PMID- 29281127
OWN - NLM
STAT- MEDLINE
DCOM- 20191023
LR  - 20191023
IS  - 1523-4681 (Electronic)
IS  - 0884-0431 (Print)
IS  - 0884-0431 (Linking)
VI  - 33
IP  - 5
DP  - 2018 May
TI  - Bone Tissue Collagen Maturity and Mineral Content Increase With Sustained 
      Hyperglycemia in the KK-Ay Murine Model of Type 2 Diabetes.
PG  - 921-929
LID - 10.1002/jbmr.3365 [doi]
AB  - Type 2 diabetes mellitus (T2DM) increases fracture risk for a given bone mineral 
      density (BMD), which suggests that T2DM changes bone tissue properties 
      independently of bone mass. In this study, we assessed the effects of 
      hyperglycemia on bone tissue compositional properties, enzymatic collagen 
      crosslinks, and advanced glycation end-products (AGEs) in the KK-Ay murine model 
      of T2DM using Fourier transform infrared (FTIR) imaging and high-performance 
      liquid chromatography (HPLC). Compared to KK-aa littermate controls (n = 8), 
      proximal femoral bone tissue of KK-Ay mice (n = 14) exhibited increased collagen 
      maturity, increased mineral content, and less heterogeneous mineral properties. 
      AGE accumulation assessed by the concentration of pentosidine, as well as the 
      concentrations of the nonenzymatic crosslinks hydroxylysylpyridinoline (HP) and 
      lysyl pyridinoline (LP), did not differ in the proximal femurs of KK-Ay mice 
      compared to controls. The observed differences in tissue-level compositional 
      properties in the KK-Ay mice are consistent with bone that is older and echo 
      observations of reduced remodeling in T2DM. (c) 2017 American Society for Bone and 
      Mineral Research.
CI  - (c) 2017 American Society for Bone and Mineral Research.
FAU - Hunt, Heather B
AU  - Hunt HB
AD  - Department of Materials Science and Engineering, Cornell University, Ithaca, NY, 
      USA.
FAU - Pearl, Jared C
AU  - Pearl JC
AD  - Department of Materials Science and Engineering, Cornell University, Ithaca, NY, 
      USA.
FAU - Diaz, David R
AU  - Diaz DR
AD  - Department of Materials Science and Engineering, Cornell University, Ithaca, NY, 
      USA.
FAU - King, Karen B
AU  - King KB
AD  - Department of Orthopedics, University of Colorado School of Medicine, Aurora, CO, 
      USA.
AD  - Surgical Service/Orthopaedic Service, Veterans Affairs Eastern Colorado Health 
      Care System, Denver, CO, USA.
FAU - Donnelly, Eve
AU  - Donnelly E
AD  - Department of Materials Science and Engineering, Cornell University, Ithaca, NY, 
      USA.
AD  - Research Division, Hospital for Special Surgery, New York, NY, USA.
LA  - eng
GR  - K01 AR064314/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20180208
PL  - England
TA  - J Bone Miner Res
JT  - Journal of bone and mineral research : the official journal of the American 
      Society for Bone and Mineral Research
JID - 8610640
RN  - 0 (Glycation End Products, Advanced)
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Animals
MH  - *Bone Density
MH  - Collagen/*metabolism
MH  - Diabetes Mellitus, Experimental/*metabolism/pathology
MH  - Diabetes Mellitus, Type 2/*metabolism/pathology
MH  - Glycation End Products, Advanced/*metabolism
MH  - Hyperglycemia/*metabolism/pathology
MH  - Male
MH  - Mice
PMC - PMC5935591
MID - NIHMS947497
OTO - NOTNLM
OT  - COLLAGEN: BONE MATRIX
OT  - GENETIC ANIMAL MODELS: ANIMAL MODELS
OT  - MATRIX MINERALIZATION: BONE MATRIX
OT  - OTHER: ANALYSIS/QUANTITATION OF BONE
OT  - OTHER: DISEASES AND DISORDERS OF/RELATED TO BONE
COIS- Disclosures All authors state that they have no conflicts of interest.
EDAT- 2017/12/28 06:00
MHDA- 2019/10/24 06:00
PMCR- 2019/05/01
CRDT- 2017/12/28 06:00
PHST- 2017/08/14 00:00 [received]
PHST- 2017/12/01 00:00 [revised]
PHST- 2017/12/13 00:00 [accepted]
PHST- 2017/12/28 06:00 [pubmed]
PHST- 2019/10/24 06:00 [medline]
PHST- 2017/12/28 06:00 [entrez]
PHST- 2019/05/01 00:00 [pmc-release]
AID - 10.1002/jbmr.3365 [doi]
PST - ppublish
SO  - J Bone Miner Res. 2018 May;33(5):921-929. doi: 10.1002/jbmr.3365. Epub 2018 Feb 
      8.