PMID- 29284199
OWN - NLM
STAT- MEDLINE
DCOM- 20180312
LR  - 20220316
IS  - 1349-7006 (Electronic)
IS  - 1347-9032 (Print)
IS  - 1347-9032 (Linking)
VI  - 109
IP  - 3
DP  - 2018 Mar
TI  - Bone marrow mesenchymal stem cells promote head and neck cancer progression 
      through Periostin-mediated phosphoinositide 3-kinase/Akt/mammalian target of 
      rapamycin.
PG  - 688-698
LID - 10.1111/cas.13479 [doi]
AB  - Bone marrow mesenchymal stem cells (BMMSC) have been shown to be recruited to the 
      tumor microenvironment and exert a tumor-promoting effect in a variety of 
      cancers. However, the molecular mechanisms related to the tumor-promoting effect 
      of BMMSC on head and neck cancer (HNC) are not clear. In this study, we 
      investigated Periostin (POSTN) and its roles in the tumor-promoting effect of 
      BMMSC on HNC. In vitro analysis of HNC cells cultured in BMMSC-conditioned media 
      (MSC-CM) showed that MSC-CM significantly promoted cancer progression by 
      enhancing cell proliferation, migration, epithelial-mesenchymal transformation 
      (EMT), and altering expression of cell cycle regulatory proteins and inhibition 
      of apoptosis. Moreover, MSC-CM promoted the expression of POSTN and POSTN 
      promoted HNC progression through the activation of the phosphoinositide 3-kinase 
      (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway. In a murine 
      model of HNC, we found that BMMSC promoted tumor growth, invasion, metastasis and 
      enhanced the expression of POSTN and EMT in tumor tissues. Clinical sample 
      analysis further confirmed that the expression of POSTN and N-cadherin were 
      correlated with pathological grade and lymph node metastasis of HNC. In 
      conclusion, this study indicated that BMMSC promoted proliferation, invasion, 
      survival, tumorigenicity and migration of head and neck cancer through 
      POSTN-mediated PI3K/Akt/mTOR activation.
CI  - (c) 2018 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd 
      on behalf of Japanese Cancer Association.
FAU - Liu, Chuanxia
AU  - Liu C
AD  - Affiliated Hospital of Stomatology, Medical College, Zhejiang University, 
      Hangzhou, China.
FAU - Feng, Xiaoxia
AU  - Feng X
AD  - Affiliated Hospital of Stomatology, Medical College, Zhejiang University, 
      Hangzhou, China.
FAU - Wang, Baixiang
AU  - Wang B
AD  - Affiliated Hospital of Stomatology, Medical College, Zhejiang University, 
      Hangzhou, China.
FAU - Wang, Xinhua
AU  - Wang X
AD  - Affiliated Hospital of Stomatology, Medical College, Zhejiang University, 
      Hangzhou, China.
FAU - Wang, Chaowei
AU  - Wang C
AD  - Affiliated Hospital of Stomatology, Medical College, Zhejiang University, 
      Hangzhou, China.
FAU - Yu, Mengfei
AU  - Yu M
AD  - Affiliated Hospital of Stomatology, Medical College, Zhejiang University, 
      Hangzhou, China.
FAU - Cao, Guifen
AU  - Cao G
AD  - Affiliated Hospital of Stomatology, Medical College, Zhejiang University, 
      Hangzhou, China.
FAU - Wang, Huiming
AU  - Wang H
AUID- ORCID: 0000-0001-5077-7481
AD  - Affiliated Hospital of Stomatology, Medical College, Zhejiang University, 
      Hangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20180123
PL  - England
TA  - Cancer Sci
JT  - Cancer science
JID - 101168776
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Culture Media, Conditioned)
RN  - 0 (POSTN protein, human)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Cell Adhesion Molecules
MH  - Cell Line, Tumor
MH  - Cell Proliferation
MH  - Culture Media, Conditioned/pharmacology
MH  - Disease Progression
MH  - Epithelial-Mesenchymal Transition
MH  - Gene Expression Regulation, Neoplastic
MH  - Head and Neck Neoplasms/*metabolism
MH  - Humans
MH  - Mesenchymal Stem Cells/*cytology/metabolism
MH  - Mice
MH  - Neoplasm Metastasis
MH  - Neoplasm Staging
MH  - Neoplasm Transplantation
MH  - Phosphatidylinositol 3-Kinases/*metabolism
MH  - Proto-Oncogene Proteins c-akt/*metabolism
MH  - Signal Transduction
MH  - TOR Serine-Threonine Kinases/*metabolism
MH  - Up-Regulation
PMC - PMC5834805
OTO - NOTNLM
OT  - PI3K/Akt/mTOR
OT  - Periostin
OT  - bone marrow mesenchymal stem cells
OT  - epithelial mesenchymal transition
OT  - head and neck cancer
EDAT- 2017/12/29 06:00
MHDA- 2018/03/13 06:00
PMCR- 2018/03/01
CRDT- 2017/12/29 06:00
PHST- 2017/06/14 00:00 [received]
PHST- 2017/12/14 00:00 [revised]
PHST- 2017/12/19 00:00 [accepted]
PHST- 2017/12/29 06:00 [pubmed]
PHST- 2018/03/13 06:00 [medline]
PHST- 2017/12/29 06:00 [entrez]
PHST- 2018/03/01 00:00 [pmc-release]
AID - CAS13479 [pii]
AID - 10.1111/cas.13479 [doi]
PST - ppublish
SO  - Cancer Sci. 2018 Mar;109(3):688-698. doi: 10.1111/cas.13479. Epub 2018 Jan 23.