PMID- 29285015
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220409
IS  - 1611-2156 (Print)
IS  - 1611-2156 (Electronic)
IS  - 1611-2156 (Linking)
VI  - 16
DP  - 2017
TI  - Evaluation of glutathione S-transferase P1 (GSTP1) Ile105Val polymorphism and 
      susceptibility to type 2 diabetes mellitus, a meta-analysis.
PG  - 1188-1197
LID - 10.17179/excli2017-828 [doi]
AB  - It is well established that type 2 diabetes mellitus (T2DM) is associated with 
      oxidative stress and glutathione S-transferases (GSTs) protect cells against 
      oxidative stress. The missense substitution Ile105Val (rs1695) of the glutathione 
      S-transferase P1 (GSTP1, OMIM: 134660) results from an A/G base substitution at 
      nucleotide 313. Many studies have evaluated the correlation between the rs1695 
      polymorphism and T2DM, but the results remain inconclusive. The aim of the 
      present meta-analysis was to investigate the association between GSTP1 Ile105Val 
      polymorphism and the susceptibility risk of T2DM. Eligible studies (published 
      before August 2017) were identified in several databases. The heterogeneity 
      between studies was evaluated with the chi-square based Q test and the I2 test. 
      The strengths of the association were assessed by pooled odds ratios (ORs) and 
      the corresponding 95 % confidence interval (95 % CI) using either a fixed or 
      random-effects models. Eighteen studies documenting a total of 2595 T2DM cases 
      and 2888 controls were included in this meta-analysis. In the overall analysis 
      there was no significant association between the rs1695 polymorphism and the risk 
      of T2DM. The subgroup analyses stratified by ethnicity, publication year and 
      sample size did not reveal significant association between the study polymorphism 
      and the risk of T2DM and any sources contributing to the substantial 
      heterogeneity between studies. The present meta-analysis suggested that there was 
      significant heterogeneity between studies. Considering some limi tations of our 
      meta-analysis, further large-scale studies should be done to reach a more 
      comprehensive understanding.
FAU - Saadat, Mostafa
AU  - Saadat M
AD  - Department of Biology, College of Sciences, Shiraz University, Shiraz 
      71467-13565, Iran.
LA  - eng
PT  - Journal Article
DEP - 20171106
PL  - Germany
TA  - EXCLI J
JT  - EXCLI journal
JID - 101299402
PMC - PMC5735339
OTO - NOTNLM
OT  - Diabetes mellitus
OT  - genetic polymorphism
OT  - heterogeneity
OT  - risk
OT  - susceptibility
EDAT- 2017/12/30 06:00
MHDA- 2017/12/30 06:01
PMCR- 2017/11/06
CRDT- 2017/12/30 06:00
PHST- 2017/09/20 00:00 [received]
PHST- 2017/10/17 00:00 [accepted]
PHST- 2017/12/30 06:00 [entrez]
PHST- 2017/12/30 06:00 [pubmed]
PHST- 2017/12/30 06:01 [medline]
PHST- 2017/11/06 00:00 [pmc-release]
AID - 2017-828 [pii]
AID - Doc1188 [pii]
AID - 10.17179/excli2017-828 [doi]
PST - epublish
SO  - EXCLI J. 2017 Nov 6;16:1188-1197. doi: 10.17179/excli2017-828. eCollection 2017.