PMID- 29281647
OWN - NLM
STAT- MEDLINE
DCOM- 20180129
LR  - 20220409
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 12
DP  - 2017
TI  - Repeat multiparametric MRI in prostate cancer patients on active surveillance.
PG  - e0189272
LID - 10.1371/journal.pone.0189272 [doi]
LID - e0189272
AB  - INTRODUCTION: This study was conducted to describe the changes in repeat 
      multiparametric MRI (mpMRI) occurring in prostate cancer (PCa) patients during 
      active surveillance (AS), and to study possible associations between 
      mpMRI-related parameters in predicting prostate biopsy (Bx) Gleason score (GS) 
      upgrading >3+3 and protocol-based treatment change (TC). MATERIALS AND METHODS: 
      The study cohort consisted of 76 AS patients with GS 3+3 PCa and at least two 
      consecutive mpMRIs of the prostate performed between 2006-2015. Patients were 
      followed according to the Prostate Cancer Research International Active 
      Surveillance (PRIAS) protocol and an additional mpMRI. The primary end points 
      were GS upgrading (GU) (>3+3) in protocol-based Bxs and protocol-based TC. 
      RESULTS: Out of 76 patients, 53 (69%) had progression (PIRADS upgrade, size 
      increase or new lesion[s]), while 18 (24%) had radiologically stable disease, and 
      5 (7%) had regression (PIRADS or size decrease, disappearance of lesion[s]) in 
      repeat mpMRIs during AS. PIRADS scores of 4-5 in the initial mpMRI were 
      associated with GU (p = 0.008) and protocol-based TC (p = 0.009). Tumour 
      progression on repeat mpMRIs was associated with TC (p = 0.045) but not with GU 
      (p = 1.00). PIRADS scores of 4-5 predict GU (sensitivity 0.80 [95% confidence 
      interval (CI); 0.51-0.95, specificity 0.62 [95% CI; 0.52-0.77]) with PPV and NPV 
      values of 0.34 (95% CI; 0.21-0.55) and 0.93 (95% CI; 0.80-0.98), respectively. 
      CONCLUSION: mpMRI is a useful tool not only to select but also to monitor PCa 
      patients on AS.
FAU - Eineluoto, Juho T
AU  - Eineluoto JT
AUID- ORCID: 0000-0003-1109-2994
AD  - Department of Urology, University of Helsinki and Helsinki University Hospital, 
      Helsinki, Finland.
FAU - Jarvinen, Petrus
AU  - Jarvinen P
AD  - Department of Urology, University of Helsinki and Helsinki University Hospital, 
      Helsinki, Finland.
FAU - Kenttamies, Anu
AU  - Kenttamies A
AD  - Medical Imaging Center, University of Helsinki and Helsinki University Hospital, 
      Helsinki, Finland.
FAU - Kilpelainen, Tuomas P
AU  - Kilpelainen TP
AD  - Department of Urology, University of Helsinki and Helsinki University Hospital, 
      Helsinki, Finland.
FAU - Vasarainen, Hanna
AU  - Vasarainen H
AD  - Department of Urology, University of Helsinki and Helsinki University Hospital, 
      Helsinki, Finland.
FAU - Sandeman, Kevin
AU  - Sandeman K
AD  - Department of Pathology (HUSLAB), University of Helsinki and Helsinki University 
      Hospital, Helsinki, Finland.
FAU - Erickson, Andrew
AU  - Erickson A
AD  - Department of Urology, University of Helsinki and Helsinki University Hospital, 
      Helsinki, Finland.
AD  - Department of Pathology (HUSLAB), University of Helsinki and Helsinki University 
      Hospital, Helsinki, Finland.
FAU - Mirtti, Tuomas
AU  - Mirtti T
AD  - Department of Pathology (HUSLAB), University of Helsinki and Helsinki University 
      Hospital, Helsinki, Finland.
AD  - Finnish Institute for Molecular Medicine, University of Helsinki and Helsinki 
      University Hospital, Helsinki, Finland.
AD  - Medicum, University of Helsinki and Helsinki University Hospital, Helsinki, 
      Finland.
FAU - Rannikko, Antti
AU  - Rannikko A
AD  - Department of Urology, University of Helsinki and Helsinki University Hospital, 
      Helsinki, Finland.
LA  - eng
PT  - Journal Article
DEP - 20171227
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biopsy
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Grading
MH  - Prostatic Neoplasms/*diagnostic imaging/pathology
MH  - *Watchful Waiting
PMC - PMC5744936
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2017/12/28 06:00
MHDA- 2018/01/30 06:00
PMCR- 2017/12/27
CRDT- 2017/12/28 06:00
PHST- 2017/08/02 00:00 [received]
PHST- 2017/11/22 00:00 [accepted]
PHST- 2017/12/28 06:00 [entrez]
PHST- 2017/12/28 06:00 [pubmed]
PHST- 2018/01/30 06:00 [medline]
PHST- 2017/12/27 00:00 [pmc-release]
AID - PONE-D-17-28674 [pii]
AID - 10.1371/journal.pone.0189272 [doi]
PST - epublish
SO  - PLoS One. 2017 Dec 27;12(12):e0189272. doi: 10.1371/journal.pone.0189272. 
      eCollection 2017.