PMID- 29286001
OWN - NLM
STAT- MEDLINE
DCOM- 20180731
LR  - 20181202
IS  - 2050-084X (Electronic)
IS  - 2050-084X (Linking)
VI  - 6
DP  - 2017 Dec 29
TI  - Environmental stimuli shape microglial plasticity in glioma.
LID - 10.7554/eLife.33415 [doi]
LID - e33415
AB  - In glioma, microglia and infiltrating macrophages are exposed to factors that 
      force them to produce cytokines and chemokines, which contribute to tumor growth 
      and to maintaining a pro-tumorigenic, immunosuppressed microenvironment. We 
      demonstrate that housing glioma-bearing mice in enriched environment (EE) reverts 
      the immunosuppressive phenotype of infiltrating myeloid cells, by modulating 
      inflammatory gene expression. Under these conditions, the branching and 
      patrolling activity of myeloid cells is increased, and their phagocytic activity 
      is promoted. Modulation of gene expression depends on interferon-(IFN)-gamma produced 
      by natural killer (NK) cells. This modulation disappears in mice depleted of NK 
      cells or lacking IFN-gamma, and was mimicked by exogenous interleukin-15 (IL-15). 
      Further, we describe a key role for brain-derived neurotrophic factor (BDNF) that 
      is produced in the brain of mice housed in EE, in mediating the expression of 
      IL-15 in CD11b(+) cells. These data define novel mechanisms linking environmental 
      cues to the acquisition of a pro-inflammatory, anti-tumor microenvironment in 
      mouse brain.
CI  - (c) 2017, Garofalo et al.
FAU - Garofalo, Stefano
AU  - Garofalo S
AD  - IRCCS Neuromed, Pozzilli, Italy.
FAU - Porzia, Alessandra
AU  - Porzia A
AD  - IRCCS Neuromed, Pozzilli, Italy.
FAU - Mainiero, Fabrizio
AU  - Mainiero F
AD  - Department of Experimental Medicine, Sapienza University, Rome, Italy.
FAU - Di Angelantonio, Silvia
AU  - Di Angelantonio S
AUID- ORCID: 0000-0003-1434-3648
AD  - Department of Physiology and Pharmacology, Sapienza University, Rome, Italy.
AD  - Center for Life Nanoscience, Istituto Italiano di Tecnologia, Rome, Italy.
FAU - Cortese, Barbara
AU  - Cortese B
AD  - Consiglio Nazionale delle Ricerche, Institute of Nanotechnology, Rome, Italy.
FAU - Basilico, Bernadette
AU  - Basilico B
AD  - Department of Physiology and Pharmacology, Sapienza University, Rome, Italy.
FAU - Pagani, Francesca
AU  - Pagani F
AD  - Center for Life Nanoscience, Istituto Italiano di Tecnologia, Rome, Italy.
FAU - Cignitti, Giorgio
AU  - Cignitti G
AD  - Department of Physiology and Pharmacology, Sapienza University, Rome, Italy.
FAU - Chece, Giuseppina
AU  - Chece G
AD  - Department of Physiology and Pharmacology, Sapienza University, Rome, Italy.
FAU - Maggio, Roberta
AU  - Maggio R
AD  - Department of Experimental Medicine, Sapienza University, Rome, Italy.
FAU - Tremblay, Marie-Eve
AU  - Tremblay ME
AD  - Departement de medecine moleculaire, Universite Laval, Quebec, Canada.
FAU - Savage, Julie
AU  - Savage J
AD  - Departement de medecine moleculaire, Universite Laval, Quebec, Canada.
FAU - Bisht, Kanchan
AU  - Bisht K
AD  - Departement de medecine moleculaire, Universite Laval, Quebec, Canada.
FAU - Esposito, Vincenzo
AU  - Esposito V
AD  - IRCCS Neuromed, Pozzilli, Italy.
AD  - Department of Neurology and Psychiatry, Sapienza University, Rome, Italy.
FAU - Bernardini, Giovanni
AU  - Bernardini G
AD  - IRCCS Neuromed, Pozzilli, Italy.
AD  - Department of Molecular Medicine, Sapienza University, Rome, Italy.
FAU - Seyfried, Thomas
AU  - Seyfried T
AD  - Biology Department, Boston College, boston, United States.
FAU - Mieczkowski, Jakub
AU  - Mieczkowski J
AD  - Neurobiology Center, Nencki Institute of Experimental Biology of the Polish 
      Academy of Sciences, Warsaw, Poland.
FAU - Stepniak, Karolina
AU  - Stepniak K
AD  - Neurobiology Center, Nencki Institute of Experimental Biology of the Polish 
      Academy of Sciences, Warsaw, Poland.
FAU - Kaminska, Bozena
AU  - Kaminska B
AD  - Neurobiology Center, Nencki Institute of Experimental Biology of the Polish 
      Academy of Sciences, Warsaw, Poland.
FAU - Santoni, Angela
AU  - Santoni A
AD  - IRCCS Neuromed, Pozzilli, Italy.
AD  - Department of Molecular Medicine, Sapienza University, Rome, Italy.
FAU - Limatola, Cristina
AU  - Limatola C
AUID- ORCID: 0000-0001-7504-8197
AD  - IRCCS Neuromed, Pozzilli, Italy.
AD  - Department of Physiology and Pharmacology, Sapienza University, Laboratory 
      affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Rome, Italy.
LA  - eng
GR  - AIRC2015 IG16699/Associazione Italiana per la Ricerca sul Cancro/International
GR  - PRIN 2015/Ministero dell'Istruzione, dell'Universita e della 
      Ricerca/International
GR  - Starting Grant/CRCHU/International
GR  - Euronanomed2: Nanoglio/European Commission/International
GR  - AIRC2014 IG16014/Associazione Italiana per la Ricerca sul Cancro/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171229
PL  - England
TA  - Elife
JT  - eLife
JID - 101579614
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - *Cell Plasticity
MH  - Cytokines/metabolism
MH  - Disease Models, Animal
MH  - Glioma/*physiopathology
MH  - Immune Tolerance
MH  - Killer Cells, Natural/physiology
MH  - Macrophages/physiology
MH  - Mice
MH  - Microglia/*physiology
MH  - *Tumor Microenvironment
PMC - PMC5774898
OTO - NOTNLM
OT  - Glioma
OT  - NK cells
OT  - enriched environment
OT  - microglia
OT  - mouse
OT  - mouse model
OT  - neuroscience
COIS- SG, AP, FM, SD, BC, BB, FP, GC, GC, RM, MT, JS, KB, VE, GB, TS, JM, KS, BK, AS, 
      CL No competing interests declared
EDAT- 2017/12/30 06:00
MHDA- 2018/08/01 06:00
PMCR- 2017/12/29
CRDT- 2017/12/30 06:00
PHST- 2017/11/09 00:00 [received]
PHST- 2017/12/28 00:00 [accepted]
PHST- 2017/12/30 06:00 [pubmed]
PHST- 2018/08/01 06:00 [medline]
PHST- 2017/12/30 06:00 [entrez]
PHST- 2017/12/29 00:00 [pmc-release]
AID - 33415 [pii]
AID - 10.7554/eLife.33415 [doi]
PST - epublish
SO  - Elife. 2017 Dec 29;6:e33415. doi: 10.7554/eLife.33415.