using fluorescent enzyme 
      immunoassay. All children with suspected beef allergy were invited for a 
      double-blind, placebo controlled food challenge (DBPCFC) to determine the 
      prevalence of IgE-mediated beef allergy. RESULTS: The response rate to the 
      questionnaire was 82.2%. The estimated prevalence of parental-reported 
      IgE-mediated beef allergy was 2.6%. The prevalence of IgE-mediated beef allergy 
      confirmed by DBPCFC was 0.30% (95% confidence interval, 0.18-0.5%). Positive 
      challenge responses were observed in 70.6% (p = 0.027), 76.9% (p = 0.027), and 
      73.3% (p = 0.028) of the children with a positive family history of beef allergy, 
      positive skin test results, and positive beef specific IgE values, respectively. 
      A beef specific IgE value of >5 kUA/L alone or a combination of a positive family 
      history of beef allergy, positive skin test results, and beef specific IgE values 
      of >3 kUA/L yielded a positive response to DBPCFC. CONCLUSION: The presence of a 
      family history of beef allergy, beef specific IgE value, and skin test result 
      positivity are independently associated with positive DBPCFC results, and 
      combined evaluation of these three parameters increased the positive predictive 
      power of the tests.
FAU - Topcu, Zekiye Ilke Kilic
AU  - Topcu ZIK
FAU - Kaklikkaya, Nese
AU  - Kaklikkaya N
FAU - Baki, Ali
AU  - Baki A
FAU - Orhan, Fazil
AU  - Orhan F
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Animals
MH  - Cattle
MH  - Child
MH  - Cross-Sectional Studies
MH  - Female
MH  - Food Hypersensitivity/epidemiology/*immunology
MH  - Humans
MH  - Immunoglobulin E/analysis
MH  - Male
MH  - Medical History Taking
MH  - Predictive Value of Tests
MH  - Prevalence
MH  - Red Meat/*adverse effects
MH  - Skin Tests
MH  - Turkey
EDAT- 2017/12/28 06:00
MHDA- 2019/02/05 06:00
CRDT- 2017/12/28 06:00
PHST- 2017/12/28 06:00 [entrez]
PHST- 2017/12/28 06:00 [pubmed]
PHST- 2019/02/05 06:00 [medline]
AID - 10.2500/aap.2018.39.4098 [doi]
PST - ppublish
SO  - Allergy Asthma Proc. 2018 Jan 1;39(1):59-65. doi: 10.2500/aap.2018.39.4098.