PMID- 29284846
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220311
IS  - 0259-1162 (Print)
IS  - 2229-7685 (Electronic)
IS  - 2229-7685 (Linking)
VI  - 11
IP  - 4
DP  - 2017 Oct-Dec
TI  - Comparison of the Intravenous and Epidural Administration of Tumor Necrosis 
      Factor-alpha Antagonists in an Experimental Rat Pain Model.
PG  - 898-901
LID - 10.4103/aer.AER_160_17 [doi]
AB  - INTRODUCTION: Inflammatory cytokines secreted from the nucleus pulposus are 
      thought to lead to lumbar nerve root compression-like symptoms. Tumor necrosis 
      factor-alpha (TNF-alpha), an inflammatory cytokine, likely plays an important role in 
      lumbar disc hernia-related leg pain. In this experimental study, we compared the 
      effectiveness of TNF-alpha antagonists administered through the intravenous or 
      epidural route in lumbar spine pathologies. MATERIALS AND METHODS: After ethics 
      committee approval had been obtained, 24 Sprague Dawley male rats aged 70-90 days 
      and weighing 250-300 g each were allocated to four groups. In Group I, only the 
      surgical procedure was performed; in Group II, 1 ml of saline solution was 
      administered into the epidural field; in Group III, 10 mg/kg of infliximab was 
      administered into the coccygeal vein; and in Group IV (epidural group), 25 mg of 
      etanercept was administered into the epidural region. RESULTS: When the left leg 
      pull values were analyzed on day 14, whereas there was not a significant 
      difference among the three groups, a decreasing difference was observed in Group 
      IV (P < 0.05). When the 21(st) and 28(th) day left leg pull values were compared 
      between groups, the values from Groups II, III, and IV were significantly lower 
      than those of Group I (P < 0.05). CONCLUSION: The absence of a difference between 
      the baseline values and left leg pull values on days 14, 21, and 28 in Group IV 
      indicates that recovery began on day 21 with the epidural administration of 
      etanercept. There was no difference between intravenous saline administration and 
      intravenous infliximab administration with regard to the start of the recovery. 
      In the present study of rats with discopathy, TNF-alpha antagonists administered 
      epidurally led to earlier recovery from radiculopathy-related allodynia compared 
      to intravenous administration.
FAU - Beyaz, Serbulent Gokhan
AU  - Beyaz SG
AD  - Department of Anesthesiology and Pain Medicine, Sakarya University Faculty of 
      Medicine, Sakarya, Turkey.
FAU - Inanmaz, Mustafa Erkan
AU  - Inanmaz ME
AD  - Department of Orthopedics and Traumatology, Sakarya University Faculty of 
      Medicine, Sakarya, Turkey.
FAU - Ergonenc, Tolga
AU  - Ergonenc T
AD  - Department of Anesthesiology and Reanimation, Sakarya University Training 
      Research, Sakarya, Turkey.
FAU - Palabiyik, Onur
AU  - Palabiyik O
AD  - Department of Anesthesiology and Reanimation, Sakarya University Training 
      Research, Sakarya, Turkey.
FAU - Tomak, Yakup
AU  - Tomak Y
AD  - Department of Anesthesiology and Reanimation, Sakarya University Faculty of 
      Medicine, Sakarya, Turkey.
FAU - Tuna, Ayca Tas
AU  - Tuna AT
AD  - Department of Anesthesiology and Reanimation, Sakarya University Faculty of 
      Medicine, Sakarya, Turkey.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Anesth Essays Res
JT  - Anesthesia, essays and researches
JID - 101578762
PMC - PMC5735485
OTO - NOTNLM
OT  - Cytokine
OT  - discectomy
OT  - epidural
OT  - etanercept
OT  - infliximab
OT  - intravenous
OT  - pain
OT  - tumor necrosis factor-alpha
COIS- There are no conflicts of interest.
EDAT- 2017/12/30 06:00
MHDA- 2017/12/30 06:01
PMCR- 2017/10/01
CRDT- 2017/12/30 06:00
PHST- 2017/12/30 06:00 [entrez]
PHST- 2017/12/30 06:00 [pubmed]
PHST- 2017/12/30 06:01 [medline]
PHST- 2017/10/01 00:00 [pmc-release]
AID - AER-11-898 [pii]
AID - 10.4103/aer.AER_160_17 [doi]
PST - ppublish
SO  - Anesth Essays Res. 2017 Oct-Dec;11(4):898-901. doi: 10.4103/aer.AER_160_17.