PMID- 29279552
OWN - NLM
STAT- MEDLINE
DCOM- 20180731
LR  - 20200225
IS  - 1880-9952 (Electronic)
IS  - 1346-4280 (Print)
IS  - 1346-4280 (Linking)
VI  - 57
IP  - 3
DP  - 2017
TI  - Nephrotic syndrome during the tapering of oral steroids after pathological 
      diagnosis of Kimura disease from a lacrimal gland mass: case report and review of 
      10 Japanese patients.
PG  - 147-152
LID - 10.3960/jslrt.17028 [doi]
AB  - A 42-year-old man with eosinophilia and high serum immunoglobulin E (IgE) 
      developed a lacrimal gland mass on the left side. Excisional biopsy revealed 
      hyperplasia of lymphoid follicles, and infiltration with lymphocytes and 
      eosinophils around lacrimal gland acini, leading to the pathological diagnosis of 
      Kimura disease. IgE-positive cells were mainly found along follicular dendritic 
      cells, and a small number of IgG4-positive cells was present. One month after 
      oral prednisolone was started at 40 mg daily and tapered to 10 mg daily, he 
      developed lower leg edema on both sides and marked proteinuria (10.8 g/day). 
      Renal biopsy showed no glomerular abnormalities, no immunoglobulin deposition, 
      and no tubulointerstitial infiltration with eosinophils, leading to the diagnosis 
      of minimal change nephrotic syndrome. Proteinuria subsided in response to an 
      increased dose of prednisolone to 30 mg daily. Proteinuria relapsed three times 
      in the following 5 years when oral prednisolone was tapered. In conclusion, 
      Kimura disease manifested as an orbital mass and did not relapse. However, 
      nephrotic syndrome relapsed frequently with background eosinophilia and high 
      serum IgE. This study reviewed the clinical features of 10 Japanese patients with 
      Kimura disease associated with proteinuria.
FAU - Matsuo, Toshihiko
AU  - Matsuo T
AD  - Department of Ophthalmology, Okayama University Hospital and Okayama University 
      Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences.
FAU - Tanaka, Takehiro
AU  - Tanaka T
AD  - Department of Pathology Okayama University Hospital and Okayama University 
      Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences.
FAU - Kinomura, Masaru
AU  - Kinomura M
AD  - Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama 
      University Hospital and Okayama University Graduate School of Medicine, 
      Dentistry, and Pharmaceutical Sciences.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - J Clin Exp Hematop
JT  - Journal of clinical and experimental hematopathology : JCEH
JID - 101141257
RN  - 0 (Glucocorticoids)
RN  - 0 (Immunoglobulin G)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9PHQ9Y1OLM (Prednisolone)
SB  - IM
MH  - Adult
MH  - Angiolymphoid Hyperplasia with Eosinophilia/blood/*complications/drug 
      therapy/pathology
MH  - Glucocorticoids/*therapeutic use
MH  - Humans
MH  - Immunoglobulin E/analysis/blood
MH  - Immunoglobulin G/analysis/blood
MH  - Lacrimal Apparatus/drug effects/pathology
MH  - Male
MH  - Nephrotic Syndrome/blood/*complications/drug therapy/pathology
MH  - Prednisolone/*therapeutic use
MH  - Proteinuria/blood/*complications/drug therapy/pathology
PMC - PMC6144185
OTO - NOTNLM
OT  - IgG4
OT  - Kimura disease
OT  - lacrimal gland
OT  - nephrotic syndrome
OT  - renal biopsy
COIS- CONFLICT OF INTEREST: The authors declare no conflict of interest in this study.
EDAT- 2017/12/28 06:00
MHDA- 2018/08/01 06:00
PMCR- 2017/12/27
CRDT- 2017/12/28 06:00
PHST- 2017/12/28 06:00 [entrez]
PHST- 2017/12/28 06:00 [pubmed]
PHST- 2018/08/01 06:00 [medline]
PHST- 2017/12/27 00:00 [pmc-release]
AID - 17028 [pii]
AID - 10.3960/jslrt.17028 [doi]
PST - ppublish
SO  - J Clin Exp Hematop. 2017;57(3):147-152. doi: 10.3960/jslrt.17028.