PMID- 29288061
OWN - NLM
STAT- MEDLINE
DCOM- 20180815
LR  - 20180815
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1681
DP  - 2018 Feb 15
TI  - The effect of brain-derived neurotrophic factor on radiation-induced neuron 
      architecture impairment is associated with the NFATc4/3 pathway.
PG  - 21-27
LID - S0006-8993(17)30566-8 [pii]
LID - 10.1016/j.brainres.2017.12.032 [doi]
AB  - Irradiation to developing brains results in progressive cognitive dysfunction. 
      Changes in the morphology of mature neurons are thought to be related to 
      impairments of cognitive function. However, little is known about the effects of 
      radiation on neurite outgrowth of immature neurons. Therefore, we sought to 
      evaluate the structural alterations of immature neurons following X-ray 
      irradiation and determine potential strategies to reverse it. Our data revealed 
      damage to the neurite outgrowths of cultured neurons after 2 Gy and 8 Gy 
      irradiation at 1 d and 3 d, respectively. De-phosphorylation of nuclear factor of 
      activated T-cells c4/3 (NFATc4/3) was inhibited post-irradiation. Extraneous 
      brain-derived neurotrophic factor (BDNF) ameliorated impairment of neurite growth 
      and activated the NFATc4/3 signaling pathway. These data indicate that BDNF 
      confers neuroprotective effects against irradiation by modulating the NFATc4/3 
      pathway.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Zhang, Qixian
AU  - Zhang Q
AD  - The Second Affiliated Hospital of Soochow University, San Xiang Road No. 1055, 
      Suzhou, Jiangsu, China; Institute of Radiotherapy & Oncology, Soochow University, 
      Suzhou, Jiangsu, China; Suzhou Key Laboratory for Radiation Oncology, Suzhou, 
      Jiangsu, China.
FAU - Li, Xiaoyang
AU  - Li X
AD  - The Second Affiliated Hospital of Soochow University, San Xiang Road No. 1055, 
      Suzhou, Jiangsu, China; Institute of Radiotherapy & Oncology, Soochow University, 
      Suzhou, Jiangsu, China; Suzhou Key Laboratory for Radiation Oncology, Suzhou, 
      Jiangsu, China.
FAU - He, Ru
AU  - He R
AD  - The Second Affiliated Hospital of Soochow University, San Xiang Road No. 1055, 
      Suzhou, Jiangsu, China; Suzhou Key Laboratory for Radiation Oncology, Suzhou, 
      Jiangsu, China.
FAU - Ma, Quanhong
AU  - Ma Q
AD  - Institute of Neuroscience, Soochow University, Ren Ai Road No. 199, Suzhou, 
      Jiangsu, China.
FAU - Sun, Rui
AU  - Sun R
AD  - The Second Affiliated Hospital of Soochow University, San Xiang Road No. 1055, 
      Suzhou, Jiangsu, China; Institute of Radiotherapy & Oncology, Soochow University, 
      Suzhou, Jiangsu, China; Suzhou Key Laboratory for Radiation Oncology, Suzhou, 
      Jiangsu, China.
FAU - Ji, Shengjun
AU  - Ji S
AD  - Institute of Radiotherapy & Oncology, Soochow University, Suzhou, Jiangsu, China; 
      Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, China.
FAU - Wang, Bei
AU  - Wang B
AD  - The Second Affiliated Hospital of Soochow University, San Xiang Road No. 1055, 
      Suzhou, Jiangsu, China. Electronic address: wb3320@126.com.
FAU - Tian, Ye
AU  - Tian Y
AD  - The Second Affiliated Hospital of Soochow University, San Xiang Road No. 1055, 
      Suzhou, Jiangsu, China; Institute of Radiotherapy & Oncology, Soochow University, 
      Suzhou, Jiangsu, China; Suzhou Key Laboratory for Radiation Oncology, Suzhou, 
      Jiangsu, China. Electronic address: dryetian@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171226
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Calcineurin Inhibitors)
RN  - 0 (NFATC Transcription Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Nfatc4 protein, rat)
RN  - 0 (transcription factor NF-AT c3)
RN  - 83HN0GTJ6D (Cyclosporine)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*administration & dosage
MH  - Calcineurin Inhibitors/administration & dosage
MH  - Cells, Cultured
MH  - Cyclosporine/administration & dosage
MH  - Dendrites/drug effects/radiation effects
MH  - Hippocampus/drug effects/metabolism/radiation effects
MH  - Male
MH  - NFATC Transcription Factors/metabolism/*radiation effects
MH  - Nerve Tissue Proteins/metabolism/*radiation effects
MH  - Neuronal Outgrowth/drug effects/radiation effects
MH  - Neurons/drug effects/metabolism/*radiation effects
MH  - Neuroprotective Agents/*administration & dosage
MH  - Phosphorylation
MH  - Rats, Sprague-Dawley
MH  - Signal Transduction/radiation effects
MH  - X-Rays
OTO - NOTNLM
OT  - BDNF
OT  - Ionizing radiation
OT  - NFATc4/3
OT  - Neurite growth
EDAT- 2017/12/31 06:00
MHDA- 2018/08/16 06:00
CRDT- 2017/12/31 06:00
PHST- 2017/08/04 00:00 [received]
PHST- 2017/12/19 00:00 [revised]
PHST- 2017/12/20 00:00 [accepted]
PHST- 2017/12/31 06:00 [pubmed]
PHST- 2018/08/16 06:00 [medline]
PHST- 2017/12/31 06:00 [entrez]
AID - S0006-8993(17)30566-8 [pii]
AID - 10.1016/j.brainres.2017.12.032 [doi]
PST - ppublish
SO  - Brain Res. 2018 Feb 15;1681:21-27. doi: 10.1016/j.brainres.2017.12.032. Epub 2017 
      Dec 26.