PMID- 29287626
OWN - NLM
STAT- MEDLINE
DCOM- 20191108
LR  - 20210109
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Print)
IS  - 0920-9964 (Linking)
VI  - 197
DP  - 2018 Jul
TI  - A comparison of conversion rates, clinical profiles and predictors of outcomes in 
      two independent samples of individuals at clinical high risk for psychosis in 
      China.
PG  - 509-515
LID - S0920-9964(17)30727-2 [pii]
LID - 10.1016/j.schres.2017.11.029 [doi]
AB  - OBJECTIVE: In a previous epidemiological study, we reported on the ascertainment 
      and outcomes of "clinical high risk" (CHR) individuals at the Shanghai Mental 
      Health Center (SMHC, "2011 cohort"). The current study compares demographic and 
      clinical characteristics, including conversion rates, of this sample with a 
      subsequently recruited, independent CHR sample and with published data from 
      western samples. METHOD: A new sample of 100 CHR subjects ("2013 cohort") was 
      selected based on screening and semi-structured interviews. Both studies used the 
      Structured Interview for Prodromal Syndromes (SIPS) for CHR assessment and 
      conducted a naturalistic two-year follow-up. The two cohorts were compared on 
      conversion rates, demographic and clinical characteristics, psychosis risk 
      symptoms, and risk factors for psychotic conversion. RESULTS: Ninety one (91%) of 
      the 2013 cohort subjects completed the clinical two-year follow-up and 25 (27.5% 
      of the 91) converted to a psychotic disorder over the follow-up period. A 
      comparison of conversions to full psychosis between the 2013 and the 2011 cohorts 
      showed no significant difference in time to conversion (Pairwise comparison: 
      chi(2)=0.3, p=0.562). Both cohort studies showed that CHR subjects with more severe 
      clinical symptoms at baseline and decline in functioning were more likely to 
      convert to psychosis. CONCLUSIONS: Conversion rates in this new, independent 
      Chinese sample are similar to those reported in non-Chinese samples and to the 
      2011 cohort. Future research is needed to examine whether the implementation of 
      early intervention for CHR/prodromal symptoms reduces the risk of psychosis and 
      decreases the conversion rate.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Li, Huijun
AU  - Li H
AD  - Florida A&M University, Department of Psychology, Tallahassee, FL 32307, USA. 
      Electronic address: huijun.li@famu.edu.
FAU - Zhang, TianHong
AU  - Zhang T
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 
      Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, PR China.
FAU - Xu, LiHua
AU  - Xu L
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 
      Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, PR China.
FAU - Tang, YingYing
AU  - Tang Y
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 
      Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, PR China.
FAU - Cui, HuiRu
AU  - Cui H
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 
      Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, PR China.
FAU - Wei, YanYan
AU  - Wei Y
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 
      Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, PR China.
FAU - Tang, XiaoChen
AU  - Tang X
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 
      Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, PR China.
FAU - Woodberry, Kristen A
AU  - Woodberry KA
AD  - Harvard Medical School Department of Psychiatry, Beth Israel Deaconess Medical 
      Center, 75 Fenwood Rd, Boston, MA 02115, USA.
FAU - Shapiro, Daniel I
AU  - Shapiro DI
AD  - Emory University, Department of Psychology, USA.
FAU - Li, ChunBo
AU  - Li C
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 
      Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, PR China.
FAU - Seidman, Larry J
AU  - Seidman LJ
AD  - Harvard Medical School Department of Psychiatry, Beth Israel Deaconess Medical 
      Center, 75 Fenwood Rd, Boston, MA 02115, USA.
FAU - Wang, JiJun
AU  - Wang J
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 
      Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, PR China. 
      Electronic address: jijunwang27@163.com.
LA  - eng
GR  - K23 MH102358/MH/NIMH NIH HHS/United States
GR  - R01 MH111448/MH/NIMH NIH HHS/United States
GR  - R21 MH093294/MH/NIMH NIH HHS/United States
GR  - R21 MH113674/MH/NIMH NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20171226
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - China
MH  - *Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Prodromal Symptoms
MH  - Psychotic Disorders/*physiopathology
MH  - Risk
MH  - Young Adult
PMC - PMC6019611
MID - NIHMS931041
OTO - NOTNLM
OT  - Clinical high risk
OT  - Conversion rates
OT  - Prodromal psychosis
COIS- Competing financial interests The authors report no biomedical financial 
      interests or potential conflicts of interest.
EDAT- 2017/12/31 06:00
MHDA- 2019/11/09 06:00
PMCR- 2019/06/26
CRDT- 2017/12/31 06:00
PHST- 2017/04/28 00:00 [received]
PHST- 2017/11/12 00:00 [revised]
PHST- 2017/11/24 00:00 [accepted]
PHST- 2017/12/31 06:00 [pubmed]
PHST- 2019/11/09 06:00 [medline]
PHST- 2017/12/31 06:00 [entrez]
PHST- 2019/06/26 00:00 [pmc-release]
AID - S0920-9964(17)30727-2 [pii]
AID - 10.1016/j.schres.2017.11.029 [doi]
PST - ppublish
SO  - Schizophr Res. 2018 Jul;197:509-515. doi: 10.1016/j.schres.2017.11.029. Epub 2017 
      Dec 26.