PMID- 29280414 OWN - NLM STAT- MEDLINE DCOM- 20190701 LR - 20190701 IS - 1476-8305 (Electronic) IS - 1028-415X (Linking) VI - 22 IP - 7 DP - 2019 Jul TI - The relationship between dietary quality, serum brain-derived neurotrophic factor (BDNF) level, and the Val66met polymorphism in predicting depression. PG - 513-521 LID - 10.1080/1028415X.2017.1415281 [doi] AB - BACKGROUND: Brain-derived neurotrophic factor (BDNF), a neurotrophic factor implicated in the pathogenesis of depression, may be influenced by dietary quality. Both dietary quality and serum BDNF have been researched independently in regard to their effect on depression; however, there is limited research investigating the relationship between the two factors and how they interact in depression. Additionally, a single-nucleotide polymorphism (SNP) (Val66Met) in the BDNF gene, which has been implicated in BDNF levels and depression, may contribute to the complex relationship between depression, dietary quality, and BDNF level. METHODS: One hundred and eighty-seven participants with major depressive disorder and 55 non-depressed healthy controls were recruited for this case-control analysis. The relationship between dietary quality and depression was assessed via a novel dietary quality score (the Australian Dietary Quality Score). Serum BDNF levels were measured and the Val66Met SNP was genotyped. RESULTS: Healthy controls had a significantly higher diet quality than depressed participants (t = 2.435, P = 0.016). A logistic regression model investigating age, sex, serum BDNF levels, dietary quality and depression, as well as any interactions, found that lower dietary quality, and surprisingly, higher BDNF levels, were associated with increased depression risk, P = 0.037 and P < 0.001, respectively. Neither seasonality (at the time of recruitment) nor the Val66Met polymorphism was associated with BDNF levels in this sample. Furthermore, there was no evidence of interaction between the Val66Met polymorphism, BDNF levels, dietary quality, and depression. CONCLUSION: Higher dietary quality was associated with both decreased depression incidence and severity in this cross-sectional analysis. The Val66Met polymorphism did not appear to predict BDNF levels, depression incidence, or modify the relationship between dietary quality and BDNF. Further studies utilizing a larger sample size are needed to confirm this finding. FAU - Froud, Amy AU - Froud A AUID- ORCID: 0000-0002-5656-1398 AD - a ARCADIA Mental Health Research Group, Professorial Unit, The Melbourne Clinic, Department of Psychiatry , University of Melbourne , 2 Salisbury St, Melbourne 3121 , Australia. FAU - Murphy, Jenifer AU - Murphy J AD - a ARCADIA Mental Health Research Group, Professorial Unit, The Melbourne Clinic, Department of Psychiatry , University of Melbourne , 2 Salisbury St, Melbourne 3121 , Australia. FAU - Cribb, Lachlan AU - Cribb L AD - a ARCADIA Mental Health Research Group, Professorial Unit, The Melbourne Clinic, Department of Psychiatry , University of Melbourne , 2 Salisbury St, Melbourne 3121 , Australia. FAU - Ng, Chee H AU - Ng CH AD - a ARCADIA Mental Health Research Group, Professorial Unit, The Melbourne Clinic, Department of Psychiatry , University of Melbourne , 2 Salisbury St, Melbourne 3121 , Australia. FAU - Sarris, Jerome AU - Sarris J AD - a ARCADIA Mental Health Research Group, Professorial Unit, The Melbourne Clinic, Department of Psychiatry , University of Melbourne , 2 Salisbury St, Melbourne 3121 , Australia. AD - b NICM, School of Science and Health, Western Sydney University , Australia. LA - eng PT - Journal Article DEP - 20171227 PL - England TA - Nutr Neurosci JT - Nutritional neuroscience JID - 100892202 RN - 0 (Antidepressive Agents) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - Adult MH - Antidepressive Agents/therapeutic use MH - Brain-Derived Neurotrophic Factor/*blood MH - Case-Control Studies MH - Depressive Disorder, Major/*blood/drug therapy/*genetics MH - *Diet MH - Female MH - Genotype MH - Humans MH - Male MH - Middle Aged MH - Nutrition Surveys MH - Polymorphism, Single Nucleotide OTO - NOTNLM OT - BDNF OT - Brain-derived neurotrophic factor OT - Depression OT - Dietary quality OT - Lifestyle OT - Nutrition OT - Val66met EDAT- 2017/12/28 06:00 MHDA- 2019/07/02 06:00 CRDT- 2017/12/28 06:00 PHST- 2017/12/28 06:00 [pubmed] PHST- 2019/07/02 06:00 [medline] PHST- 2017/12/28 06:00 [entrez] AID - 10.1080/1028415X.2017.1415281 [doi] PST - ppublish SO - Nutr Neurosci. 2019 Jul;22(7):513-521. doi: 10.1080/1028415X.2017.1415281. Epub 2017 Dec 27.