PMID- 29279454
OWN - NLM
STAT- MEDLINE
DCOM- 20180820
LR  - 20180820
IS  - 1884-2836 (Electronic)
IS  - 1344-6304 (Linking)
VI  - 71
IP  - 2
DP  - 2018 Mar 22
TI  - Human Parainfluenza Virus Type 3 Infections in Patients with Hematopoietic Stem 
      Cell Transplants: the Mode of Nosocomial Infections and Prognosis.
PG  - 109-115
LID - 10.7883/yoken.JJID.2017.424 [doi]
AB  - There have been a few prospective and comprehensive surveillance studies on the 
      respiratory viral infections (RVIs) among patients undergoing hematopoietic stem 
      cell transplantation (HSCT). A 2-year prospective cohort surveillance study of 
      symptomatic and asymptomatic RVIs was performed in hospitalized HSCT patients. 
      Oropharyngeal (OP) swab samples were serially collected each week from 1 week 
      before and up to 100 days after HSCT and were tested for virus isolation with 
      cell culture-based viral isolation (CC-based VI) and a multiplex PCR (MPCR). A 
      total of 2,747 OP swab samples were collected from 250 HSCT patients (268 HSCT 
      procedures). Among these patients, 79 had RVIs (CC-based VI, n = 63; MPCR, n = 
      17). The parainfluenza virus type 3 (PIV3) accounted for 71% (57/80) of the cases 
      of RVIs. Some PIV3 infections were asymptomatic and involved a longer 
      virus-shedding period. The PIV3 was often cultured from samples taken before the 
      onset of a respiratory disease. The PIV3 infections were attributed to the 
      transmission of nosocomial infections. PIV3 infections before engraftment will 
      more likely result in the development of lower respiratory tract infections and 
      worse outcomes. A real-time monitoring of respiratory viral infections in the 
      HSCT ward among patients with or without respiratory symptoms is required for the 
      prevention of nosocomial RVIs, especially of PIV3 infections.
FAU - Kakiuchi, Satsuki
AU  - Kakiuchi S
AD  - Department of Virology 1, National Institute of Infectious Diseases.
AD  - Department of Developmental Medical Sciences, The University of Tokyo.
FAU - Tsuji, Masanori
AU  - Tsuji M
AD  - Department of Hematology, Toranomon Hospital.
FAU - Nishimura, Hidekazu
AU  - Nishimura H
AD  - Virus Research Center, Sendai Medical Center.
FAU - Wang, Lixing
AU  - Wang L
AD  - Department of Virology 1, National Institute of Infectious Diseases.
FAU - Takayama-Ito, Mutsuyo
AU  - Takayama-Ito M
AD  - Department of Virology 1, National Institute of Infectious Diseases.
FAU - Kinoshita, Hitomi
AU  - Kinoshita H
AD  - Department of Virology 1, National Institute of Infectious Diseases.
FAU - Lim, Chang-Kweng
AU  - Lim CK
AD  - Department of Virology 1, National Institute of Infectious Diseases.
FAU - Taniguchi, Shuichi
AU  - Taniguchi S
AD  - Department of Hematology, Toranomon Hospital.
FAU - Oka, Akira
AU  - Oka A
AD  - Department of Developmental Medical Sciences, The University of Tokyo.
FAU - Mizuguchi, Masashi
AU  - Mizuguchi M
AD  - Department of Pediatrics, Graduate School of Medicine, The University of Tokyo.
FAU - Saijo, Masayuki
AU  - Saijo M
AD  - Department of Virology 1, National Institute of Infectious Diseases.
AD  - Department of Pediatrics, Graduate School of Medicine, The University of Tokyo.
LA  - eng
PT  - Journal Article
DEP - 20171226
PL  - Japan
TA  - Jpn J Infect Dis
JT  - Japanese journal of infectious diseases
JID - 100893704
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Cross Infection/epidemiology/virology
MH  - Hematopoietic Stem Cell Transplantation/*statistics & numerical data
MH  - Hospitalization
MH  - Humans
MH  - Immunocompromised Host
MH  - Middle Aged
MH  - Oropharynx/virology
MH  - Parainfluenza Virus 3, Human/*genetics
MH  - Polymerase Chain Reaction
MH  - Prognosis
MH  - Prospective Studies
MH  - *Respiratory Tract Infections/epidemiology/virology
MH  - *Respirovirus Infections/epidemiology/virology
MH  - Young Adult
OTO - NOTNLM
OT  - hematopoietic stem cell transplantation
OT  - human parainfluenza virus type 3
OT  - immunocompromised patients
OT  - respiratory virus infection
EDAT- 2017/12/28 06:00
MHDA- 2018/08/21 06:00
CRDT- 2017/12/28 06:00
PHST- 2017/12/28 06:00 [pubmed]
PHST- 2018/08/21 06:00 [medline]
PHST- 2017/12/28 06:00 [entrez]
AID - 10.7883/yoken.JJID.2017.424 [doi]
PST - ppublish
SO  - Jpn J Infect Dis. 2018 Mar 22;71(2):109-115. doi: 10.7883/yoken.JJID.2017.424. 
      Epub 2017 Dec 26.