PMID- 29285191
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 15
IP  - 1
DP  - 2018 Jan
TI  - CDKN1A-interacting zinc finger protein 1 is a novel biomarker for lung squamous 
      cell carcinoma.
PG  - 183-188
LID - 10.3892/ol.2017.7282 [doi]
AB  - CDKN1A-interacting zinc finger protein 1 (CIZ1), a nuclear protein that 
      participates in DNA replication, is involved in the pathogenesis of several types 
      of cancer. However, the role of CIZ1 in lung squamous cell carcinoma (LSCC) is 
      not fully understood. In the present study, the expression of CIZ1 in tissue 
      microarrays and surgical samples of human LSCCs was examined. CIZ1 expression was 
      found to be significantly increased in LSCC tissues compared with adjacent 
      tissues or normal controls, whereas expression of a CIZ1-interacting protein, 
      p21(Cip1/Waf1), was decreased. CIZ1 staining intensity and CIZ1-positive vascular 
      invasion were positively correlated with at least two categories of the 
      Tumor-Node-Metastasis (TNM) staging system (T stage, N stage or TNM stage). It 
      was also observed that CIZ1 was specifically expressed in the vascular cells of 
      LSCC tissues. These results indicate that overexpression of CIZ1 may contribute 
      to the growth and angiogenesis of LSCC, thus CIZ1 could represent a biomarker for 
      diagnosis and a target for therapeutic intervention.
FAU - Zhou, Xiaojun
AU  - Zhou X
AD  - Department of Endocrinology, Shandong Provincial Qianfoshan Hospital, Shandong 
      University, Jinan, Shandong 250014, P.R. China.
FAU - Liu, Qiang
AU  - Liu Q
AD  - Laboratory of Microvascular Medicine, Medical Research Center, Shandong 
      Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. 
      China.
FAU - Wada, Youichiro
AU  - Wada Y
AD  - The Research Center for Advanced Science and Technology, The University of Tokyo, 
      Tokyo 153-8904, Japan.
AD  - Isotope Science Center, The University of Tokyo, Tokyo 153-8904, Japan.
FAU - Liao, Lin
AU  - Liao L
AD  - Department of Endocrinology, Shandong Provincial Qianfoshan Hospital, Shandong 
      University, Jinan, Shandong 250014, P.R. China.
FAU - Liu, Ju
AU  - Liu J
AD  - Laboratory of Microvascular Medicine, Medical Research Center, Shandong 
      Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. 
      China.
LA  - eng
PT  - Journal Article
DEP - 20171026
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC5738676
OTO - NOTNLM
OT  - CDKN1A-interacting zinc finger protein 1
OT  - angiogenesis
OT  - lung squamous cell carcinoma
OT  - p21Cip1/Waf1
EDAT- 2017/12/30 06:00
MHDA- 2017/12/30 06:01
PMCR- 2017/10/26
CRDT- 2017/12/30 06:00
PHST- 2016/05/30 00:00 [received]
PHST- 2017/09/22 00:00 [accepted]
PHST- 2017/12/30 06:00 [entrez]
PHST- 2017/12/30 06:00 [pubmed]
PHST- 2017/12/30 06:01 [medline]
PHST- 2017/10/26 00:00 [pmc-release]
AID - OL-0-0-7282 [pii]
AID - 10.3892/ol.2017.7282 [doi]
PST - ppublish
SO  - Oncol Lett. 2018 Jan;15(1):183-188. doi: 10.3892/ol.2017.7282. Epub 2017 Oct 26.