PMID- 29279850
OWN - NLM
STAT- MEDLINE
DCOM- 20180727
LR  - 20181113
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2017
DP  - 2017
TI  - An Improved Binary Differential Evolution Algorithm to Infer Tumor Phylogenetic 
      Trees.
PG  - 5482750
LID - 10.1155/2017/5482750 [doi]
LID - 5482750
AB  - Tumourigenesis is a mutation accumulation process, which is likely to start with 
      a mutated founder cell. The evolutionary nature of tumor development makes 
      phylogenetic models suitable for inferring tumor evolution through genetic 
      variation data. Copy number variation (CNV) is the major genetic marker of the 
      genome with more genes, disease loci, and functional elements involved. 
      Fluorescence in situ hybridization (FISH) accurately measures multiple gene copy 
      number of hundreds of single cells. We propose an improved binary differential 
      evolution algorithm, BDEP, to infer tumor phylogenetic tree based on FISH 
      platform. The topology analysis of tumor progression tree shows that the pathway 
      of tumor subcell expansion varies greatly during different stages of tumor 
      formation. And the classification experiment shows that tree-based features are 
      better than data-based features in distinguishing tumor. The constructed 
      phylogenetic trees have great performance in characterizing tumor development 
      process, which outperforms other similar algorithms.
FAU - Liang, Ying
AU  - Liang Y
AUID- ORCID: 0000-0001-9092-2110
AD  - College of Information Science and Engineering, Hunan University, Changsha, 
      China.
FAU - Liao, Bo
AU  - Liao B
AUID- ORCID: 0000-0001-7391-4063
AD  - College of Information Science and Engineering, Hunan University, Changsha, 
      China.
FAU - Zhu, Wen
AU  - Zhu W
AUID- ORCID: 0000-0002-1870-9400
AD  - College of Information Science and Engineering, Hunan University, Changsha, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20171127
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
SB  - IM
MH  - Carcinogenesis/*genetics
MH  - DNA Copy Number Variations/genetics
MH  - *Evolution, Molecular
MH  - Gene Dosage/genetics
MH  - Genome, Human
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Models, Genetic
MH  - Neoplasms/*genetics/pathology
MH  - *Phylogeny
MH  - Software
PMC - PMC5723949
EDAT- 2017/12/28 06:00
MHDA- 2018/07/28 06:00
PMCR- 2017/11/27
CRDT- 2017/12/28 06:00
PHST- 2017/09/02 00:00 [received]
PHST- 2017/10/18 00:00 [accepted]
PHST- 2017/12/28 06:00 [entrez]
PHST- 2017/12/28 06:00 [pubmed]
PHST- 2018/07/28 06:00 [medline]
PHST- 2017/11/27 00:00 [pmc-release]
AID - 10.1155/2017/5482750 [doi]
PST - ppublish
SO  - Biomed Res Int. 2017;2017:5482750. doi: 10.1155/2017/5482750. Epub 2017 Nov 27.