PMID- 29285450
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 2230-8210 (Print)
IS  - 2230-9500 (Electronic)
IS  - 2230-9500 (Linking)
VI  - 21
IP  - 6
DP  - 2017 Nov-Dec
TI  - Neutrophil-lymphocyte Ratio is a Novel Reliable Predictor of Nephropathy, 
      Retinopathy, and Coronary Artery Disease in Indians with Type-2 Diabetes.
PG  - 864-870
LID - 10.4103/ijem.IJEM_197_17 [doi]
AB  - BACKGROUND AND AIMS: Neutrophil-lymphocyte ratio (NLR) has been suggested to be a 
      predictor of coronary artery disease (CAD), and end-organ damage in type-2 
      diabetes mellitus (T2DM). Similar data are lacking from Indians with T2DM. Hence, 
      this study aimed to evaluate the role of NLR as a predictor of microvascular 
      complications and CAD in T2DM. SUBJECTS AND METHODS: Consecutive T2DM patients 
      attending the outpatient services of 2 different hospitals, who gave consent, 
      underwent clinical, anthropometric evaluation, and evaluation for the occurrence 
      of retinopathy, nephropathy, neuropathy, and CAD. RESULTS: A total of 298 
      patients were screened of which 265 patients' data were analyzed. Occurrence of 
      hypertension, neuropathy, nephropathy, retinopathy, and CAD was 12.8%, 18.5%, 
      41.5%, 62.3%, and 3.8%, respectively. Patients in higher NLR quartiles had 
      significantly higher diabetes duration, occurrence of nephropathy, albuminuria, 
      retinopathy, CAD and lpwer glomerular filtration rate. Patients with more 
      microvascular complications had significantly longer diabetes duration, blood 
      pressure, NLR, creatinine, and urine albumin excretion. Binary logistic 
      regression revealed NLR followed by body mass index were best predictors of 
      microvascular complications. NLR had areas under the receiver operating 
      characteristic curve (AUC) of 0.888 (95% CI: 0.848-0.929; P < 0.001), 0.708 (95% 
      CI: 0.646-0.771; P < 0.001), and 0.768 (95% CI: 0.599-938; P = 0.004) in 
      predicting albuminuria, retinopathy, and CAD, respectively. NLR of 2.00 had 
      sensitivity and specificity of 86.4% and 69% in predicting albuminuria; 
      sensitivity and specificity of 64.2% and 63% in predicting retinopathy; 
      sensitivity and specificity of 80% and 47.1% in predicting CAD. CONCLUSION: NLR 
      is inexpensive, easy to use, reliable predictor of nephropathy, retinopathy, and 
      CAD in Indian T2DM.
FAU - Chittawar, Sachin
AU  - Chittawar S
AD  - Department of Medicine, Gandhi Medical College, Bhopal, Madhya Pradesh, India.
FAU - Dutta, Deep
AU  - Dutta D
AD  - Department of Endocrinology, Diabetology and Metabolic Disorders, Venkateshwar 
      Hospitals, Dwarka, New Delhi, India.
FAU - Qureshi, Zahran
AU  - Qureshi Z
AD  - Department of Pharmacology, Gandhi Medical College, Bhopal, Madhya Pradesh, 
      India.
FAU - Surana, Vineet
AU  - Surana V
AD  - Department of Endocrinology, Yashoda Hospital, Hyderabad, Telangana, India.
FAU - Khandare, Sagar
AU  - Khandare S
AD  - Department of Medicine, Gandhi Medical College, Bhopal, Madhya Pradesh, India.
FAU - Dubey, Tribhuvan Nath
AU  - Dubey TN
AD  - Department of Medicine, Gandhi Medical College, Bhopal, Madhya Pradesh, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Endocrinol Metab
JT  - Indian journal of endocrinology and metabolism
JID - 101555690
PMC - PMC5729675
OTO - NOTNLM
OT  - Diabetic nephropathy
OT  - diabetic neuropathy
OT  - diabetic retinopathy
OT  - microvascular complications
OT  - microvascular inflammation
OT  - neutrophil-lymphocyte ratio
OT  - type-2 diabetes
COIS- There are no conflicts of interest.
EDAT- 2017/12/30 06:00
MHDA- 2017/12/30 06:01
PMCR- 2017/11/01
CRDT- 2017/12/30 06:00
PHST- 2017/12/30 06:00 [entrez]
PHST- 2017/12/30 06:00 [pubmed]
PHST- 2017/12/30 06:01 [medline]
PHST- 2017/11/01 00:00 [pmc-release]
AID - IJEM-21-864 [pii]
AID - 10.4103/ijem.IJEM_197_17 [doi]
PST - ppublish
SO  - Indian J Endocrinol Metab. 2017 Nov-Dec;21(6):864-870. doi: 
      10.4103/ijem.IJEM_197_17.