PMID- 29284363
OWN - NLM
STAT- MEDLINE
DCOM- 20190718
LR  - 20220410
IS  - 1568-5624 (Electronic)
IS  - 0920-5063 (Linking)
VI  - 29
IP  - 4
DP  - 2018 Mar
TI  - Preparation, mechanical properties and in vitro cytocompatibility of multi-walled 
      carbon nanotubes/poly(etheretherketone) nanocomposites.
PG  - 428-447
LID - 10.1080/09205063.2017.1422852 [doi]
AB  - Desired bone repair material must have excellent biocompatibility and high 
      bioactivity. Moreover, mechanical properties of biomaterial should be equivalent 
      to those of human bones. For developing an alternative biocomposite for 
      load-bearing orthopedic application, combination of bioactive fillers with 
      polymer matrix is a feasible approach. In this study, a series of multi-walled 
      carbon nanotubes (MWCNTs)/poly(etheretherketone) (PEEK) bioactive nanocomposites 
      were prepared by a novel coprecipitation-compounding and injection-molding 
      process. Scanning electron microscope (SEM) images revealed that MWCNTs were 
      adsorbed on the surface of PEEK particles during the coprecipitation-compounding 
      process and dispersed homogeneously in the nanocomposite because the conjugated 
      PEEK polymers stabilized MWCNTs by forming strong pi-pi stack interactions. The 
      mechanical testing revealed that mechanical performance of PEEK was significantly 
      improved by adding MWCNTs (2-8 wt%) and the experimental values obtained were 
      close to or higher than that of human cortical bone. In addition, incorporation 
      of MWCNTs into PEEK matrix also enhanced the roughness and hydrophilicity of the 
      nanocomposite surface. In vitro cytocompatibility tests demonstrated that the 
      MWCNTs/PEEK nanocomposite was in favor of cell adhesion and proliferation of 
      MC3T3-E1 osteoblast cells, exhibiting excellent cytocompatibility and 
      biocompatibility. Thus, this MWCNTs/PEEK nanocomposite may be used as a promising 
      bone repair material in orthopedic implants application.
FAU - Cao, Jianfei
AU  - Cao J
AD  - a Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences , Chengdu , 
      China.
AD  - b University of Chinese Academy of Sciences , Beijing , China.
FAU - Lu, Yue
AU  - Lu Y
AD  - a Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences , Chengdu , 
      China.
AD  - b University of Chinese Academy of Sciences , Beijing , China.
FAU - Chen, Hechun
AU  - Chen H
AD  - a Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences , Chengdu , 
      China.
FAU - Zhang, Lifang
AU  - Zhang L
AD  - a Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences , Chengdu , 
      China.
FAU - Xiong, Chengdong
AU  - Xiong C
AD  - a Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences , Chengdu , 
      China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180109
PL  - England
TA  - J Biomater Sci Polym Ed
JT  - Journal of biomaterials science. Polymer edition
JID - 9007393
RN  - 0 (Benzophenones)
RN  - 0 (Biocompatible Materials)
RN  - 0 (Ketones)
RN  - 0 (Nanotubes, Carbon)
RN  - 0 (Polymers)
RN  - 31694-16-3 (polyetheretherketone)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
SB  - IM
MH  - Animals
MH  - Benzophenones
MH  - Biocompatible Materials
MH  - Cell Adhesion
MH  - Cell Line
MH  - Cell Proliferation
MH  - Humans
MH  - Ketones/*chemistry
MH  - Materials Testing
MH  - Mice
MH  - Nanocomposites/*chemistry
MH  - Nanotubes, Carbon/*chemistry
MH  - Osteoblasts/cytology
MH  - Polyethylene Glycols/*chemistry
MH  - Polymers
MH  - Prostheses and Implants
MH  - Surface Properties
OTO - NOTNLM
OT  - Carbon nanotubes
OT  - biomaterial
OT  - cell proliferation
OT  - cytocompatibility
OT  - in vitro
OT  - mechanical properties
OT  - poly(etheretherketone)
EDAT- 2017/12/30 06:00
MHDA- 2019/07/19 06:00
CRDT- 2017/12/30 06:00
PHST- 2017/12/30 06:00 [pubmed]
PHST- 2019/07/19 06:00 [medline]
PHST- 2017/12/30 06:00 [entrez]
AID - 10.1080/09205063.2017.1422852 [doi]
PST - ppublish
SO  - J Biomater Sci Polym Ed. 2018 Mar;29(4):428-447. doi: 
      10.1080/09205063.2017.1422852. Epub 2018 Jan 9.