PMID- 29282075 OWN - NLM STAT- MEDLINE DCOM- 20180601 LR - 20240327 IS - 1477-7525 (Electronic) IS - 1477-7525 (Linking) VI - 15 IP - 1 DP - 2017 Dec 28 TI - Psychometric validation of a multi-dimensional capability instrument for outcome measurement in mental health research (OxCAP-MH). PG - 250 LID - 10.1186/s12955-017-0825-3 [doi] LID - 250 AB - BACKGROUND: Patient reported outcome measures (PROMs) are widely used in mental healthcare research for quality of life assessment but most fail to capture the breadth of health and non-health domains that can be impacted. We report the psychometric validation of a novel, multi-dimensional instrument based on Amartya Sen's capability approach intended for use as an outcome measure in mental health research. METHODS: The Oxford Capabilities Questionnaire for Mental Health (OxCAP-MH) is a 16-item self-complete capability measure that covers multiple domains of functioning and welfare. Data for validation of the instrument were collected through a national randomised controlled trial of community treatment orders for patients with psychosis. Complete OxCAP-MH data were available for 172 participants. Internal consistency was established with Cronbach's alpha; an interclass correlation coefficient was used to assess test-retest reliability in a sub-sample (N = 50) tested one week apart. Construct validity was established by comparing OxCAP-MH total scores with established instruments of illness severity and functioning: EuroQol (EQ-5D), Brief Psychiatric Rating Scale (BPRS), Global Assessment of Functioning (GAF) and Objective Social Outcomes Index (SIX). Sensitivity was established by calculating standard error of measurement using distributional methods. RESULTS: The OxCAP-MH showed good internal consistency (Cronbach's alpha 0.79) and test-retest reliability (ICC = 0.86). Convergent validity was evidenced by strong correlations with the EQ-5D (VAS 0.52, p < .001) (Utility 0.45, p < .001), and divergent validity through more modest associations with the BPRS (-0.41, p < .001), GAF (0.24, p < .001) and SIX (0.12, p = ns). A change of 9.2 points on a 0-100 scale was found to be meaningful on statistical grounds. CONCLUSIONS: The OxCAP-MH has demonstrable reliability and construct validity and represents a promising multi-dimensional alternative to existing patient-reported outcome measures for quality of life used in mental health research. FAU - Vergunst, Francis AU - Vergunst F AD - Research Unit on Children's Psychosocial Maladjustment, University of Montreal, Ste Justine Hospital, 3175 Chemin de la Cote Ste-Catherine, Montreal, H3T 1C5, Canada. AD - Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK. FAU - Jenkinson, Crispin AU - Jenkinson C AD - Health Services Research Unit, Nuffield Department of Population Health, University of Oxford, Richard Doll Building, Old Road Campus, Oxford, OX3 7LF, UK. FAU - Burns, Tom AU - Burns T AD - Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK. FAU - Anand, Paul AU - Anand P AD - Faculty of Arts and Social Sciences, The Open University, Milton Keynes, MK7 6AA, UK. AD - Centre for Philosophy of Natural and Social Sciences, London School of Economics, London, WC2A 2AE, UK. AD - Department of Social Policy and Intervention, University of Oxford, 32 -37 Wellington Square, Oxford, OX1 2ER, UK. FAU - Gray, Alastair AU - Gray A AD - Health Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Richard Doll Building, Old Road Campus, Oxford, OX3 7LF, UK. FAU - Rugkasa, Jorun AU - Rugkasa J AD - Health Services Research Unit, Akershus University Hospital, 1478, Lorenskog, Norway. AD - Centre for Care Research, University College of Southeast Norway, 3900, Porsgrunn, Norway. FAU - Simon, Judit AU - Simon J AUID- ORCID: 0000-0001-9279-8627 AD - Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK. judit.simon@meduniwien.ac.at. AD - Health Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Richard Doll Building, Old Road Campus, Oxford, OX3 7LF, UK. judit.simon@meduniwien.ac.at. AD - Department of Health Economics, Center for Public Health, Medical University of Vienna, Kinderspitalgasse 15, 1090, Vienna, Austria. judit.simon@meduniwien.ac.at. LA - eng GR - RP-PG-0606-1006/DH_/Department of Health/United Kingdom GR - RP-PG-0606-1006/National Institute for Health Research/ PT - Journal Article PT - Validation Study DEP - 20171228 PL - England TA - Health Qual Life Outcomes JT - Health and quality of life outcomes JID - 101153626 SB - IM MH - Adult MH - Female MH - *Health Services Research MH - Humans MH - Male MH - Mental Disorders/psychology/therapy MH - Mental Health Services/*standards MH - Middle Aged MH - Outcome Assessment, Health Care/*methods MH - Patient Reported Outcome Measures MH - Psychiatric Status Rating Scales MH - Psychometrics MH - Quality of Life/*psychology MH - Reproducibility of Results PMC - PMC5745777 OTO - NOTNLM OT - Capabilities OT - Community treatment orders OT - Mental health OT - Outcome measurement OT - Psychiatry OT - Psychometric validation OT - Psychosis COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: The study was granted ethical approval by the Staffordshire NHS Research Ethics Committee [REC ref. 08/H1204/131] and all patients gave informed consent prior to interview. CONSENT FOR PUBLICATION: Not applicable. COMPETING INTERESTS: The authors declare that they have no competing interests. PUBLISHER'S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. EDAT- 2017/12/29 06:00 MHDA- 2018/06/02 06:00 PMCR- 2017/12/28 CRDT- 2017/12/29 06:00 PHST- 2017/08/03 00:00 [received] PHST- 2017/12/12 00:00 [accepted] PHST- 2017/12/29 06:00 [entrez] PHST- 2017/12/29 06:00 [pubmed] PHST- 2018/06/02 06:00 [medline] PHST- 2017/12/28 00:00 [pmc-release] AID - 10.1186/s12955-017-0825-3 [pii] AID - 825 [pii] AID - 10.1186/s12955-017-0825-3 [doi] PST - epublish SO - Health Qual Life Outcomes. 2017 Dec 28;15(1):250. doi: 10.1186/s12955-017-0825-3.