PMID- 29287822
OWN - NLM
STAT- MEDLINE
DCOM- 20190115
LR  - 20200109
IS  - 2212-1358 (Electronic)
IS  - 2212-134X (Print)
IS  - 2212-134X (Linking)
VI  - 6
IP  - 1
DP  - 2018 Jan
TI  - SRS-22R Minimum Clinically Important Difference and Substantial Clinical Benefit 
      After Adult Lumbar Scoliosis Surgery.
PG  - 79-83
LID - S2212-134X(16)30241-6 [pii]
LID - 10.1016/j.jspd.2017.05.006 [doi]
AB  - STUDY DESIGN: Longitudinal cohort. OBJECTIVES: To determine if the minimum 
      clinically important difference (MCID) and substantial clinical benefit (SCB) 
      thresholds for the Scoliosis Research Society-22R (SRS22R) domains in patients 
      with degenerative lumbar scoliosis are similar to those in patients with adult 
      spinal deformity (ASD) with fusions extending into the thoracic spine. SUMMARY OF 
      BACKGROUND DATA: The MCID and SCB thresholds for the SRS22R domains in patients 
      with ASD and adolescent idiopathic scoliosis have been reported. METHODS: 
      Patients enrolled in the NIH-sponsored Adult Symptomatic Lumbar Scoliosis (ASLS) 
      trial who underwent surgery and completed the SRS22R preoperative and the SRS30 
      one-year postoperative were identified. One-year postoperative answers to the 
      last eight questions of the SRS30 were used as anchors to determine the MCID and 
      SCB for the Pain, Appearance, and Activity domains, and the Subscore and Total 
      score using receiver operating characteristic (ROC) curve analysis. RESULTS: The 
      sample population consisted of 147 patients. A total of 132 (89%) were females 
      with a mean age of 59.4 years. There was a statistically significant improvement 
      in all SRS22R scores from preoperative to one-year postoperative. There was also 
      a statistically significant difference in domain scores among the different 
      responses to the anchors. According to the ROC analysis, MCID was 1.17 for 
      Appearance, 0.40 for Activity, 0.60 for Pain, 0.53 for Subscore, and 0.77 for 
      Total; and SCB was 1.67 for Appearance, 0.60 for Activity, 0.62 for Subscore, and 
      1.11 for Total score. These are similar to previous reports of MCID and SCB 
      thresholds for ASD patients who underwent fusion to the thoracic spine. 
      CONCLUSION: The MCID and SCB thresholds for the SRS22R domains in patients with 
      adult symptomatic lumbar scoliosis are very similar to the threshold values 
      previously reported for adult deformity patients. LEVEL OF EVIDENCE: Level II.
CI  - Copyright (c) 2017 Scoliosis Research Society. Published by Elsevier Inc. All 
      rights reserved.
FAU - Carreon, Leah Y
AU  - Carreon LY
AD  - Norton Leatherman Spine Center, 210 East Gray Street, Suite 900, Louisville, KY 
      40202, USA. Electronic address: leah.carreon@nortonhealthcare.org.
FAU - Kelly, Michael P
AU  - Kelly MP
AD  - Department of Orthopaedic Surgery, Washington University School of Medicine, 660 
      S Euclid Ave, Campus Box 8233, St. Louis, MO 63110, USA.
FAU - Crawford, Charles H 3rd
AU  - Crawford CH 3rd
AD  - Norton Leatherman Spine Center, 210 East Gray Street, Suite 900, Louisville, KY 
      40202, USA; Department of Orthopaedic Surgery, University of Louisville school of 
      Medicine, 550 S. Jackson St., 1st Floor ACB Louisville, KY 40202, USA.
FAU - Baldus, Christine R
AU  - Baldus CR
AD  - Department of Orthopaedic Surgery, Washington University School of Medicine, 660 
      S Euclid Ave, Campus Box 8233, St. Louis, MO 63110, USA.
FAU - Glassman, Steven D
AU  - Glassman SD
AD  - Norton Leatherman Spine Center, 210 East Gray Street, Suite 900, Louisville, KY 
      40202, USA; Department of Orthopaedic Surgery, University of Louisville school of 
      Medicine, 550 S. Jackson St., 1st Floor ACB Louisville, KY 40202, USA.
FAU - Shaffrey, Christopher I
AU  - Shaffrey CI
AD  - Department of Neurosurgery, University of Virginia, PO Box 800212, 
      Charlottesville, VA 22908, USA.
FAU - Bridwell, Keith H
AU  - Bridwell KH
AD  - Department of Orthopaedic Surgery, Washington University School of Medicine, 660 
      S Euclid Ave, Campus Box 8233, St. Louis, MO 63110, USA.
LA  - eng
GR  - R01 AR055176/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PL  - England
TA  - Spine Deform
JT  - Spine deformity
JID - 101603979
SB  - IM
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Lumbar Vertebrae/*surgery
MH  - Male
MH  - Middle Aged
MH  - *Minimal Clinically Important Difference
MH  - Pain Measurement/methods/*statistics & numerical data
MH  - Postoperative Period
MH  - ROC Curve
MH  - Reference Values
MH  - Scoliosis/*surgery
MH  - Spinal Fusion/methods/*statistics & numerical data
MH  - Suture Anchors
MH  - Treatment Outcome
PMC - PMC5751965
MID - NIHMS881700
OTO - NOTNLM
OT  - Adult lumbar spine deformity
OT  - Minimum clinically important difference
OT  - SRS-22R
EDAT- 2017/12/31 06:00
MHDA- 2019/01/16 06:00
PMCR- 2019/01/01
CRDT- 2017/12/31 06:00
PHST- 2016/12/08 00:00 [received]
PHST- 2017/05/24 00:00 [revised]
PHST- 2017/05/27 00:00 [accepted]
PHST- 2017/12/31 06:00 [entrez]
PHST- 2017/12/31 06:00 [pubmed]
PHST- 2019/01/16 06:00 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - S2212-134X(16)30241-6 [pii]
AID - 10.1016/j.jspd.2017.05.006 [doi]
PST - ppublish
SO  - Spine Deform. 2018 Jan;6(1):79-83. doi: 10.1016/j.jspd.2017.05.006.