PMID- 29285833
OWN - NLM
STAT- MEDLINE
DCOM- 20180312
LR  - 20210109
IS  - 1349-7006 (Electronic)
IS  - 1347-9032 (Print)
IS  - 1347-9032 (Linking)
VI  - 109
IP  - 3
DP  - 2018 Mar
TI  - Regulatory mechanisms of hypoxia-inducible factor 1 activity: Two decades of 
      knowledge.
PG  - 560-571
LID - 10.1111/cas.13483 [doi]
AB  - Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator of various 
      genes related to cellular adaptive responses to hypoxia. Dysfunctions in the 
      regulatory systems of HIF-1 activity have been implicated in the pathogenesis of 
      various diseases including malignant tumors and, thus, elucidating the molecular 
      mechanisms underlying the activation of HIF-1 is eagerly desired for the 
      development of novel anti-cancer strategies. The importance of oxygen-dependent 
      and ubiquitin-mediated proteolysis of the regulatory subunit of HIF-1 (HIF-1alpha) 
      was first reported in 1997. Since then, accumulating evidence has shown that 
      HIF-1alpha may become stable and active even under normoxic conditions; for example, 
      when disease-associated genetic and functional alterations in some genes trigger 
      the aberrant activation of HIF-1 regardless of oxygen conditions. We herein 
      review the last two decades of knowledge, since 1997, on the regulatory 
      mechanisms of HIF-1 activity from conventional oxygen- and proteolysis-dependent 
      mechanisms to up-to-the-minute information on cancer-associated genetic and 
      functional alteration-mediated mechanisms.
CI  - (c) 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd 
      on behalf of Japanese Cancer Association.
FAU - Koyasu, Sho
AU  - Koyasu S
AD  - Laboratory of Cancer Cell Biology, Department of Genome Dynamics, Radiation 
      Biology Center, Kyoto University, Kyoto, Japan.
AD  - Research Center for Advanced Science and Technology, The University of Tokyo, 
      Tokyo, Japan.
FAU - Kobayashi, Minoru
AU  - Kobayashi M
AD  - Laboratory of Cancer Cell Biology, Department of Genome Dynamics, Radiation 
      Biology Center, Kyoto University, Kyoto, Japan.
FAU - Goto, Yoko
AU  - Goto Y
AD  - Department of Radiation Oncology and Image-applied Therapy, Kyoto University 
      Graduate School of Medicine, Kyoto, Japan.
FAU - Hiraoka, Masahiro
AU  - Hiraoka M
AD  - Department of Radiation Oncology and Image-applied Therapy, Kyoto University 
      Graduate School of Medicine, Kyoto, Japan.
FAU - Harada, Hiroshi
AU  - Harada H
AUID- ORCID: 0000-0001-7507-3173
AD  - Laboratory of Cancer Cell Biology, Department of Genome Dynamics, Radiation 
      Biology Center, Kyoto University, Kyoto, Japan.
AD  - Precursory Research for Embryonic Science and Technology, Japan Science and 
      Technology Agency (JST), Saitama, Japan.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180127
PL  - England
TA  - Cancer Sci
JT  - Cancer science
JID - 101168776
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - EC 1.13.11.- (Dioxygenases)
SB  - IM
MH  - Cell Hypoxia
MH  - Dioxygenases/metabolism
MH  - Gene Expression Regulation, Neoplastic
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Hypoxia-Inducible Factor 1/*genetics/*metabolism
MH  - Neoplasms/*genetics/metabolism
MH  - Ubiquitination
PMC - PMC5834787
OTO - NOTNLM
OT  - gene expression
OT  - hypoxia-inducible factor 1 (HIF-1)
OT  - molecular mechanism
OT  - tumor hypoxia
EDAT- 2017/12/30 06:00
MHDA- 2018/03/13 06:00
PMCR- 2018/03/01
CRDT- 2017/12/30 06:00
PHST- 2017/08/17 00:00 [received]
PHST- 2017/12/09 00:00 [revised]
PHST- 2017/12/24 00:00 [accepted]
PHST- 2017/12/30 06:00 [pubmed]
PHST- 2018/03/13 06:00 [medline]
PHST- 2017/12/30 06:00 [entrez]
PHST- 2018/03/01 00:00 [pmc-release]
AID - CAS13483 [pii]
AID - 10.1111/cas.13483 [doi]
PST - ppublish
SO  - Cancer Sci. 2018 Mar;109(3):560-571. doi: 10.1111/cas.13483. Epub 2018 Jan 27.