PMID- 29281760
OWN - NLM
STAT- MEDLINE
DCOM- 20191023
LR  - 20191210
IS  - 1523-4681 (Electronic)
IS  - 0884-0431 (Linking)
VI  - 33
IP  - 5
DP  - 2018 May
TI  - Long-Term Complications in Patients With Hypoparathyroidism Evaluated by 
      Biochemical Findings: A Case-Control Study.
PG  - 822-831
LID - 10.1002/jbmr.3368 [doi]
AB  - Hypoparathyroidism (HypoPT) is associated with an increased risk of various 
      complications, but only few data are available on risk factors. Using a 
      case-control design, we assessed associations between biochemical findings and 
      risk of different complications within a subpopulation of our previously 
      identified Danish patients. We retrieved all biochemical data available on 431 
      (81% women) patients from the Central Region of Denmark, covering approximately 
      20% of the Danish population. Average age of patients was 41 years at time of 
      diagnosis. Most patients (88%) had HypoPT due to surgery, mainly due to atoxic 
      goiter and more than 95% were on treatment with calcium supplements and activated 
      vitamin D. On average, time-weighted (tw) plasma levels of ionized calcium 
      (Ca(2+)(tw) ) was 1.17 mmol/L (interquartile range [IQR], 1.14 to 1.21 mmol/L) 
      and the calcium-phosphate (CaxP(tw) ) product was 2.80 mmol(2) /L(2) (IQR, 2.51 
      to 3.03 mmol(2) /L(2) ). High phosphate(tw) levels were associated with increased 
      mortality and risk of any infections, including infections in the upper airways. 
      A high CaxP(tw) product was associated with an increased mortality and risk of 
      renal disease. Compared to levels around the lower part of the reference 
      interval, lower Ca(2+)(tw) levels were associated with an increased risk of 
      cardiovascular diseases. Mortality and risk of infections, cardiovascular 
      diseases, and renal diseases increased with number of episodes of hypercalcemia 
      and with increased disease duration. Treatment with a relatively high dose of 
      active vitamin D was associated with a decreased mortality and risk of renal 
      diseases and infections. In conclusion, risk of complications in HypoPT is 
      closely associated with disturbances in calcium-phosphate homeostasis. (c) 2018 
      American Society for Bone and Mineral Research.
CI  - (c) 2018 American Society for Bone and Mineral Research.
FAU - Underbjerg, Line
AU  - Underbjerg L
AD  - Department of Endocrinology and Internal Medicine, Aarhus University Hospital, 
      Aarhus, Denmark.
FAU - Sikjaer, Tanja
AU  - Sikjaer T
AD  - Department of Endocrinology and Internal Medicine, Aarhus University Hospital, 
      Aarhus, Denmark.
FAU - Rejnmark, Lars
AU  - Rejnmark L
AD  - Department of Endocrinology and Internal Medicine, Aarhus University Hospital, 
      Aarhus, Denmark.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20180214
PL  - England
TA  - J Bone Miner Res
JT  - Journal of bone and mineral research : the official journal of the American 
      Society for Bone and Mineral Research
JID - 8610640
RN  - 0 (Calcium, Dietary)
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Calcium, Dietary/*administration & dosage
MH  - *Cardiovascular Diseases/blood/etiology/mortality/prevention & control
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Denmark
MH  - Female
MH  - Goiter/blood/complications/drug therapy/mortality
MH  - Humans
MH  - *Hypoparathyroidism/blood/complications/drug therapy/mortality
MH  - Infant
MH  - Infant, Newborn
MH  - *Infections/blood/drug therapy/etiology/mortality
MH  - *Kidney Diseases/blood/etiology/mortality/prevention & control
MH  - Male
MH  - Middle Aged
MH  - *Registries
MH  - Risk Factors
MH  - Vitamin D/*administration & dosage
OTO - NOTNLM
OT  - COMPLICATIONS
OT  - EPIDEMIOLOGY BIOCHEMISTRY
OT  - HYPOPARATHYROIDISM
OT  - MORTALITY
EDAT- 2017/12/28 06:00
MHDA- 2019/10/24 06:00
CRDT- 2017/12/28 06:00
PHST- 2017/08/31 00:00 [received]
PHST- 2017/12/12 00:00 [revised]
PHST- 2017/12/18 00:00 [accepted]
PHST- 2017/12/28 06:00 [pubmed]
PHST- 2019/10/24 06:00 [medline]
PHST- 2017/12/28 06:00 [entrez]
AID - 10.1002/jbmr.3368 [doi]
PST - ppublish
SO  - J Bone Miner Res. 2018 May;33(5):822-831. doi: 10.1002/jbmr.3368. Epub 2018 Feb 
      14.